Cross-reactive sensor arrays are useful for discriminating
multiple
analytes in a complex sample. Herein, a portable and label-free gas
pressure sensor array was proposed for multiplex analysis via a handheld
gas pressure meter. It is based on the interaction diversity of analytes
with catalase-like nanomaterials, including Pt nanoparticles (PtNP),
Co3O4 nanosheets (Co3O4NS), and Pt–Co alloy nanosheets (PtCoNS), respectively. Thus,
the diverse influence of analytes on the catalase-like activity could
be output as the difference in the gas pressure. By using principal
component analysis, eight proteins were well distinguished by the
gas pressure sensor array at the 10 nM level within 12 min. Moreover,
different concentrations of proteins and mixtures of proteins could
likewise be discriminated. More importantly, the effective discrimination
of proteins in human serum and discrimination of five kinds of cells
further confirmed the potential of the gas pressure sensor array.
Therefore, it provides a portable, cheap, sensitive, and label-free
gas pressure sensor array, which is totally different from the reported
sensor arrays and holds great potential for portable and cheap discrimination
of multiple analytes.