Green synthesis of 2‐thioxo‐4‐quinazolinones from 2‐aminobenzamide and isothiocyanates
Ngoc Binh Vo,
Le Thanh Hang Nguyen,
Thi Yen Tran
et al.
Abstract:Novel green synthesis protocols of 2‐thioxo‐4‐quinazolinones starting from 2‐aminobenzamide and isothiocyanates have been reported. Method A: the reaction was carried out at 60 °C, in water, reaction time of 16 h. Method B: The reaction was carried out under solvent‐free conditions at 100 °C for 16 h. Based on these methods, six 2‐thixo‐4‐quinazolinone derivatives were synthesized with good yield. These methods have advantages, including no use of organic solvents, additives that avoid the generation of toxic … Show more
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