Green synthesis of benzochromenopyrimidines in the presence of MWCNTs@SiO2/MSA as a new and effective solid acid catalyst under microwave irradiation

Ahmadi, Masoumeh; Moradi, Leila; Sadeghzadeh, Masoud

doi:10.1016/j.molstruc.2021.130183

Cited by 9 publications

(11 citation statements)

References 36 publications

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“…In this regard, Tripathi et al 25 also reported the synthesis of 4aryloctahydro-1H-pyrano [2,3-d]pyrimidine-2(8aH)-ones/thiones 4. The three-component reaction of aromatic aldehyde 1 (1 equiv), urea/thiourea 2 (1.5 equiv), and 3,4-dihydro-(2H)pyran 3 (1 equiv) proceeded in the presence of L-proline as a Lewis acid organocatalyst, trifluoroacetic acid (TFA) as a cocatalyst, and acetonitrile (CH 3 CN) as solvent at 85 °C under reflux conditions (Scheme 1). In the absence of TFA, only a complex mixture was obtained.…”

Section: Organocatalyzed Synthesis Of Ts-1mentioning

confidence: 99%

“…In addition to this, in entry 2, aryl ortho-substituted aldehydes produced a higher yield than para-substituted aldehydes requiring a longer reaction time for completion due to steric hindrance at the ortho-position. Ahmadi et al 85 utilized multiwalled carbon nanotube surface supported by meglumine sulfonic acid as a heterogeneous solid acid catalyst (20 mg) to synthesize a novel benzochromenopyrimidine 50 analogues via equimolar reaction of 26, 11/11a, and diversified 1 without solvent using MWI (Scheme 35). The catalyst was reused five time with only slight efficiency loss.…”

Section: Copper-based Np-catalyzed Synthesismentioning

confidence: 99%

“…Ahmadi et al 85 utilized multiwalled carbon nanotube surface supported by meglumine sulfonic acid as a heterogeneous solid acid catalyst (20 mg) to synthesize a novel benzochromenopyrimidine 50 analogues via equimolar reaction of 26 , 11 / 11a , and diversified 1 without solvent using MWI ( Scheme 35 ). The catalyst was reused five time with only slight efficiency loss.…”

Section: Synthesis Of 5-aryl-substituted Pyrano[23- D ...mentioning

confidence: 99%

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Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

2023

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The pyranopyrimidine core is a key precursor for medicinal and pharmaceutical industries due to its broader synthetic applications as well as its bioavailability. Among its four possible isomers, we found that 5H-pyrano[2,3-d]pyrimidine scaffolds have a wide range of applicability, and in recent years, they have been intensively investigated, but the development of the main core is found to be more challenging due to its structural existence. In this review article, we cover all of the synthetic pathways that are employed for the development of substituted 4-aryl-octahydropyrano/hexahydrofuro[2,3-d]pyrimidin-2-one (thiones) and 5-aryl-substituted pyrano[2,3-d]pyrimidindione (2-thiones) derivatives through a one-pot multicomponent reaction using diversified hybrid catalysts such as organocatalysts, metal catalysts, ionic liquid catalysts, nanocatalysts, green solvents, catalyst-/solvent-free conditions, and miscellaneous catalysts as well as the mechanism and recyclability of the catalysts. This review mainly focuses on the application of hybrid catalysts (from 1992 to 2022) for the synthesis of 5H-pyrano[2,3-d]pyrimidine scaffolds. This review will definitely attract the world’s leading researchers to utilize broader catalytic applications for the development of lead molecules.

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Section: Organocatalyzed Synthesis Of Ts-1mentioning

confidence: 99%

Section: Copper-based Np-catalyzed Synthesismentioning

confidence: 99%

Section: Synthesis Of 5-aryl-substituted Pyrano[23- D ...mentioning

confidence: 99%

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Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

2023

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“…strategy, short reaction time, straightforward work-up, no need for chromatographic column separation, high yields, and a reusable and recyclable catalyst for more than five times. 92 In the formation of MSA/SiO 2 @MWCNTs nanocatalyst (Scheme 90), the first step is the grafting of -OH groups on the MWCNTs surfaces; raw MWCNTs were mixed in CH 2 Cl 2 in ultrasonic condition for 10 min, and S C H E M E 9 1 Plausible mechanism for the syntheses of benzochromenopyrimidines 97 using MSA/SiO 2 @MWCNTs.…”

Section: S C H E M E 8mentioning

confidence: 99%

Recent progress of nanocatalyst in the synthesis of heterocyclic compounds by barbituric acids

Safari,

Poursattar Marjani,

Sadrmohammadi

2023

Applied Organom Chemis

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Heterocycles and barbituric acid analogs are particularly used in developing and designing new drugs because of their versatile binding properties for different biotargets. They are present in many natural compounds, vitamins, drugs, and biologically active molecules such as anticancer, antibiotic, antidiabetic, anti‐inflammatory, antidepressant, anti‐HIV, antimicrobial, and insecticidal agents. Using co‐friendly techniques under nanocatalyst conditions drives the synthesis of these bioactive compounds toward green chemistry. This review will investigate the nanocatalysts, including magnetic nanocatalysts, nano metal‐based catalysts, organo‐nanocatalysts, and metal–organic frameworks (MOFs) nanocatalysts employed in the synthesis and design of heterocyclic compounds by barbituric acids from 2017 to 2022.

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“…В последние годы интерес к ресурсосберегающим процессам синтеза различных химических соединений, а в частности к реакции восстановительного аминирования сильно возрос [1-3]. Это связано с тем, что продуктом восстановительного аминирования D-глюкозы и метиламина является N-метилглюкамин, широко применяемый в медицинской химии для высокоэффективного повышения солюбилизации и стабилизации биологически активных соединений [4], используемых при лечении вирусных заболеваний [5], для лечения проблем опорно-двигательной системы человека [6], при терапии онкологических заболеваний [7], а так же используется как катализатор для [8,9]. Для увеличения скорости процесса синтеза, активности и селективности по отношению к целевому продукту, некоторые из образцов катализаторов приходится модифицировать [10,11].…”

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Modification of Nickel Catalysts for Reductive Amination Based on Polymer Supports

Михаилов¹,

Долуда²,

Sulman³

et al. 2022

Вестник Тверского Государственного Университета. Серия: Химия

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Процесс каталитической гидроконденсации является основным для синтеза огромного количества химических соединений. Примером таких соединений могут являться N-содержащие функциональные соединения, которые можно использовать в качестве исходного продукта для получения фармацевтических препаратов и агрохимикатов. За последние годы было проделано не мало исследований по поиску наиболее активного и селективного гетерогенного катализатора реакции восстановительного аминирования. Настоящая статья посвящена изучению Ni - содержащих катализаторов на основе полимерных носителей и результатам их модификации. The process of catalytic hydrocondensation is the main one for the synthesis of a huge number of chemical compounds. An example of such compounds can be N-containing functional compounds that can be used as a starting product for the production of pharmaceuticals and agrochemicals. In recent years, a lot of research has been done to find the most active and selective heterogeneous catalyst for the reductive amination reaction. This article is devoted to the study of Ni-containing polymer-supported catalysts and the results of their modification.

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Green synthesis of benzochromenopyrimidines in the presence of MWCNTs@SiO2/MSA as a new and effective solid acid catalyst under microwave irradiation

Cited by 9 publications

References 36 publications

Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

Recent progress of nanocatalyst in the synthesis of heterocyclic compounds by barbituric acids

Modification of Nickel Catalysts for Reductive Amination Based on Polymer Supports

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