Green synthesis interventions of pharmaceutical industries for sustainable development

Mishra, Mohit; Sharma, Mansi; Dubey, Ravi Shanker; Kumari, Pooja; Ranjan, Vikas; Pandey, Jaya

doi:10.1016/j.crgsc.2021.100174

Cited by 36 publications

(18 citation statements)

References 9 publications

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“…Homology search of apicoplast genes cluster was performed through BLAST tool and multiple sequence alignment of the selected proteins from was performed using Clustal W. Protein domains conservation study was performed through CDD search tool at NCBI web server [31]. Finally, evolutionary relationship study was done through phylogenetic tree construction by using distance method (neighbour-joining approach) (▶Fig.…”

Section: Homology Searching Toolsmentioning

confidence: 99%

Molecular Docking Studies of Rifampicin – rpoB complex: Repurposing Drug Design Implications for against Plasmodium falciparum Malaria through a Computational Approach

Yadav

Pandey

2023

Drug Res (Stuttg)

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Malaria is one of the world’s most devastating diseases, infecting well over 300 million people annually and killing between 2 and 3 million worldwide. Increasing parasite resistance to many existing drugs is exacerbating disease. Resistance to commonly used malarial drugs is increasing the need to develop new drugs urgently. Due to the slow pace and substantial costs of new drug development, repurposing of old drugs which is recently increasingly becoming an attractive proposition of highly efficient and effective way of drug discovery led us to study the drug rifampicin for this purpose. The present paper aims to investigate the route of Plasmodium falciparum apicoplast-targeted proteins that putatively encode β subunits of RNA polymerase with an objective to develop an effective antimalarial drug. Homology searching for conserved binding site to the rifampicin drug and the functional analysis of rpoB gene were done. Multiple Sequence alignment analysis of rpoB was compared with that in E.coli – rpoB and M. tuberculosis – rpoB. Docking studies of Rifampicin – rpoB complex was also done for finding binding affinity. The results of computational studies showed that rifampicin is a potential drug for malaria.

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Section: Homology Searching Toolsmentioning

confidence: 99%

Molecular Docking Studies of Rifampicin – rpoB complex: Repurposing Drug Design Implications for against Plasmodium falciparum Malaria through a Computational Approach

Yadav

Pandey

2023

Drug Res (Stuttg)

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“…In an era where sustainability is driving industrialization and innovation, in accordance with environmental friendliness and green chemistry concepts [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], the pharmaceutical industry is at the forefront of embracing and leading change. The pharmaceutical industry’s mission is to provide patients with new medicines to help them live longer and healthier lives by creating small molecules in accordance with drug-development protocols.…”

Section: Introductionmentioning

confidence: 99%

Towards Antibiotic Synthesis in Continuous-Flow Processes

et al. 2023

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Continuous-flow chemistry has become a mainstream process and a notable trend among emerging technologies for drug synthesis. It is routinely used in academic and industrial laboratories to generate a wide variety of molecules and building blocks. The advantages it provides, in terms of safety, speed, cost efficiency and small-equipment footprint compared to analog batch processes, have been known for some time. What has become even more important in recent years is its compliance with the quality objectives that are required by drug-development protocols that integrate inline analysis and purification tools. There can be no doubt that worldwide government agencies have strongly encouraged the study and implementation of this innovative, sustainable and environmentally friendly technology. In this brief review, we list and evaluate the development and applications of continuous-flow processes for antibiotic synthesis. This work spans the period of 2012–2022 and highlights the main cases in which either active ingredients or their intermediates were produced under continuous flow. We hope that this manuscript will provide an overview of the field and a starting point for a deeper understanding of the impact of flow chemistry on the broad panorama of antibiotic synthesis.

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“… 1 Among the chemical manufacturers, the pharmaceutical industry is lagging behind other industries in tackling the green transition because of the high value of their products. 2 Nevertheless, the climate crisis is so serious that all sectors need to revise their production strategies to protect the planet. In the field of active pharmaceutical ingredients (APIs) and key intermediates for pharmaceuticals, many studies have been devoted to the replacement of toxic reagents and harmful materials with greener and safer chemicals for the development of more sustainable procedures.…”

Section: Introductionmentioning

confidence: 99%

“…This attitude not only is an exercise in style but also is driven by the need for robust synthetic platforms and more sustainable and efficient protocols . Among the chemical manufacturers, the pharmaceutical industry is lagging behind other industries in tackling the green transition because of the high value of their products . Nevertheless, the climate crisis is so serious that all sectors need to revise their production strategies to protect the planet.…”

Section: Introductionmentioning

confidence: 99%

Photoredox Cross-Dehydrogenative Coupling of N-Aryl Glycines Mediated by Mesoporous Graphitic Carbon Nitride: An Environmentally Friendly Approach to the Synthesis of Non-Proteinogenic α-Amino Acids (NPAAs) Decorated with Indoles

et al. 2022

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Indole-decorated glycine derivatives are prepared through an environmentally benign cross-dehydrogenative coupling between N -aryl glycine analogues and indoles (yield of ≤81%). Merging heterogeneous organocatalysis and photocatalysis, C–H functionalization has been achieved by selective C-2 oxidation of N -aryl glycines to afford the electrophilic imine followed by Friedel–Crafts alkylation with indole. The sustainability of the process has been taken into account in the reaction design through the implementation of a metal-free recyclable heterogeneous photocatalyst and a green reaction medium. Scale-up of the benchmark reaction (gram scale, yield of 69%) and recycling experiments (over seven runs without a loss of efficiency) have been performed to prove the robustness of the protocol. Finally, mechanistic studies were conducted employing electron paramagnetic resonance spectroscopy to unveil the roles of the photocatalyst and oxygen in the formation of odd-electron species.

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Green synthesis interventions of pharmaceutical industries for sustainable development

Cited by 36 publications

References 9 publications

Molecular Docking Studies of Rifampicin – rpoB complex: Repurposing Drug Design Implications for against Plasmodium falciparum Malaria through a Computational Approach

Molecular Docking Studies of Rifampicin – rpoB complex: Repurposing Drug Design Implications for against Plasmodium falciparum Malaria through a Computational Approach

Towards Antibiotic Synthesis in Continuous-Flow Processes

Photoredox Cross-Dehydrogenative Coupling of N-Aryl Glycines Mediated by Mesoporous Graphitic Carbon Nitride: An Environmentally Friendly Approach to the Synthesis of Non-Proteinogenic α-Amino Acids (NPAAs) Decorated with Indoles

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