Green synthesised zinc oxide nanostructures through Periploca aphylla extract shows tremendous antibacterial potential against multidrug resistant pathogens

Abstract

To grapple with multidrug resistant bacterial infections, implementations of antibacterial nanomedicines have gained prime attention of the researchers across the globe. Nowadays, zinc oxide (ZnO) at nano-scale has emerged as a promising antibacterial therapeutic agent. Keeping this in view, ZnO nanostructures (ZnO-NS) have been synthesised through reduction by aqueous extract without the utilisation of any acid or base. Structural examinations via scanning electron microscopy (SEM) and X-ray diffraction have revealed pure phase morphology with highly homogenised average particle size of 18 nm. SEM findings were further supplemented by transmission electron microscopy examinations. The characteristic Zn-O peak has been observed around 363 nm using ultra-violet-visible spectroscopy. Fourier-transform infrared spectroscopy examination has also confirmed the formation of ZnO-NS through detection of Zn-O bond vibration frequencies. To check the superior antibacterial activity of ZnO-NS, the authors' team has performed disc diffusion assay and colony forming unit testing against multidrug resistant and . Furthermore, protein kinase inhibition assay and cytotoxicity examinations have revealed that green fabricated ZnO-NS are non-hazardous, economical, environmental friendly and possess tremendous potential to treat lethal infections caused by multidrug resistant pathogens.

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

“…This is probably due to the extensive use of hazardous acid base synthetic reagents in NS preparation by these methods ( Dekkers et al, 2017 ). On the other hand, green chemistry proves to be an efficient and most reliable method to engineer highly biocompatible NS ( Abbas et al, 2017b ). Moreover, mild cytotoxicity activities of green-synthesized NS are probably due to high concentration metal ion intoleration, NS sedimentation, loss of NS-homeostasis, genotoxicity, or lethal ROS induction ( Li et al, 2016 ).…”

Green-synthesised cerium oxide nanostructures (CeO2-NS) show excellent biocompatibility for phyto-cultures as compared to silver nanostructures (Ag-NS)

“…This smaller crystallite morphology plays important role in biological applications of NS. 29 Smaller NS means greater surface area with maximum reactivity. SEM micrograph (Fig.…”

Genus Periploca (Apocynaceae): A Review of Its Classification, Phytochemistry, Biological Activities and Toxicology

“…What is striking is that ZnO nanostructures with tremendous potential against multidrug-resistant E. coli , S. marcescens and E. cloacae were synthesized through reduction by P. aphylla aqueous extract without the utilization of any acid or base. In this manner, the aqueous extract of P. aphylla was proven to be a valid chelating agent [181].…”