Green Synthesized Calcium Oxide Nanoparticles (CaO NPs) Using Leaves Aqueous Extract of Moringa oleifera and Evaluation of Their Antibacterial Activities

Jadhav, Vikram R.; Bhagare, Arun M.; Wahab, Shadma; Lokhande, Dnyaneshwar; Vaidya, Chandraprabha; Dhayagude, Akshay; Khalid, Mohammad; Aher, Jayraj S.; Mezni, Amine; Dutta, Mycal

doi:10.1155/2022/9047507

Cited by 29 publications

(9 citation statements)

References 26 publications

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“…The XRD peaks were well matched with Joint Committee for Powder Diffraction Standard (JCPDS) Card No. 00-004-0777, also reported by Jadhav et al [ 9 ].…”

Section: Discussionsupporting

confidence: 57%

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Biosynthesis and Characterization of Calcium Oxide Nanoparticles from Citrullus colocynthis Fruit Extracts; Their Biocompatibility and Bioactivities

et al. 2023

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Modern nanotechnology encompasses every field of life. Nowadays, phytochemically fabricated nanoparticles are being widely studied for their bioactivities and biosafety. The present research studied the synthesis, characterization, stability, biocompatibility, and in vitro bioactivities of calcium oxide nanoparticles (CaONPs). The CaONPs were synthesized using Citrullus colocynthis ethanolic fruit extracts. Greenly synthesized nanoparticles had an average size of 35.93 ± 2.54 nm and showed an absorbance peak at 325 nm. An absorbance peak in this range depicts the coating of phenolic acids, flavones, flavonols, and flavonoids on the surface of CaONPs. The XRD pattern showed sharp peaks that illustrated the preferred cubic crystalline nature of triturate. A great hindrance to the use of nanoparticles in the field of medicine is their extremely reactive nature. The FTIR analysis of the CaONPs showed a coating of phytochemicals on their surface, due to which they showed great stability. The vibrations present at 3639 cm−1 for alcohols or phenols, 2860 cm−1 for alkanes, 2487 cm−1 for alkynes, 1625 cm−1 for amines, and 1434 cm−1 for carboxylic acids and aldehydes show adsorption of phytochemicals on the surface of CaONPs. The CaONPs were highly stable over time; however, their stability was slightly disturbed by varying salinity and pH. The dialysis membrane in vitro release analysis revealed consistent nanoparticle release over a 10-h period. The bioactivities of CaONPs, C. colocynthis fruit extracts, and their synergistic solution were assessed. Synergistic solutions of both CaONPs and C. colocynthis fruit extracts showed great bioactivity and biosafety. The synergistic solution reduced cell viability by only 14.68% and caused only 16% hemolysis. The synergistic solution inhibited Micrococcus luteus slightly more effectively than streptomycin, with an activity index of 1.02. It also caused an 83.87% reduction in free radicals.

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“…The XRD peaks were well matched with Joint Committee for Powder Diffraction Standard (JCPDS) Card No. 00-004-0777, also reported by Jadhav et al [ 9 ].…”

Section: Discussionsupporting

confidence: 57%

“…These metallic nanoparticles have an antioxidant activity of about 79.67% [ 8 ]. Moringa olifera leaf extracts can be used to easily synthesize CaONPs that have powerful antibacterial and antioxidant properties [ 9 ]. Calcium oxide nanoparticles produced from Trigona sp.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and Characterization of Calcium Oxide Nanoparticles from Citrullus colocynthis Fruit Extracts; Their Biocompatibility and Bioactivities

et al. 2023

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“…Meanwhile, the identification of functional groups in the sample is listed in Table . The broad spectrum at 3450 cm –1 shows the absorption of the hydroxyl group . C–H stretching absorption was found at 2940 and 2832 cm –1 .…”

Section: Resultsmentioning

confidence: 99%

Molecular Recognition ofMoringa oleiferaActive Compounds for Stunted Growth Prevention Using Network Pharmacology and Molecular Modeling Approach

Arwansyah,

Lewa,

Muliani

et al. 2023

ACS Omega

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In this study, network pharmacology was used to analyze the active compounds of Moringa oleifera as food supplements for stunted growth prevention. Thirty-eight important proteins were discovered that may be strongly related to stunting. Those proteins were uploaded to several online tool platforms in order to determine the shared genes’ pathways. Six pathways were identified that may be correlated with human growth. Furthermore, ligands for molecular docking analysis were retrieved from the top 5 active substances discovered through experimental investigation. In the meantime, the first-degree rank based on the protein–protein interaction (PPI) topological analysis was utilized to choose albumin protein (ALB) as a receptor. Our docking results showed that every ligand binds to the receptors, indicating that they can bind to the binding site of the ALB protein to form a complex formation. Further, MD simulation was used to verify the stability of the ligand in complex with the protein in the TIP3P water model. Based on the validation parameters, our results suggested that all models achieved a stable phase along the simulation. Additionally, the MM-GBSA method was used to calculate the binding energies of all models. Ligands 2 and 4 have strong binding to the binding pocket of ALB, followed by ligands 3, 5, and 2, suggesting that those ligands could be promising food supplements that can be utilized for the prevention of stunted growth in children.

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“…The average crystalline grain size of the polyol-mediated ZnO NPs is 18.09 nm, measured with the help of the Scherrer equation ( Jadhav et al, 2022b ).…”

Section: Resultsmentioning

confidence: 99%

Polyol-mediated zinc oxide nanoparticles using the refluxing method as an efficient photocatalytic and antimicrobial agent

Walunj¹,

Roy

Jadhav³

et al. 2023

Front. Bioeng. Biotechnol.

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Nanomaterials have attracted more curiosity recently because of their wide-ranging application in environmental remediation and electronic devices. The current study focuses on zinc oxide nanoparticles’ (ZnO NPs) simple production, characterization, and applications in several fields, including medicinal and photocatalytic degradation of dyes. The non-aqueous-based reflux method is helpful for ZnO NP synthesis; the procedure involves refluxing zinc acetate dihydrate precursor in ethylene glycol for 3 hours in the absence of sodium acetate, in which the refluxing rate and the cooling rate are optimized to get the desired phase, and the unique morphology of polyol-mediated ZnO NPs; it has been achieved using the capping agent TBAB (tetra-butyl ammonium bromide) and precursor zinc acetate dihydrate. UV–Vis, FTIR, XRD, and FESEM structurally characterized polyol-mediated ZnO-NPs. The results show that the material is pure and broadly aggregated into spherical nanoparticles with an average particle size of 18.09 nm. According to XRD analysis, heat annealing made the crystallites more prominent and favored a monocrystalline state. These results and the low cost of making polyol-mediated ZnO NPs demonstrate photocatalytic and antimicrobial properties.

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Green Synthesized Calcium Oxide Nanoparticles (CaO NPs) Using Leaves Aqueous Extract of Moringa oleifera and Evaluation of Their Antibacterial Activities

Cited by 29 publications

References 26 publications

Biosynthesis and Characterization of Calcium Oxide Nanoparticles from Citrullus colocynthis Fruit Extracts; Their Biocompatibility and Bioactivities

Biosynthesis and Characterization of Calcium Oxide Nanoparticles from Citrullus colocynthis Fruit Extracts; Their Biocompatibility and Bioactivities

Molecular Recognition ofMoringa oleiferaActive Compounds for Stunted Growth Prevention Using Network Pharmacology and Molecular Modeling Approach

Polyol-mediated zinc oxide nanoparticles using the refluxing method as an efficient photocatalytic and antimicrobial agent

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