Green synthesis of Ag nanoparticles from <i>Leucus aspera</i> and its application in anticancer activity against alveolar cancer

Zhang, Huagen; Li, Tongfei; Luo, Wentao; Peng, Gui Xia; Xiong, Jie

doi:10.1080/17458080.2021.2007886

Cited by 23 publications

(7 citation statements)

References 61 publications

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“…The reducing agents found in C. crista seed extract, such as alcohol, phenol and alkyl halides, enabled the biofabrication of crystalline ZnO-NPs conffering significant antibacterial activities against 14 microorganisms, cytotoxicity against HeLa, MCF-7 and regular fibroblast cell lines [ 114 ]. Uniform spherical green AgNPs with antioxidant and anticancer capabilities against the alveolar carcinoma cells (A549 cells) can be obtained from Leucus aspera extract [ 115 ].…”

Section: Plant Derived Metal Nanoparticles As Anticancer Agentsmentioning

confidence: 99%

Green biologically synthesized metal nanoparticles: biological applications, optimizations and future prospects

Morgan,

Aboshanab

2024

Future Science OA

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In green biological synthesis, metal nanoparticles are produced by plants or microorganisms. Since it is ecologically friendly, economically viable and sustainable, this method is preferable to other traditional ones. For their continuous groundbreaking advancements and myriad physiochemical and biological benefits, nanotechnologies have influenced various aspects of scientific fields. Metal nanoparticles (MNPs) are the field anchor for their outstanding optical, electrical and chemical capabilities that outperform their regular-sized counterparts. This review discusses the most current biosynthesized metal nanoparticles synthesized by various organisms and their biological applications along with the key elements involved in MNP green synthesis. The review is displayed in a manner that will impart assertiveness, help the researchers to open questions, and highlight many points for conducting future research.

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Section: Plant Derived Metal Nanoparticles As Anticancer Agentsmentioning

confidence: 99%

Green biologically synthesized metal nanoparticles: biological applications, optimizations and future prospects

Morgan,

Aboshanab

2024

Future Science OA

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“…Magnetic NPs, also known as superparamagnetic iron oxide, are used in drug delivery [283,284] and hyperthermia therapy [285][286][287]. Magnetite NPs can produce receptive oxygen species (ROS), which kill microbes, making them a promising contender for an antimicrobial agent.…”

Section: Therapeutic Interventions Of Nickel Nanoparticles (Ni-nps)mentioning

confidence: 99%

“…Superparamagnetic iron oxide nanoparticles (SPIONs) provide action against the human breast cancer cell MCF7 [284]. Different nanotherapeutic studies of Fe-NPs are arranged in Table 8.…”

Section: Therapeutic Interventions Of Iron Nanoparticles (Fe-nps)mentioning

confidence: 99%

Therapeutic Perspectives of Metal Nanoformulations

Islam

Rahaman

Mia

et al. 2023

DDC

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In recent decades, acceptance of nanoparticles (NPs) in therapeutic applications has increased because of their outstanding physicochemical features. By overcoming the drawbacks of conventional therapy, the utilization of metal NPs, metal-oxide, or metal supported nanomaterials have shown to have significant therapeutic applications in medicine. This is proved by a lot of clinical and laboratory investigations that show improved treatment outcomes, site-specific drug delivery, and fewer side effects compared to traditional medicine. The metal NPs interaction with living cells (animal and plant) showed many ways to develop therapeutic models with the NPs. Despite all of the advancements that science has achieved, there is still a need to find out their performance for long-term use to solve modern challenges. In this regard, the present documentation reviews some potential metals, including silver (Ag), gold (Au), zinc (Zn), copper (Cu), iron (Fe), and nickel (Ni) NPs, as therapeutic agents in various areas such as anticancer, antimicrobial, antidiabetic, and applicable for the treatment of many other diseases. Depending on the outstanding ongoing research and practical trials, metal-based NPs can be considered the hope of prospective modern therapeutic areas.

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“…A new field of research in cancer therapeutic strategies has been made possible by major developments in nanotechnology. , Various metal oxide nanoparticles have been studied and reported in the literature for their anticancer potential. − However, zinc oxide nanoparticles (due to their unique properties) have been considered very significant among the numerous metal oxide nanoparticles . ZnO nanoparticles are potent multifunctional wide band gap n-type semiconductors.…”

Section: Introductionmentioning

confidence: 99%

Comparative In Vitro Anticancer Study of Cisplatin Drug with Green Synthesized ZnO Nanoparticles on Cervical Squamous Carcinoma (SiHa) Cell Lines

et al. 2023

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In this article, we aimed to develop a unique treatment approach to cure cervical cancer without harming healthy normal cells and overcome the limitations of currently available therapies/treatments. Recently, chemotherapeutics based on metal oxides have gained attention as a promising approach for treating cancer. Herein, ZnO nanoparticles were synthesized with the leaf extract of Azadirachta indica. These green synthesized ZnO nanoparticles were used for a cytotoxic study on the cervical squamous carcinoma cell line SiHa and murine macrophage cell line RAW 264.7. Moreover, a hemolytic assay was performed to check the biocompatibility of ZnO nanoparticles. The biosynthesized ZnO nanoparticles were labeled as L1, L2, L5, and L10 nanoparticles. Various assays like crystal violet, MTT assay, and AO/PI dual staining method were performed to assess the anticancer potential of ZnO. The concentration of ZnO nanoparticles was taken in the range of 100–250 μg/mL in the in vitro anticancer study on SiHa cancer cell lines. The findings of the MTT assay revealed that biosynthesized ZnO nanoparticles exhibited significant cytotoxicity against SiHa cancer cell lines dose-dependently at two incubation times (24 and 48 h). Also, a decrease in cell viability was observed with an increased concentration of ZnO. The IC50 values obtained were 141 μg/mL for L1, 132 μg/mL for L2, 127 μg/mL for L5, and 115 μg/mL for L10 nanoparticles. In addition, cisplatin drug (10 μg/mL) was also used to compare the anticancer activity with the biosynthesized L1, L2, L5, and L10 nanoparticles. The results of the crystal violet assay and AO/PI dual staining method revealed that morphological changes like cell shrinkage, poor cell adhesion, and induction of apoptosis occurred in the SiHa cancer cell lines. Furthermore, the stability of the ZnO nanoparticles at physiological pH has been assessed by recording the UV–visible spectrum at various pH values. Hence, the overall findings suggested that biosynthesized ZnO nanoparticles can be utilized for cervical squamous cancer treatment in addition to the current treatment strategies/techniques.

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Green synthesis of Ag nanoparticles from Leucus aspera and its application in anticancer activity against alveolar cancer

Cited by 23 publications

References 61 publications

Green biologically synthesized metal nanoparticles: biological applications, optimizations and future prospects

Green biologically synthesized metal nanoparticles: biological applications, optimizations and future prospects

Therapeutic Perspectives of Metal Nanoformulations

Comparative In Vitro Anticancer Study of Cisplatin Drug with Green Synthesized ZnO Nanoparticles on Cervical Squamous Carcinoma (SiHa) Cell Lines

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