Green synthesis of anisotropic silver nanoparticles from the aqueous leaf extract of Dodonaea viscosa with their antibacterial and anticancer activities

Anandan, M.; Poorani, G.; Boomi, Pandi; Varunkumar, Krishnamoorthy; Anand, Krishnan; Chuturgoon, Anil A.; Saravanan, Muthupandian; Prabu, H. Gurumallesh

doi:10.1016/j.procbio.2019.02.014

Cited by 135 publications

(48 citation statements)

References 32 publications

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“…Thus, for silver the crystallite size was 69(23) Å, and for manganese was 11.953230 Å. Our results are consistent with previous findings [1,25,30,31,[46][47][48]. However, additional peaks were observed, and they could be associated to Ag2O at 2θ values of 27°, 32°, and 44° (PDF card no.…”

Section: Xrd Analysissupporting

confidence: 91%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due to natural compounds and their potential as chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO2 nanoparticles (Ag-MnO2NPs) were synthesized using C. majus (CmNPs), V. minor (VmNPs), and a 1:1 mixture of the two extracts (MNPs). These NPs were characterized using S/TEM, EDX, XRD, and FTIR methods, and their biological activity was assessed in vitro on normal keratinocytes (HaCaT) and skin melanoma cells (A375). All synthesized NPs had manganese oxide in the middle, and silver oxide and plant extract on the exterior. The NPs had different forms (polygonal, oval, and spherical), uniformly distributed, with crystalline structures and different sizes (9.3 nm for MNPs; 10 nm for VmNPs, and 32.4 nm for CmNPs). The best results were obtained with VmNPs, which reduced the viability of A375 cells up 38.8% and had a moderate cytotoxic effect on HaCaT (46.4%) at concentrations above 500 µg/mL. At the same concentrations, CmNPs had a rather proliferative effect, whereas MNPs negatively affected both cell lines. For the first time, this paper proved the synergistic action of the combined C. majus and V. minor extracts to form small and uniformly distributed Ag-MnO2NPs with high potential for selective treatments.

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Section: Xrd Analysissupporting

confidence: 91%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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“…There was a decrease in the concentration of the amide linkage in the aqueous solution after the formation of the gold nanoparticles. The current peaks could be considered to correspond to the presence of various compounds such as phenolic, flavonoid, and carboxylic compounds, which have been reported previously …”

Section: Resultsmentioning

confidence: 99%

Chemical characterization and evaluation of antimicrobial and cutaneous wound healing potentials of gold nanoparticles usingAllium saralicumR.M. Fritsch

Hu¹,

Ahmeda

Zangeneh

2020

Applied Organom Chemis

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The use of herbal medicines dates back a long way in history. Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their good therapeutic value as they have fewer adverse effects than modern medicines. Recently, researchers have used gold nanoparticles synthesized by plants in the prevention, control, and treatment of infectious disorders and cutaneous wounds. The aims of this study were to synthesize gold nanoparticles from aqueous extract of Allium saralicum R.M. Fritsch (AuNPs) and assess their therapeutic capacities. The nanoparticles were characterized by UV–visible spectroscopy (UV–Vis), Fourier‐transform infrared (FT‐IR) spectroscopy, X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM) and transmission electron microscopy (TEM). FT‐IR results offered polysaccharides and protein in A. saralicum were the sources of reducing power, reducing gold ions to AuNPs. According to XRD analysis, the crystal size of the nanoparticles was 41.6 nm. TEM and FE‐SEM images exhibited average diameters of 45 nm for the biosynthesized nanoparticles. The synthesized AuNPs had great cell viability on HUVECs line and showed this method was nontoxic. The 2,2‐diphenyl‐1‐picrylhydrazyl free radical scavenging test indicated similar antioxidant potentials for A. saralicum, AuNPs, and butylated hydroxytoluene. To determine the antifungal and antibacterial properties of HAuCl4, A. saralicum, and AuNPs, agar diffusion tests were used. The aim of the application both HAuCl4 and A. saralicum in microbial tests was to investigate the synergism effects between them. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) were specified by macro‐broth dilution assay. AuNPs exhibited higher antifungal and antibacterial effects than all standard antibiotics (p ≤ 0.01). The MIC and MBC of AuNPs against all bacteria were in the ranges 1–4 mg/ml and 2–8 mg/ml, respectively. The MIC and MFC of AuNPs against all fungi were in the ranges 1–4 mg/ml and 2–4 mg/ml, respectively. In vivo part, AuNPs ointment group raised significantly (p ≤ 0.01) the wound contracture, vessel, hydroxyl proline, hexuronic acid, fibrocyte, fibroblast, and fibrocytes/fibroblast rate and decreased significantly (p ≤ 0.01) the wound area, total cells, and lymphocyte compared to other groups in rats. The results of FT‐IR, UV–Vis, XRD, TEM, and FE‐SEM analyses confirm that the aqueous extract of A. saralicum leaves can be used to yield gold nanoparticles with a notable amount of remedial effects without any cytotoxicity against HUVECs.

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“…Many LAB strains are able to produce various bacteriocins (Nes et al, 2007), exopolysaccharides (Cerning et al, 1999;De Vuyst et al, 1999; fatty acids, etc., exerting their beneficial health effects. Polyunsaturated fatty acids (PUFA), such as the linoleic acid (LA; 18:2Δ9Z,12Z), have inhibitory effects on growth of many bacteria (Greenway et al, 1979;Raychowdhury et al, 1985;Keweloh et al, 1996;Zheng et al, 2005). Increased concentrations of PUFA are toxic and may block native fatty acid biosynthesis via inhibition of the enoyl-ACP reductase (Greenway et al, 1979;Raychowdhury et al, 1985;Keweloh et al, 1996;Zheng et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Polyunsaturated fatty acids (PUFA), such as the linoleic acid (LA; 18:2Δ9Z,12Z), have inhibitory effects on growth of many bacteria (Greenway et al, 1979;Raychowdhury et al, 1985;Keweloh et al, 1996;Zheng et al, 2005). Increased concentrations of PUFA are toxic and may block native fatty acid biosynthesis via inhibition of the enoyl-ACP reductase (Greenway et al, 1979;Raychowdhury et al, 1985;Keweloh et al, 1996;Zheng et al, 2005). Bacteria have evolved a detoxifying mechanism and are able to enzymatically hydrogenate PUFA by a complete reduction of double bonds on the carbon chain, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Toxicity of the linoleic acid (LA; 18:2 Δ9Z,12Z) and other PUFA leads to inhibition of bacterial growth and weakens cellular membranes by blocking native fatty acid biosynthesis through inhibition of the enoyl-ACP reductase (Greenway et al, 1979;Raychowdhury et al, 1985;Keweloh et al, 1996;Zheng et al, 2005). Certain bacteria have evolved a defense mechanism to override this toxicity by enzymatically hydrogenating PUFA, i.e.…”

Section: Introductionmentioning

confidence: 99%

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Dose-dependent production of linoleic acid analogues in food derived Lactobacillus plantarum K25 and in silico characterization of relevant reactions

et al. 2020

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The objective of this study was to assess and scrutinize the competency of probiotic L. plantarum K25 to produce linoleic acid analogues in the medium supplemented with different concentrations of linoleic acid, ranging from 1% to 10%, in a dose dependent manner. The analogues produced were identified and quantitated by GC-MS and in silico studies were done to confirm enzymatic reactions involved in its conversion. The results showed that L. plantarum K25 could convert linoleic acid at different concentrations to 9 different fatty acid analogues at concentrations ranging from 0.01 to 17.24 mg/L. Among these metabolites, formation of an essential fatty acid, the linolenic acid, in media supplemented with 9% linoleic acid, is being reported for the first time. Putative candidate enzymes involved in biotransformation of linoleic acid into linoleic acid analogues were identified in the whole genome of L. plantarum K25, which was sequenced previously. In silico studies confirmed that many enzymes, including linoleate isomerase and dehydrogenase, may be involved in biotransformation of linoleic acid into linoleic acid analogues. Both enzymes could effectively bind the linoleic acid molecule, mainly by forming hydrogen bonding between the acidic groups of linoleic acid and the proline residues at the active sites of the enzymes, validating putative reaction partners.

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Green synthesis of anisotropic silver nanoparticles from the aqueous leaf extract of Dodonaea viscosa with their antibacterial and anticancer activities

Cited by 135 publications

References 32 publications

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Chemical characterization and evaluation of antimicrobial and cutaneous wound healing potentials of gold nanoparticles usingAllium saralicumR.M. Fritsch

Dose-dependent production of linoleic acid analogues in food derived Lactobacillus plantarum K25 and in silico characterization of relevant reactions

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