Green synthesis of zinc oxide nanoparticles using Cinnamomum camphora (L.) Presl leaf extracts and its antifungal activity

Zhu, Wenjia; Hu, Chunmei; Ren, Yulong; Lu, Ying; Song, Yaping; Ji, Yu; Han, Chuan Hsiao; He, Junyu

doi:10.1016/j.jece.2021.106659

Cited by 47 publications

(28 citation statements)

References 42 publications

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“…In the XRD pattern, the presence of planes (100), (002), (101), (110), ( 112) and (202) affirmed the formation of a pure wurtzite structure in the ZnO NPs [66]. Similar findings were reported by Ifeanyichukwu et al (2020) who reported that biogenic ZnO nanoparticles synthesized using pomegranate flower extract revealed seven diffraction peaks at 2θ values of 36.25 , corresponding to lattice planes of (100), ( 002), ( 101), ( 102), ( 110), ( 103), ( 200), ( 112), ( 201) and (202), respectively [30]. The narrow and sharp peaks of the XRD pattern affirmed the fine crystalline structure of the biosynthesized zinc oxide nanoparticles [67].…”

Section: X-ray Diffraction (Xrd) Analysissupporting

confidence: 81%

“…The narrow and sharp peaks of the XRD pattern affirmed the fine crystalline structure of the biosynthesized zinc oxide nanoparticles [67]. and (202), respectively [30]. The narrow and sharp peaks of the XRD pattern affirmed the fine crystalline structure of the biosynthesized zinc oxide nanoparticles [67].…”

Section: X-ray Diffraction (Xrd) Analysismentioning

confidence: 74%

“…In [25], after the zinc precursor was completely reduced, a reaction occurred between metallic zinc and dissolved oxygen in the solution, resulting in the production of ZnO nanoparticles. Several previous studies reported the remarkable antimycotic and antibacterial activity of green-synthesized ZnO nanoparticles against different microbial pathogens [26][27][28][29][30]. In this context, aqueous stem extract of Rutagraveolen mediated green synthesis of zinc oxide nanoparticles with potential antioxidant and antimicrobial activities [31].…”

Section: Introductionmentioning

confidence: 93%

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Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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The high incidence of fungal resistance to antifungal drugs represents a global concern, contributing to high levels of morbidity and mortality, especially among immunocompromised patients. Moreover, conventional antifungal medications have poor therapeutic outcomes, as well as possible toxicities resulting from long-term administration. Accordingly, the aim of the present study was to investigate the antifungal effectiveness of biogenic zinc oxide nanoparticles (ZnO NPs) against multidrug-resistant candidal strains. Biogenic ZnO NPs were characterized using physicochemical methods, such as UV-vis spectroscopy, transmission electron microscopy (TEM), energy-dispersive X ray (EDX) spectroscopy, FTIR (Fourier transform infrared) spectroscopy and X-ray powder diffraction (XRD) analysis. UV spectral analysis revealed the formation of two absorption peaks at 367 and 506 nm, which preliminarily indicated the successful synthesis of ZnO NPs, whereas TEM analysis showed that ZnO NPs exhibited an average particle size of 22.84 nm. The EDX spectrum confirmed the successful synthesis of ZnO nanoparticles free of impurities. The FTIR spectrum of the biosynthesized ZnO NPs showed different absorption peaks at 3427.99, 1707.86, 1621.50, 1424.16, 1325.22, 1224.67, 1178.22, 1067.69, 861.22, 752.97 and 574.11 cm−1, corresponding to various functional groups. The average zeta potential value of the ZnO NPs was −7.45 mV. XRD analysis revealed the presence of six diffraction peaks at 2θ = 31.94, 34.66, 36.42, 56.42, 69.54 and 76.94°. The biogenic ZnO NPs (100µg/disk) exhibited potent antifungal activity against C. albicans, C. glabrata and C. tropicalis strains, with suppressive zone diameters of 24.18 ± 0.32, 20.17 ± 0.56 and 26.35 ± 0.16 mm, respectively. The minimal inhibitory concentration (MIC) of ZnO NPs against C. tropicalis strain was found to be 10 μg/mL, whereas the minimal fungicidal concentration (MFC) was found to be 20 μg/mL. Moreover, ZnO NPs revealed a potential synergistic efficiency with fluconazole, nystatin and clotrimazole antifungal drugs against C. albicans strain, whereas terbinafine, nystatin and itraconazole antifungal drugs showed a potential synergism with ZnO NPs against C. glabrata as a multidrug-resistant strain. In conclusion, pomegranate peel extract mediated green synthesis of ZnO NPs with potential physicochemical features and antimicrobial activity. The biosynthesized ZnO NPs could be utilized for formulation of novel drug combinations to boost the antifungal efficiency of commonly used antifungal agents.

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Section: X-ray Diffraction (Xrd) Analysissupporting

confidence: 81%

Section: X-ray Diffraction (Xrd) Analysismentioning

confidence: 74%

Section: Introductionmentioning

confidence: 93%

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Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

et al. 2022

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“… 65 Excessive MDA will change the structure and function of biological macromolecules on the cell membrane, such as lipids, proteins, and nucleic acids, resulting in cell metabolic disorders and even death. 66 Therefore, we inferred that the petroleum ether extract of M. cortex inhibited the activity of R. solani by inducing excessive accumulation of the MDA content, resulting in increased membrane permeability, which may be one of the antifungal mechanisms of the petroleum ether extract of M. cortex . This is consistent with the antifungal mechanism of the Eriobotrya japonica leaf extract and the Chinese herbal extract compound (CHEC) on MDA.…”

Section: Discussionmentioning

confidence: 93%

“…MDA is a key indicator of cell membrane lipid peroxidation . Excessive MDA will change the structure and function of biological macromolecules on the cell membrane, such as lipids, proteins, and nucleic acids, resulting in cell metabolic disorders and even death . Therefore, we inferred that the petroleum ether extract of M.…”

Section: Discussionmentioning

confidence: 99%

Anti-Fungal Activity of Moutan cortex Extracts against Rice Sheath Blight (Rhizoctonia solani) and Its Action on the Pathogen’s Cell Membrane

Zhao

Wang

et al. 2022

ACS Omega

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Rice sheath blight (RSB) caused by Rhizoctonia solani is one of the most destructive diseases of rice (Oryza sativa). Although chemical fungicides are the most important control methods, their long-term unreasonable application has brought about problems such as environmental pollution, food risks, and non-target poisoning. Therefore, considering the extraction of fungistatic substances from plants may be an alternative in the future. In this study, we found that the Moutan cortex ethanol extract has excellent antifungal activity against R. solani, with a 100% inhibition rate at 1000 μg/mL, which aroused our great exploration interest. In-depth exploration found that the antifungal active ingredients of M. cortex were mainly concentrated in the petroleum ether extract of the M. cortex ethanol extract, which still maintained a 100% inhibition rate with 250 μg/mL, and its effective medium concentration (EC 50 ) was 145.33 μg/mL against R. solani. Through the measurement of extracellular relative conductivity and OD 260 , the petroleum ether extract induced leakage of intracellular electrolytes and nucleic acids, indicating that the cell membrane was ruined. Therefore, we preliminarily determined that the cell membrane may be the target of the petroleum ether extract. Moreover, we found that petroleum ether extract reduced the content of ergosterol, a component of the cell membrane, which may be one of the reasons for the cell membrane destruction. Furthermore, the increase of MDA content would lead to membrane lipid peroxidation, further aggravating membrane damage, resulting in increased membrane permeability. Also, the destruction of the cell membrane was observed by the phenomenon of the mycelium being transparent and broken. In conclusion, this is the first report of the M. cortex petroleum ether extract exhibiting excellent antifungal activity against R. solani. The effect of the M. cortex petroleum ether extract on R. solani may be on the cell membrane, inducing the disorder of intracellular substances and metabolism, which may be one of the antifungal mechanisms against R. solani.

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Nanomedicinal Approaches to Treat Fungal Livestock Diseases

Ghosh,

Chowdhury

2024

Nanotechnology Theranostics in Livestock Diseases and Management

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Green synthesis of zinc oxide nanoparticles using Cinnamomum camphora (L.) Presl leaf extracts and its antifungal activity

Cited by 47 publications

References 42 publications

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Facile Green Synthesis of Zinc Oxide Nanoparticles with Potential Synergistic Activity with Common Antifungal Agents against Multidrug-Resistant Candidal Strains

Anti-Fungal Activity of Moutan cortex Extracts against Rice Sheath Blight (Rhizoctonia solani) and Its Action on the Pathogen’s Cell Membrane

Nanomedicinal Approaches to Treat Fungal Livestock Diseases

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