Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review

Singh, Anirudh; Gautam, Pavan Kumar; Verma, Arushi; Singh, Vishal; Shivapriya, Pingali M.; Shivalkar, Saurabh; Sahoo, Amaresh Kumar; Samanta, Sintu Kumar

doi:10.1016/j.btre.2020.e00427

Cited by 367 publications

(244 citation statements)

References 117 publications

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“…One way to overcome this drawback consists on to use nanoparticles that can interact efficiently to the bacterial surface disrupting their cell wall leading to cell death. Interestingly, multifunctional nanoparticles can also interact with cellular organelles and biomolecules present in the bacteria, making difficult the resistance development against them ( 1 , 151 ).…”

Section: Msns For Infectious Diseases Treatmentmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of groundbreaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.

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Section: Msns For Infectious Diseases Treatmentmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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“…In this search, the scientific community has been focusing on the study of nanomaterials, mainly metal-based nanoparticles (NPs), to test their antimicrobial properties and feasibility to eradicate contamination sources and diseases [ 5 ]. The chemical, physical, and biological properties of NPs have been improved on the nanometer scale regarding their surface area, size, distribution, and morphology [ 6 – 8 ]. Research evidence shows that antimicrobial properties clearly depend on the synthesis method used to obtain the NPs.…”

Section: Reviewmentioning

confidence: 99%

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Correa

Martínez

Vidal

et al. 2020

Beilstein J. Nanotechnol.

106

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The investigation of novel nanoparticles with antimicrobial activity has grown in recent years due to the increased incidence of nosocomial infections occurring during hospitalization and food poisoning derived from foodborne pathogens. Antimicrobial agents are necessary in various fields in which biological contamination occurs. For example, in food packaging they are used to control food contamination by microbes, in the medical field the microbial agents are important for reducing the risk of contamination in invasive and routine interventions, and in the textile industry, they can limit the growth of microorganisms due to sweat. The combination of nanotechnology with materials that have an intrinsic antimicrobial activity can result in the development of novel antimicrobial substances. Specifically, metal-based nanoparticles have attracted much interest due to their broad effectiveness against pathogenic microorganisms due to their high surface area and high reactivity. The aim of this review was to explore the state-of-the-art in metal-based nanoparticles, focusing on their synthesis methods, types, and their antimicrobial action. Different techniques used to synthesize metal-based nanoparticles were discussed, including chemical and physical methods and “green synthesis” methods that are free of chemical agents. Although the most studied nanoparticles with antimicrobial properties are metallic or metal-oxide nanoparticles, other types of nanoparticles, such as superparamagnetic iron-oxide nanoparticles and silica-releasing systems also exhibit antimicrobial properties. Finally, since the quantification and understanding of the antimicrobial action of metal-based nanoparticles are key topics, several methods for evaluating in vitro antimicrobial activity and the most common antimicrobial mechanisms (e.g., cell damage and changes in the expression of metabolic genes) were discussed in this review.

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“…In a different way, the yeast cell wall is formed by an inner wall of β, 1-6 glucan, β, 1-3 glucan and chitin and an outer protein wall [41]. It has been reported that metallic nanoparticles are able to attach more easily to DNA and proteins [8] [13], which explains why the evaluated yeast was more resistant to the effect of AgNP and AgCuNP, which are more stable than CuNP, hence it would be easier for them to cross the yeast cell wall in an ionic state rather than its metallic state [42]. The MBC/MIC ratio has been denominated Tolerance by May, et al 2006 [43] and Das, et al 2017 [5].…”

Section: Antimicrobial Assaymentioning

confidence: 99%

Single Step Microwave Assisted Synthesis and Antimicrobial Activity of Silver, Copper and Silver-Copper Nanoparticles

Reyes-Blas¹,

Maldonado-Luna²,

Rivera-Quiñones³

et al. 2020

MSCE

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Copper and silver nanoparticles were synthesized and characterized in two minutes at 175˚C in a one-step synthesis using a modified polyol (ethylene glycol) method and a microwave heating process. We successfully synthesized spherical Silver (Ag) and Copper nanoparticles (CuNP) with a crystallite size of less than 10 nm, as well as irregular silver-copper nanoparticles (AgCuNP) with a crystallite size of less than 15 nm, as confirmed by X-Ray Diffraction (XRD) and High-Resolution Transmission Electron Microscopy (HRTEM). The successful synthesis of AgCuNP with 1:1 molar ratio and constituted by 51.74% of copper and 48.26% of silver was corroborated using the Energy Dispersive X-ray (EDX) mapping technique. The AgNP and AgCuNP exhibited more stability in suspension, in comparison to CuNP, as observed by continuously monitoring the absorbance with UV-Vis spectroscopy for 12 days. Furthermore, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgNP, CuNP, and AgCuNP were determined, against Gram-negative and Gram-positive bacteria, and yeast. The obtained MIC and MBC values indicate that AgCu nanoparticles exhibited bactericidal properties greater than its constituents. On the contrary, antifungal activity of AgCuNP against yeast was not observed.

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Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review

Cited by 367 publications

References 117 publications

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Single Step Microwave Assisted Synthesis and Antimicrobial Activity of Silver, Copper and Silver-Copper Nanoparticles

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