Green Tea Ameliorates Hyperglycemia by Promoting the Translocation of Glucose Transporter 4 in the Skeletal Muscle of Diabetic Rodents

Abstract

It is known that green tea helps prevent obesity and diabetes mellitus. In this study, we aimed to determine whether green tea ameliorates hyperglycemia and the mechanism involved in diabetic rodents. Green tea consumption reduced blood glucose and ameliorated glucose intolerance, which was assessed using an oral glucose tolerance test in both streptozotocin-induced type 1 diabetic rats and type 2 diabetic KK-Ay mice. Green tea also reduced the plasma fructosamine and glycated hemoglobin concentrations in both models. Furthermore, it increased glucose uptake into the skeletal muscle of both model animals, which was accompanied by greater translocation of glucose transporter 4 (GLUT4). Moreover, epigallocatechin gallate (EGCG), the principal catechin in green tea, also ameliorated glucose intolerance in high-fat diet-induced obese and diabetic mice. These results suggest that green tea can ameliorate hyperglycemia in diabetic rodents by stimulating GLUT4-mediated glucose uptake in skeletal muscle, and that EGCG is one of the effective compounds that mediate this effect.

Phenolic Profile, Antioxidant, and Antidiabetic Potential Exerted by Millet Grain Varieties

“…The catechin content in finger Italian millet (577.49 µg/100g) was found to be four times higher as compared with their corresponding amount in barnyard millet (146.1 µg/100g). This could account for the higher inhibition activities of T2D related digestive enzymes, as catechins have been shown to be effective in controlling hyperglycemia and ameliorating diabetes [45,46]. However, this effect could also be synergistically enhanced by other flavonoids present.…”

Coumaroyl Flavonol Glycosides and More in Marketed Green Teas: An Intrinsic Value beyond Much-Lauded Catechins

“…Cancer prevention with green tea was also recently reviewed; green tea, beyond the ability to delay cancer onset and to reduce its incidence, was reported as a useful strategy in secondary and tertiary cancer prevention [10]. Furthermore, cardiometabolic diseases, such as the ongoing metabolic syndrome, dyslipidemia, and diabetes, are reported to be beneficially alleviated by green tea [11]. These findings appeared to promote the therapeutic implementation of green tea [12].…”

Possible ameliorative role of green tea on chronic alcohol mediated renal toxicity of STZ -induced diabetic rats

“…The consumption of green tea is conscious health benefitable habit, and is the key marker to reduce many of the dangerous impacts with a focus on oxidative and nitrosative stress induced by diabetes [13] as well as by alcohol abuse [14]. EGCG reduced hyperglycaemic condition disturbs all the metabolic pathways directly or indirectly, and also has proven that it ameliorates glucose intolerance [15]. Though green tea is reported to exert effect on ethanol metabolism, its role in amelioration of toxicity and related events and precise mechanisms under diabetic condition is not known.…”