Green Synthesis of Gold Nanoparticles (AuNPs) As Potential Drug Carrier for Treatment and Care of Cardiac Hypertrophy Agents

Dong, Feifei; Cui, Zhengrong; Teng, Guangshuai; Shangguan, Ke; Zhang, Qing; Zhang, Guiqin

doi:10.1007/s10876-021-02003-w

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…The research claimed that using iron nanoparticles synthesized by the C. officinalis leaf would increase the cardiovascular system’s physiological activity. Another study by Dong et al (2022) [ 144 ] documented the fabrication of Imperata-cylindrica -mediated gold nanoparticles and their utility in reducing cardiomyoblastic-induced isoproterenol hypertrophy in the rat cell lines, H9c2 and 3T3.…”

Section: Therapeutic Potential Of Green Synthesized Nanoparticlesmentioning

confidence: 99%

The Ethnopharmacological Properties of Green-Engineered Metallic Nanoparticles against Metabolic Disorders

et al. 2023

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Metabolic syndrome is a multifaceted pathophysiologic condition that is largely caused by an imbalance between caloric intake and energy expenditure. The pathogenesis of metabolic syndrome is determined by an individual’s genetic/epigenetics and acquired factors. Natural compounds, notably plant extracts, have antioxidant, anti-inflammatory, and insulin-sensitizing properties and are considered to be a viable option for metabolic disorder treatment due to their low risk of side effects. However, the limited solubility, low bioavailability, and instability of these botanicals hinder their performance. These specific limitations have prompted the need for an efficient system that reduces drug degradation and loss, eliminates unwanted side effects, and boosts drug bioavailability, as well as the percentage of the drug deposited in the target areas. The quest for an enhanced (effective) drug delivery system has led to the formation of green-engineered nanoparticles, which has increased the bioavailability, biodistribution, solubility, and stability of plant-based products. The unification of plant extracts and metallic nanoparticles has helped in the development of new therapeutics against metabolic disorders such as obesity, diabetes mellitus, neurodegenerative disorders, non-alcoholic fatty liver, and cancer. The present review outlines the pathophysiology of metabolic diseases and their cures with plant-based nanomedicine.

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Section: Therapeutic Potential Of Green Synthesized Nanoparticlesmentioning

confidence: 99%

The Ethnopharmacological Properties of Green-Engineered Metallic Nanoparticles against Metabolic Disorders

et al. 2023

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“…Thereinto, gold nanoparticles (AuNPs) have been widely used in many medical aspects, such as disease diagnosis, drug detection, and cell imaging [ 8 ]. AuNPs have a certain biological activity, photothermal effect, which can also be used as a carrier to load drugs [ 9 ]. By forming the gold‐sulphur (Au‐S) coordination bond, the sulfhydryl‐containing compound can self‐assemble on the surface of the nanogold to obtain stable nanoparticles, thereby loading the drug on the surface of the nano‐gold [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer

Liujing

Wang

Zhang

2022

IET Nanobiotechnology

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The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP‐ssD@A‐E gradually increased, and the drug loading rate gradually decreased. FP‐ss@A‐E had a sustained‐release effect. Dox, Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E significantly improved cell apoptosis, in which, FP‐ssD@A‐E was the most significant. FP‐ssD@A‐E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR‐1, P‐gp, IL‐6, and i‐NOS were significantly decreased after Dox, Dox + Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E treatment. It was worth noting that FP‐ssD@A‐E had the most significant effects. The prepared FP‐ssD@A‐E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency.

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Gold Nanoparticles: Synthesis Methods, Functionalization and Biological Applications

et al. 2022

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Green Synthesis of Gold Nanoparticles (AuNPs) As Potential Drug Carrier for Treatment and Care of Cardiac Hypertrophy Agents

Cited by 6 publications

References 45 publications

The Ethnopharmacological Properties of Green-Engineered Metallic Nanoparticles against Metabolic Disorders

The Ethnopharmacological Properties of Green-Engineered Metallic Nanoparticles against Metabolic Disorders

Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer

Gold Nanoparticles: Synthesis Methods, Functionalization and Biological Applications

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