Green synthesis of silver nanoparticles using Phlebopus portentosus polysaccharide and their antioxidant, antidiabetic, anticancer, and antimicrobial activities

Li, Hong-Fu; Pan, Zhang-Chao; Chen, Jiao-Man; Zeng, Lei-Xia; Xie, Hui-Jing; Liang, Zhi-Qun; Wang, Yong; Zeng, Nian-Kai

doi:10.1016/j.ijbiomac.2023.127579

Cited by 3 publications

(1 citation statement)

References 69 publications

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“…For example, Khwanta Kaewnarin et al extracted bioactive polysaccharides from P. portentosus using conventional refluxing extraction (RFE) and ultrasound-assisted extraction (UAE), revealing glucose as the prevalent monosaccharide with both αand β-glycosidic conformations present [11]. In a recent study, P. portentosus polysaccharides (PPPs) were obtained through water-ethanol precipitation and the Sevaga method, unveiling a molecular weight distribution (Mn, Mw, Mp) and a composition of ten monosaccharides [12]. Furthermore, purified Boletus polysaccharides confirmed α-glycosidic bonds through nuclear magnetic resonance (NMR) [13].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Immunological Activity of Polysaccharide Degradation Products from Phlebopus portentosus

Yu,

Cai,

Wang

et al. 2024

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Phlebopus portentosus is an edible and medicinal mushroom with a delicious taste and high nutritional value. The oligosaccharides derived from P. portentosus may be the material basis for its biological activity. The degradation of polysaccharide and the maintenance of its activity after degradation are key steps in related research. This study applied an acid degradation method to prepare P. portentosus refined polysaccharide (PPRP) with a smaller molecular weight, and the optimal hydrolysis conditions determined were a temperature of 80 °C, an acid concentration of 2 mol/L, and a hydrolysis time of 2 h. The polysaccharide structure and immune activity were then further investigated. The results showed that the PPRP comprised two fractions with approximate weights of 61,600 Da and 5500 Da. The monosaccharide composition of PPRP was mannose, rhamnose, glucose, and galactose, with a molar ratio of 1.00: 22.24: 2.93: 1.03. The major functional groups included O-H, C-H, C-O, and C-O-C. The glycosidic bond types were mainly α- and β-glycosidic bonds. Cell experiments demonstrated that PPRP could significantly increase the proliferation of macrophages and enhance the cytotoxicity of NK cells. Moreover, PPRP also significantly promoted the proliferation of B lymphocytes and T lymphocytes, especially at a concentration of 200 μg/mL. This study furnishes scientific evidence underlining the significant potential of PPRP in immune activity, thereby serving as a material basis and scientific bedrock for further investigations into the mechanism of P. portentosus oligosaccharide activity.

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Section: Introductionmentioning

confidence: 99%

Structural Characterization and Immunological Activity of Polysaccharide Degradation Products from Phlebopus portentosus

Yu,

Cai,

Wang

et al. 2024

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Chemical modifications of cellulose nanoparticles for anticancer applications: perspective since 2020

Ganie,

Dar,

Rather

et al. 2024

Cellulose

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Sustainable Synthesis of Novel Green-Based Nanoparticles for Therapeutic Interventions and Environmental Remediation

Singh,

Tiwari,

Verma

et al. 2024

ACS Synth. Biol.

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The advancement in nanotechnology has completely revolutionized various fields, including pharmaceutical sciences, and streamlined the potential therapeutic of many diseases that endanger human life. The synthesis of green nanoparticles by biological processes is an aspect of the newly emerging scientific field known as "green nanotechnology". Due to their safe, eco-friendly, nontoxic nature, green synthesis tools are better suited to produce nanoparticles between 1 and 100 nm. Nanoformulation of different types of nanoparticles has been made possible by using green production techniques and commercially feasible novel precursors, such as seed extracts, algae, and fungi, that act as potent reducing, capping, and stabilizing agents. In addition to this, the biofunctionalization of nanoparticles has also broadened its horizon in the field of environmental remediation and various novel therapeutic innovations including wound healing, antimicrobial, anticancer, and nano biosensing. However, the major challenge pertaining to green nanotechnology is the agglomeration of nanoparticles that may alter the surface topology, which can affect biological physiology, thereby contributing to system toxicity. Therefore, a thorough grasp of nanoparticle toxicity and biocompatibility is required to harness the applications of nanotechnology in therapeutics.

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Green synthesis of silver nanoparticles using Phlebopus portentosus polysaccharide and their antioxidant, antidiabetic, anticancer, and antimicrobial activities

Cited by 3 publications

References 69 publications

Structural Characterization and Immunological Activity of Polysaccharide Degradation Products from Phlebopus portentosus

Structural Characterization and Immunological Activity of Polysaccharide Degradation Products from Phlebopus portentosus

Chemical modifications of cellulose nanoparticles for anticancer applications: perspective since 2020

Sustainable Synthesis of Novel Green-Based Nanoparticles for Therapeutic Interventions and Environmental Remediation

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