Green Synthesis of Chalcone Derivatives Using Chalcones as Precursor

Dhadda, Surbhi; Goswami, Prakash; Sharma, Himanshu

doi:10.5772/intechopen.103959

Cited by 2 publications

(3 citation statements)

References 62 publications

(50 reference statements)

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“…Recently, the research group of Dhadda, has applied together with the use of ionic liquids with the technique of sonication and managed to create a scheme for different synthetic heterocyclic compounds, including 2-amino-3,4-pyrimidine, pyrazole, oxazole, and pyridine derivatives. The basic ionic liquid [DBUH]OAc has proven to be the best IL since it leads to obtaining good yield of the desired result and it can also be reused for up to five catalytic cycles ( Dhadda et al, 2022 ).…”

Section: Green Solvents For the Synthesis And Derivatization Of Chalc...mentioning

confidence: 99%

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The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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The sustainable use of resources is essential in all production areas, including pharmaceuticals. However, the aspect of sustainability needs to be taken into consideration not only in the production phase, but during the whole medicinal chemistry drug discovery trajectory. The continuous progress in the fields of green chemistry and the use of artificial intelligence are contributing to the speed and effectiveness of a more sustainable drug discovery pipeline. In this light, here we review the most recent sustainable and green synthetic approaches used for the preparation and derivatization of chalcones, an important class of privileged structures and building blocks used for the preparation of new biologically active compounds with a broad spectrum of potential therapeutic applications. The literature here reported has been retrieved from the SciFinder database using the term “chalcone” as a keyword and filtering the results applying the concept: “green chemistry”, and from the Reaxys database using the keywords “chalcone” and “green”. For both databases the time-frame was 2017–2022. References were manually selected based on relevance.

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Section: Green Solvents For the Synthesis And Derivatization Of Chalc...mentioning

confidence: 99%

“…Frontiers in Chemistry frontiersin.org (Sharma et al, 2022). The click reaction can be carried out under ultrasonication to enhance the reaction rate as reported by Kaur, the reaction was performed with variably substituted aromatic azides and terminal alkynes (Figure 9E) (Kaur et al, 2022).…”

Section: Click Chemistrymentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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“…Scientists are gradually focusing more on ecofriendly methods of chemical syntheses, with particular attention to designing efficient catalysts and advancing green chemistry principles. In recent times, a number of chalcone derivatives have been synthesized utilizing ionic liquids (ILs) as both the solvents and catalysts for the ring-closure reactions of chalcones ( Dhadda et al, 2022 ). Moreover, nanocatalysts have been utilized as green alternatives to conventional catalysts in the synthesis of numerous chalcone derivatives ( Jain et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis, structure–activity relationships, in silico molecular docking, and antifungal activities of novel prenylated chalcones

Godara,

Kaushik,

Tripathi

et al. 2024

Front. Chem.

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A series of 16 novel prenylated chalcones (5A-5P) was synthesized by microwave-assisted green synthesis using 5-prenyloxy-2-hydroxyacetophenone and different benzaldehydes. Comparisons were also performed between the microwave and conventional methods in terms of the reaction times and yields of all compounds, where the reaction times in the microwave and conventional methods were 1–4 min and 12–48 h, respectively. The synthesized compounds were characterized using different spectroscopic techniques, including IR, 1H-NMR, 13C-NMR, and LC-HRMS. The antifungal activities of all compounds were evaluated against Sclerotium rolfsii and Fusarium oxysporum under in vitro conditions and were additionally supported by structure–activity relationship (SAR) and molecular docking studies. Out of the 16 compounds screened, 2’-hydroxy-4-benzyloxy-5’-O-prenylchalcone (5P) showed the highest activity against both S. rolfsii and F. oxysporum, with ED50 of 25.02 and 31.87 mg/L, respectively. The molecular docking studies of the prenylated chalcones within the active sites of the EF1α and RPB2 gene sequences and FoCut5a sequence as the respective receptors for S. rolfsii and F. oxysporum revealed the importance of the compounds, where the binding energies of the docked molecules ranged from −38.3538 to −26.6837 kcal/mol for S. rolfsii and −43.400 to −23.839 kcal/mol for F. oxysporum. Additional docking parameters showed that these compounds formed stable complexes with the protein molecules.

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Green Synthesis of Chalcone Derivatives Using Chalcones as Precursor

Cited by 2 publications

References 62 publications

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Green synthesis, structure–activity relationships, in silico molecular docking, and antifungal activities of novel prenylated chalcones

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