Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair

Katiyar, Suchitra; Elmets, Craig A.; Katiyar, Säntosh K.

doi:10.1016/j.jnutbio.2006.08.004

Cited by 182 publications

(120 citation statements)

References 65 publications

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“…75 ). Epicatechin can reduce the risk of four of the major health problems: stroke, heart failure, cancer and diabetes 76 . Acylated fl avonoids, such as epicatechin are reported to be absorbed without deconjugation and hydrolysis 77 .…”

Section: Flavonols Fl Avons and Fl Avan-3-olsmentioning

confidence: 99%

Berry Fruits as a Source of Biologically Active Compounds: The Case of Lonicera Caerulea

Švarcová

Heinrich²,

Valentová³

2007

BIOMED PAP

102

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Section: Flavonols Fl Avons and Fl Avan-3-olsmentioning

confidence: 99%

Berry Fruits as a Source of Biologically Active Compounds: The Case of Lonicera Caerulea

Švarcová

Heinrich²,

Valentová³

2007

BIOMED PAP

102

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“…Green tea is known to contain high levels of antioxidant components such as catechin (a polyphenolic antioxidant), and has been shown to provide various health benefits, based on extensive studies in humans and animals. [12][13][14] The DPPH antioxidant assay using PVA-based pellets offers a simple and practical method for measuring the antioxidant capacity of natural products.…”

Section: Resultsmentioning

confidence: 99%

An Antioxidant Capacity Assay Using a Polyvinyl Alcohol-Based DPPH Pellet

Ahn¹,

Yoo²,

Kim³

2010

Bulletin of the Korean Chemical Society

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To assay for antioxidant capacity of natural products considered important in producing human health benefits, a practical and economical method using pellet techniques was developed. A standard visualizing reagent, 1,1diphenyl-2-picryl-hydrazyl (DPPH), was mixed with a water-miscible polyvinyl alcohol (PVA), serving as a solid phase support for the DPPH reagent. A DPPH pellet was prepared by dropping a small volume of the DPPH solution onto PET film, and drying in an oven. The PVA-based DPPH pellet was dissolved into water, in which the water-miscible PVA plays as a non-ionic surfactant to help the DPPH reagent to be dissolved into the solvent. Using the DPPH assay, the antioxidant capacity of water-soluble extracts of black soybean, barley, green tea, and green gram was examined. Among the natural products tested, green tea showed the highest antioxidant capacity. This PVA-based DPPH antioxidant assay can be further applied in the natural food, raw plant material, and health product inspection field.

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“…Increased endogenous antioxidants could protect rat hearts from oxidative stress associated with ischemia/reperfusion injury [23]. The EGCG derivative of green tea is a potent antioxidant [24]. EGCG scavenges free radicals induced by isoproterenol in Wistar rats pretreated with EGCG (30 mg/kg body weight) orally for 21 days [25].…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Epigallocatechin-3 Gallate on Ischemia/Reperfusion Injury in Isolated Rat Hearts: Anex vivoApproach

Piao

Kim

et al. 2011

Korean J Physiol Pharmacol

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The aim of this study was to evaluate the preventive role of epigallocatechin-3 gallate (EGCG, a derivative of green tea) in ischemia/reperfusion (I/R) injury of isolated rat hearts. It has been suggested that EGCG has beneficial health effects, including prevention of cancer and heart disease, and it is also a potent antioxidant. Rat hearts were subjected to 20 min of normoxia, 20 min of zero-flow ischemia and then 50 min of reperfusion. EGCG was perfused 10 min before ischemia and during the whole reperfusion period. EGCG significantly increased left ventricular developed pressure (LVDP) and increased maximum positive and negative dP/dt (＋ /-dP/dtmax). EGCG also significantly increased the coronary flow (CF) at baseline before ischemia and at the onset of the reperfusion period. Moreover, EGCG decreased left ventricular end diastolic pressure (LVEDP). This study showed that lipid peroxydation was inhibited and Mn-SOD and catalase expressions were increased in the presence of EGCG. In addition, EGCG increased levels of Bcl-2, Mn-superoxide dismutase (SOD), and catalase expression and decreased levels of Bax and increased the ratio of Bcl-2/Bax in isolated rat hearts. Cleaved caspase-3 was decreased after EGCG treatment. EGCG markedly decreased the infarct size while attenuating the increase in lactate dehydrogenase (LDH) levels in the effluent. In summary, we suggest that EGCG has a protective effect on I/R-associated hemodynamic alteration and injury by acting as an antioxidant and anti-apoptotic agent in one.

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Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair

Cited by 182 publications

References 65 publications

Berry Fruits as a Source of Biologically Active Compounds: The Case of Lonicera Caerulea

Berry Fruits as a Source of Biologically Active Compounds: The Case of Lonicera Caerulea

An Antioxidant Capacity Assay Using a Polyvinyl Alcohol-Based DPPH Pellet

The Protective Effect of Epigallocatechin-3 Gallate on Ischemia/Reperfusion Injury in Isolated Rat Hearts: Anex vivoApproach

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