Green synthesis of gold nanoparticles using
            <i>Turnera diffusa</i>
            Willd enhanced antimicrobial properties and immune response in Longfin yellowtail leukocytes

Reyes‐Becerril, Martha; Ruvalcaba, Fernando; Sánchez, Verónica; López, Mercedes G.; Silva-Jara, Jorge Manuel; Hernández‐Adame, Luis; Angulo, Carlos

doi:10.1111/are.15184

Cited by 15 publications

(1 citation statement)

References 53 publications

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“…A key issue of AuNP synthesis is the physicochemical surface characteristics, which can determine their stability, interactions, toxicity, and biodistribution [17]. These aspects also establish the functional potential for a given biomedical application, such as antigen carriers [18].…”

Section: Introductionmentioning

confidence: 99%

LptD-antigen system on gold nanoparticles: an innovative strategy in the nanovaccine development

et al. 2022

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Nanovaccine development is a growing research field in which the development of new carriers and bioconjugation approaches is a priority. In this sense, this report describes for the first time, the development of a novel conjugate that consists of gold nanoparticles (AuNPs) obtained by a one-step synthesis using an immunogenic peptide of the Lipopolysaccharide-assembly protein LptD from Vibrio parahaemolyticus bacteria as a reducing and capping agent. The resulting LptD@AuNPs compounds were fully characterized and the results showed the high capacity of the peptide to form complexes and reduce gold ions. The reaction yield estimated was higher than 83% and the chemical integrity of the peptide on the NP surface revealed a tyrosine amino acid bonding on the AuNP surface. Furthermore, the LptD@AuNP system showed high colloidal stability in a wide pH range (3-11 pH values), where the hydrodynamic diameter and Zeta potential behavior were strongly influenced by the functional groups of the antigenic peptide. The cytotoxicity assays showed that the obtained system is safe for mouse leukocytes, while immunized mice with LptD@AuNPs produced specific IgG antibodies. These encouraging results revealed the efficacy of some antigenic peptides as reducers and capping agents, in addition, opening the path to determine immunogenicity and immunoprotective efficacy of the LptD@AuNP system against the disease induced by Vibrio parahaemolyticus.

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Section: Introductionmentioning

confidence: 99%

LptD-antigen system on gold nanoparticles: an innovative strategy in the nanovaccine development

et al. 2022

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Biogenic Synthesis of Nanomaterials and Their Therapeutic Application on Fishes

Thakur,

Bhardwaj,

Tripathi

et al. 2024

Biogenic Wastes-Enabled Nanomaterial Synthesis

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Alternative therapies recently applied in controlling farmed fish diseases: mechanisms, challenges, and prospects

Elgendy,

Ali,

Dayem

et al. 2024

Aquacult Int

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The aquaculture industry is suffering from significant financial setbacks due to an increasing frequency of disease outbreaks, posing a threat to the sector’s sustainability. Various bacterial, viral, parasitic, and fungal pathogens have led to massive mortalities in farmed fish worldwide. Throughout the years, the management of fish diseases has predominantly centered around the utilization of conventional antibiotics and chemicals. Nevertheless, their indiscriminate use has given rise to serious implications, including an increase in resistant pathogens, disruptions in the metabolic processes of fish, degradation of the aquatic environment, the presence of drug residues in aquatic products, and a potential threat to human health. Various effective bio-based and immunoprophylaxis alternative therapies have been developed to overcome these impediments. Recent alternative therapeutic approaches to fish diseases encompass a range of strategies, including phytotherapeutics, nanotherapeutics, probiotics, prebiotics, synbiotics, phage therapy, vaccination, quorum quenching, antimicrobial peptides, biosurfactants, bacteriocins, stem cells, and diagnostic-based therapy. Advancements in biotechnology have significantly enhanced the efficacy of these therapies. However, additional research is essential to refine the utilization of these therapeutic approaches. Critical concerns, such as efficacy, cost, risks, availability, and adverse effects on fish and the ecosystem, need to be addressed to establish guidelines for their sustainable application in aquaculture. This review will increase aquaculturists’ awareness of recent therapies used in fish farming, their mechanisms, challenges, and impacts while promoting the sustainability of commercial aquaculture.

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Green synthesis of gold nanoparticles using Turnera diffusa Willd enhanced antimicrobial properties and immune response in Longfin yellowtail leukocytes

Cited by 15 publications

References 53 publications

LptD-antigen system on gold nanoparticles: an innovative strategy in the nanovaccine development

LptD-antigen system on gold nanoparticles: an innovative strategy in the nanovaccine development

Biogenic Synthesis of Nanomaterials and Their Therapeutic Application on Fishes

Alternative therapies recently applied in controlling farmed fish diseases: mechanisms, challenges, and prospects

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