Green Synthesis of Chromene Congeners via Multi‐Component Reaction and Their Antimicrobial Studies

Abstract

A facile metal catalyst free, multi-component synthesis was established to afford tetrazolo dihydropyranochromenes and pyranochromeno pyridinediones in high yields starting from 7hydroxy-4-methyl coumarin, aromatic aldehydes and malononitrile based on Green chemistry principles. This protocol is applied to a wide range of aldehydes and demonstrates excellent functional group tolerance. Further, the synthesized compounds were screened in vitro against a panel of clinically relevant bacteria and fungi and found that these compounds possess moderate antimicrobial efficacy. The compounds 6 d & 7 d were exhibited very impressive antimicrobial activity against four strains of bacteria and two strains of fungi. To know more about, their mechanism of action the lead compounds were virtually screened against a key microbial enzyme, tyrosyl-tRNA (TyrRS) synthetase and found that the compounds were bound with the enzyme through various interactions and thus able to inhibit the activity of the enzyme as evidenced by their binding energies. Further, the ADMET studies of the lead compounds were showed excellent favorable Druglikeness properties when they were tested with SwissADME programme.

Design of a new unsymmetrical bis(imino)pyridine Schiff-base complexes with ionic liquid group immobilized on nano-magnetite particles in catalyzing green reactions of Chromenes as a recyclable heterogeneous catalyst: optimization using Taguchi methodology

“…Chromenes are organic compounds that are synthesized by the multi-component method [59]. In recent years, Chromenes are used in the eld of medicinal chemistry as a drug in the treatment of neurological diseases such as Alzheimer's, Huntington's, Down syndrome, etc.…”

“…In recent years, Chromenes are used in the eld of medicinal chemistry as a drug in the treatment of neurological diseases such as Alzheimer's, Huntington's, Down syndrome, etc. [60], as well as in the synthetic eld in the production of products with anti-cancer [61], antibacterial [62], anti-tuberculosis [63], antimicrobial [59], antibiotic [64] properties.…”