Green synthesis of novel antifungal 1,2,4‐triazoles effective against γ‐irradiated Candida parapsilosis

Abstract

This study reports the green synthesis of 11 novel 3-substituted-4-amino-5mercapto-1,2,4-triazole derivatives using water as a readily available nontoxic solvent. Evaluation of their antimicrobial potential against several clinical pathogenic microorganisms was carried out. The newly synthesized cysteine derivative 6 showed promising antifungal activity against both γ-irradiated and nonirradiated Candida parapsilosis 216, with the lowest MIC (minimum inhibitory concentration) value of 3.125 µg/ml, probably through inhibition of 14α-demethylase. In addition, compound 6 showed complete inhibition of gelatinase, a virulence enzyme of C. parapsilosis. Also, scanning electron microscopy was carried out. Interestingly, compound 6 acted as a dual agent as it also showed good antibacterial activity against strains of Gram-positive bacteria used in the study. The synthesized compounds showed no cytotoxicity.

Synthesis, Antifungal Activities, Molecular Docking and Molecular Dynamic Studies of Novel Quinoxaline-Triazole Compounds

“…It contributes to the activity by the bonds it forms with the HEM in the active site of the 14-α-demethylases enzyme. When the literature is examined, it has been proven by many studies that this ring has antifungal activity. − There are literature studies showing the antifungal activities of not only 1,3,4-triazoles but also 1,2,4-triazoles and 1,2,3 triazoles. − …”

“…When the literature is examined, it has been proven by many studies that this ring has antifungal activity. 11 − 19 There are literature studies showing the antifungal activities of not only 1,3,4-triazoles but also 1,2,4-triazoles and 1,2,3 triazoles. 20 − 24 …”