Green synthesis approach for novel benzenesulfonamide nanometer complexes with elaborated spectral, theoretical and biological treatments

Abstract

New series of nano‐sized bi‐homonuclear Ce (III), ZrO (II), Sn (II), Pb (II), Cr (III), Fe (III) and Cu (II) complexes with 4‐[(2,4‐dihydroxybenzylidene)amino]‐N‐(1,3‐thiazol‐2‐yl) benzenesulfonamide (H3L) were synthesized via green solid‐state method. The structural and molecular formulae of all synthesized complexes were established based on variable spectral, analytical and theoretical implementations. FT‐IR study confirms the coordination of H3L with metal ions through the Schiff base and sulfonamide centers in di‐basic tetra‐dentate mode. Thermal analysis, magnetic moment and electronic spectra are attributing to octahedral configuration around Ce (III), Cr (III) and Fe (III) centers, while with ZrO (II), Sn (II), Pb (II) and Cu (II) centers, acquired tetrahedral arrangement. TEM and XRD studies, represent the nanometer characters of most metal ion complexes. TGA curves are utilized to compute the activation thermo‐kinetic parameters over different decomposition stages applying Coats‐Redfern method. Theoretical implementation executed by Gaussian09 program exerted the structures for the best atomic orientation over whole molecules. QSAR data were achieved over Hyper Chem 8.1 program through molecular mechanics process. Docking complexes between free ligand and different protein receptors were obtained through AutoDock Tools 4.2. Antimicrobial, antifungal and antitumor activities of the metal complexes were studied in comparing with free ligand to assert their potential therapeutic uses. H3L, Ce (III), Fe (III) and Cu (II) complexes displayed high antibacterial activity near that of standard Gentamycin. Moreover, Cr (III) complex displayed highest cytotoxicity against human liver Carcinoma cell line (HEPG2).

Nano‐synthesis, solid‐state structural characterization, and antimicrobial and anticancer assessment of new sulfafurazole azo dye‐based metal complexes for further pharmacological applications

“…[1] Excessive doses of these substances cause allergic reactions in a variety of bodily organs, [2,3] as well as lymphadenopathy, hepatotoxicity, and hematological problems. [4] New functionalized sulfonamide derivatives and their metal chelates [5][6][7][8] were enforced in clinical investigations to overcome such problems and manufacture efficient medications. In most cases, novel metal sulfonamide chelates demonstrate much efficacy than the medications that they were derived from.…”

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

“…Tz-41 was examined against bacteria (E. coli and S. aureus) and fungi (C. albicans and A. fumigates) by the agar well diffusion method. The result showed the same inhibition zone for Tz-41 and the free ligand in E. coli (15 mm), and it was even lower in C. albicans (13 mm and 15 mm), with no activity in S. aureus and A. fumigates [109]. Tz-42 was reported as a mononuclear complex consisting of a Schiff base-type tetradentate ligand and a central copper atom with square planar geometry.…”

Newly synthesised Schiff base metal complexes, characterisation, and contribution as enhancers of colon cancer cell apoptosis by overexpression of P53 protein

“…Owing to π‐π* and n‐π* transitions, groups of ultraviolet spectra to H 2 Enro‐o‐phdn and its chelates, respectively, are found to range from 269 to 336 nm (Figure S2). 31,49 The shift of π‐π* and n‐π* transition in the spectra of the complexes demonstrating that the chelation of H 2 Enro‐o‐phdn to metal ions 36,50 . The new bands in the range 457–489 nm in the chelates' electronic absorption spectra were recognizable to ligand's metal charge transfer ability 50 .…”

“…36,50 The new bands in the range 457-489 nm in the chelates' electronic absorption spectra were recognizable to ligand's metal charge transfer ability. 50 The iron (III) complex absorption spectrum displayed band at 564 nm, which may be ascribed to 6 A 1 ! 4 T 2 ( 4 G) transition (Table 3).…”