Green synthesis of gold nanoparticles via Capsicum annum fruit extract: Characterization, antiangiogenic, antioxidant and anti-inflammatory activities

Patil, Tejaswini; Vibhute, Anuja; Patil, Snehal L.; Dongale, Tukaram D.; Tiwari, Arpita

doi:10.1016/j.apsadv.2023.100372

Cited by 42 publications

(5 citation statements)

References 41 publications

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“…They are also powerful antioxidants and free radical scavengers [33]. Similar explanation also provided in the past by researchers who reported high content of phenolics, flavonoids, and tannins in the plant extract which had been used for the preparation of AuNPs [45,46].…”

Section: Quantitative Phytochemical Estimationsupporting

confidence: 65%

Exploring the antioxidant potential of a notorious weed using a microwave-based transformation to gold nanoparticles: The case of Mikania micrantha

Das,

Dwivedi,

Tiwari

et al. 2024

Preprint

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Purpose We used a notorious weed, Mikania micrantha (Asteraceae), to developed and optimize a microwave-assisted quick, single-step, cost-effective, eco-friendly, and safe approach for the biosynthesis of gold nanoparticles (AuNPs) to investigate its antioxidant potential. Methods M. micrantha AuNPs (MMAuNPs) were produced in 75 seconds under microwave irradiation. The UV-Vis spectroscopy, SEM, HR-TEM, SAED, EDX, FTIR, XRD, and DLS analysis was used to describe the AuNPs. DPPH and ABTS radical scavenging assays showed antioxidant activity. Anticancer potential was assessed by MTT assay against breast cancer cells. Swiss albino mice were tested for BBB impact by actophotometer and tail immersion. Results The synthesis of MMAuNPs was confirmed by a characteristic ruby red coloration and surface plasmon resonance peak at 534 nm. The MMAuNPs are predominantly spherical in shape, small (107.82 nm), and crystalline in nature. The antioxidant properties of the MMAuNPs were found to be better than M. micrantha aqueous extract. MMAuNPs showed anticancer potential with IC50 values of 157.1 and 174.2 µg/mL against MCF-7 and MDA-MB-231, respectively. MMAuNPs did not show a significant response of locomotor count and antinociceptive activity. Conclusion Natural creations always have a purpose, and even the most renowned weeds have something worthwhile to impart on society. The results may provide unforeseen opportunities in terms of maximizing trash usage. Nevertheless, more investigation is necessary to evaluate the in vivo effects of MMAuNPs prior to their widespread use in the field of medicine, whether as independent therapies, antioxidant, or anticancer substances, or as drug carriers.

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Section: Quantitative Phytochemical Estimationsupporting

confidence: 65%

Exploring the antioxidant potential of a notorious weed using a microwave-based transformation to gold nanoparticles: The case of Mikania micrantha

Das,

Dwivedi,

Tiwari

et al. 2024

Preprint

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“…Henceforth, their inhibition eventually causes shrinkage of tumors. The antiangiogenic moieties have been developed however often accompanied with severe side effects 49 . The phenomena of angiogenesis leading to the transition to the metastatic tumors is indeed a major challenge with regard to the anticancer therapies.…”

Section: Discussionmentioning

confidence: 99%

“…The antiangiogenic moieties have been developed however often accompanied with severe side effects. 49 The phenomena of angiogenesis leading to the transition to the metastatic tumors is indeed a major challenge with regard to the anticancer therapies. Angiogenesis is therefore a crucial phase in cancer progression as it causes rapid proliferation of cancer cells, which consume oxygen and nutrients creating local hypoxic conditions that eventually make the treatment regime ineffective.…”

Section: Discussionmentioning

confidence: 99%

Structural, vibrational, optical, and anticancer properties of Hyphaene thebaica‐reduced nano‐lanthanum oxide (La₂O₃)

Mohamed

Khalil

Hkiri

et al. 2023

Applied Organom Chemis

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Phytoextracts modulated synthesis of nano‐scaled spherical lanthanum oxide nanoparticles (La2O3 NPs) are reported using the aqueous extracts of Hyphaene thebaica as a bioreducing and chelating agent. X‐ray diffraction (XRD) pattern revealed sharp peaks and single‐phase purity. The Debye–Scherrer approximation indicated an average crystallite size of 37 nm, whereas W‐H plot revealed a crystallite size of 59 nm, complemented by the high‐resolution transmission electron microscopy (HR‐TEM). The infrared spectroscopy revealed characteristic La‐O band at 426 and 648 cm−1. K‐M function revealed the bandgap of 5.6 eV, whereas broad intense emission peaks between 345 and 750 nm. The Raman spectra revealed peaks at 182, 325, 384, and 491 cm−1. Elemental composition was confirmed using energy‐dispersive X‐ray spectroscopy (EDS) spectrum, and the spotty rings from selected area electron diffraction (SAED) indicated the crystalline nature of the HT‐La2O3 NPs. In addition, the HT‐La2O3 NPs were investigated for in vitro antioxidant, anticancer, antiangiogenic, and cytotoxic potentials. DPPH free radical scavenging activity was highest, that is, 49.54 ± 0.88% at 1000 μg/mL. MTT assay on MCF‐7 and 3T3 cell lines revealed a median lethal concentration of 114 and 43 μg/mL, respectively. The antiangiogenic effect examined by chick chorioallantoic membrane (CAM) assay indicated inhibition of 57.14 ± 0.96% at 1000‐μg/mL concentration with an IC50 of 551 μg/mL. IC50 for the brine shrimp lethality assay was 314.2 μg/mL. Our study indicates cytotoxicity of HT‐La2O3 NPs, and it further concluded that HT‐La2O3 NPs were more potent against 3T3 cells as compared with MCF‐7 cells. Further research on the biological synthesis and anticancer studies are recommended for the large‐scale applications of the La2O3 NPs.

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“…Dracocephalum kotschyi, Camellia sinensis, A. occidentale, Euphorbia peplus, Euphorbia Fischer Diana, and Musa acuminata Colla have been studied and reported. Many researchers synthesized Au NPs by utilizing plant extracts in their experiments which are effective against bacteria [145][146][147][148][149]. The body synthesizes antibodies against many diseases like chronic inflammation, and autoimmune disease in cancer treatment when the immune system is activated.…”

Section: A Nigermentioning

confidence: 99%

Breaking Barriers in Eco-Friendly Synthesis of Plant-Mediated Metal/Metal Oxide/Bimetallic Nanoparticles: Antibacterial, Anticancer, Mechanism Elucidation, and Versatile Utilizations

Dubey,

Virmani,

Yadav

et al. 2024

Journal of Nanomaterials

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Nanotechnology has emerged as a promising field in pharmaceutical research, involving producing unique nanoscale materials with sizes up to 100 nm via physiochemical and biological approaches. Nowadays more emphasis has been given to eco-friendly techniques for developing nanomaterials to enhance their biological applications and minimize health and environmental risks. With the help of green nanotechnology, a wide range of green metal, metal oxide, and bimetallic nanoparticles with distinct chemical compositions, sizes, and morphologies have been manufactured which are safe, economical, and environment friendly. Due to their biocompatibility and vast potential in biomedical (antibacterial, anticancer, antiviral, analgesic, anticoagulant, biofilm inhibitory activity) and in other fields such as (nanofertilizers, fermentative, food, and bioethanol production, construction field), green metal nanoparticles have garnered significant interest worldwide. The metal precursors combined with natural extracts such as plants, algae, fungi, and bacteria to get potent novel metal, metal oxide, and bimetallic nanoparticles such as Ag, Au, Co, Cu, Fe, Zr, Zn, Ni, Pt, Mg, Ti, Pd, Cd, Bi2O3, CeO2, Co3O4, CoFe2O4, CuO, Fe2O3, MgO, NiO, TiO2, ZnO, ZrO2, Ag-Au, Ag-Cr, Ag-Cu, Ag-Zn, Ag-CeO2, Ag-CuO, Ag-SeO2, Ag-TiO2, Ag-ZnO, Cu-Ag, Cu-Mg, Cu-Ni, Pd-Pt, Pt-Ag, ZnO-CuO, ZnO-SeO, ZnO-Se, Se-Zr, and Co-Bi2O3. These plant-mediated green nanoparticles possess excellent antibacterial and anticancer activity when tested against several microorganisms and cancer cell lines. Plants contain essential phytoconstituents (polyphenols, flavonoids, terpenoids, glycosides, alkaloids, etc.) compared to other natural sources (bacteria, fungi, and algae) in higher concentration that play a vital role in the development of green metal, metal oxide, and bimetallic nanoparticles because these plant-phytoconstituents act as a reducing, stabilizing, and capping agent and helps in the development of green nanoparticles. After concluding all these findings, this review has been designed for the first time in such a way that it imparts satisfactory knowledge about the antibacterial and anticancer activity of plant-mediated green metal, metal oxide, and bimetallic nanoparticles together, along with antibacterial and anticancer mechanisms. Additionally, it provides information about characterization techniques (UV–vis, FT-IR, DLS, XRD, SEM, TEM, BET, AFM) employed for plant-mediated nanoparticles, biomedical applications, and their role in other industries. Hence, this review provides information about the antibacterial and anticancer activity of various types of plant-mediated green metal, metal oxide, and bimetallic nanoparticles and their versatile application in diverse fields which is not covered in other pieces of literature.

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Green synthesis of gold nanoparticles via Capsicum annum fruit extract: Characterization, antiangiogenic, antioxidant and anti-inflammatory activities

Cited by 42 publications

References 41 publications

Exploring the antioxidant potential of a notorious weed using a microwave-based transformation to gold nanoparticles: The case of Mikania micrantha

Exploring the antioxidant potential of a notorious weed using a microwave-based transformation to gold nanoparticles: The case of Mikania micrantha

Structural, vibrational, optical, and anticancer properties of Hyphaene thebaica‐reduced nano‐lanthanum oxide (La₂O₃)

Breaking Barriers in Eco-Friendly Synthesis of Plant-Mediated Metal/Metal Oxide/Bimetallic Nanoparticles: Antibacterial, Anticancer, Mechanism Elucidation, and Versatile Utilizations

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Green synthesis of gold nanoparticles via Capsicum annum fruit extract: Characterization, antiangiogenic, antioxidant and anti-inflammatory activities

Cited by 42 publications

References 41 publications

Exploring the antioxidant potential of a notorious weed using a microwave-based transformation to gold nanoparticles: The case of Mikania micrantha

Exploring the antioxidant potential of a notorious weed using a microwave-based transformation to gold nanoparticles: The case of Mikania micrantha

Structural, vibrational, optical, and anticancer properties of Hyphaene thebaica‐reduced nano‐lanthanum oxide (La2O3)

Breaking Barriers in Eco-Friendly Synthesis of Plant-Mediated Metal/Metal Oxide/Bimetallic Nanoparticles: Antibacterial, Anticancer, Mechanism Elucidation, and Versatile Utilizations

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Product

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Structural, vibrational, optical, and anticancer properties of Hyphaene thebaica‐reduced nano‐lanthanum oxide (La₂O₃)