Green synthesis of zinc oxide nanoparticles using Portulaca oleracea (Regla seeds) extract and its biomedical applications

Abstract

In the present study, the biosynthesis of ZnONPs utilizing Portulaca oleracea seeds aqueous extract has been reported. The reported method is a green, plant-extract mediated and low-cost approach that is capable of synthesizing ZnONPs at pH 7 with heating at 60 o C for one hour. To demonstrate the efficiency of the capping bioorganic molecules on ZnO nanoparticles, a part of the product was dried at 60 o C (denoted ZnO-60) and the other part was annealed at 500 o C (denoted ZnO-500). Both synthesized ZnONPs was crystalline in nature and hexagonal in shape with an average size of 14 nm and 34.5 nm for ZnO-60 and ZnO-500, respectively, as evidenced by XRD and TEM analysis. The synthesized nanoparticles showed high antioxidant, good antibacterial activity, which has inhibited the growth of Helicobacter pylori (ATCC 700392) and Methicillin-Resistant Staphylococcus aureus bacteria and anticancer activity for HCT-116 cells with a higher efficiency of ZnO-60 than ZnO-500

Anticancer and Antioxidant Activity of the Greenly Synthesized Zinc Nanoparticles Composites using Aqueous Extract of Withania Somnifera plant

“…The analysis of phytochemical constitutes was intended to determine the active constitutes of the W. somnifera leaves extract and its synthesized zinc nanoparticles. In this course, the analysis of this type quantitatively estimates the secondary metabolites of both samples, which were consumed in the generation of nanoparticles through a reduction process [65]. The phytochemical profile included the calculation of phenolic, flavonoid, and tannin contents to explore the supplementary factors that will increase the metal nanoparticles formation as these categorized groups act as reducing, and stabilizing agents in this green protocol of the synthesis.…”