Green Tea and Skin

Natural phenolics in the prevention of UV-induced skin damage. A review

“…These polyphenols have been shown to function as anti-inflammatory or anticarcinogenic agents in various biological systems. Of these substances, EGCG has been shown to be the most effective chemoprotective agent against cutaneous inflammatory or carcinogenic responses 63 .…”

Chemoprevention of Skin Cancer with Dietary Phytochemicals

“…It has been demonstrated to suppress UV-B radiation-induced malignant transformation in skin through the regulation of the activation of AP-1, NF-κB and IKK , phosphorylation and degradation of IκB , activation of PI3K, STAT3, ERK, AKT and ERBB2 receptor, VEGF production, and cell cycle and apoptosis associating molecules . As a potent anti-oxidant, EGCG can scavenge ROS, such as lipid free radicals, superoxide radical, hydroxyl radicals, hydrogen peroxide and singlet oxygen (Katiyar et al, 2000). Moreover, EGCG suppressed UV-B radiation-induced skin tumor initiation and development through inhibiting the AP-1 and NF-κB in SKH-1 hairless mouse skin (Mittal et al, 2003).…”

Signal Transduction Pathways: Targets for Green and Black Tea Polyphenols

“…A number of mechanisms explaining tea's anti-cancer actions have been presented including results suggesting that the gallate structure of theaflavins is important for growth inhibition of tumor cell lines by these compounds . One of the most well known actions of tea-associated polyphenolic compounds is their potent antioxidant activity, which has been suggested to be important in alleviating cancer-associated oxidative stresses Benzie et al, 1999;Brown, 1999;Katiyar et al, 1999;Kondo et al, 1999;Lin et al, 1999;Weisburger, 1999b;Weisburger, 1999a;Chen et al, 2000a;Ichihashi et al, 2000;Johnson and Loo, 2000;Jovanovic and Simic, 2000;Katiyar, Ahmad et al, 2000;Langley-Evans, 2000;Liu et al, 2000;Shi et al, 2000;Trevisanato and Kim, 2000;Ahmad and Mukhtar, 2001;Katiyar et al, 2001a;Katiyar, Bergamo et al, 2001b;Katiyar and Elmets, 2001;Owuor and Kong, 2002;. Results of one recent study in which normal human epidermal keratinocytes (NHEK) were pretreated with EGCG prior to UVB exposure, indicated that EGCG inhibited UVBinduced hydrogen peroxide (H 2 O 2 ) production and H 2 O 2 -mediated phosphorylation of mitogen-activated protein kinase (MAPK) signaling pathways (Katiyar et al, 2001a).…”

“…Tea is one of the most popular beverages consumed in the world and has been demonstrated to have anti-cancer activity in animal models. Several very recent review articles have summarized research findings regarding the anti-carcinogenic effects of tea Fujiki, 1999;Gupta et al, 1999;Mukhtar and Ahmad, 1999;Weisburger 1999b;Katiyar et al, 2000;Kong et al, 2000;Lin and Liang 2000;Trevisanato and Kim, 2000;Wang, 2000;Yang et al, 2000a;Ahmad and Mukhtar, 2001;Dong et al, 2001;Katiyar et al, 2001b;Katiyar and Elmets, 2001;Wiseman et al, 2001;Gupta and Mukhtar, 2002;Guyton and Kensler, 2002;Le Marchand, 2002;Yang et al, 2002).…”