Green Synthesis and Characterization of Silver Nanoparticles Using Moringa Peregrina and Their Toxicity on MCF-7 and Caco-2 Human Cancer Cells

Abstract

Introduction The synthesis of nanoparticles using naturally occurring reagents such as vitamins, sugars, plant extracts, biodegradable polymers and microorganisms as reductants and capping agents could be considered attractive for nanotechnology. These syntheses have led to the fabrication of limited number of inorganic nanoparticles. Among the reagents mentioned above, plant-based materials seem to be the best candidates, and they are suitable for large-scale biosynthesis of nanoparticles. Methods The aqueous extract of Moringa peregrina leaves was used to synthesize silver nanoparticles. The synthesized nanoparticles were characterized by various spectral studies including FT-IR, SEM, HR-TEM and XRD. In addition, the antioxidant activity of the silver nanoparticles was studied viz . DPPH, ABTS, hydroxyl radical scavenging, superoxide radical scavenging, nitric oxide scavenging potential and reducing power with varied concentrations. The anticancer potential of the nanoparticles was also studied against MCF-7 and Caco-2 cancer cell lines. Results The results showed that silver nanoparticles displayed strong antioxidant activity compared with gallic acid. Furthermore, the anticancer potential of the nanoparticles against MCF-7 and Caco-2 in comparison with the standard Doxorubicin revealed that the silver nanoparticles produced significant toxic effects against the studied cancer cell lines with the IC 50 values of 41.59 (Caco-2) and 26.93 (MCF-7) µg/mL. Conclusion In conclusion, the biosynthesized nanoparticles using M. peregrina leaf aqueous extract as a reducing agent showed good antioxidant and anticancer potential on human cancer cells and can be used in biological applications.

From lab to field: Prussian blue frameworks as sustainable cathode materials

“…Furthermore, composite methodologies enable the incorpor-ation of dopants or foreign species in their crystal networks, thereby presenting a potential avenue for doping-induced modifications of magnetic, electronic, and optical characteristics. 41 This adaptability opens novel prospects in the domain of advanced materials, which possess the capability to modify their functionalities to match various technical applications.…”

“…Furthermore, composite methodologies enable the incorporation of dopants or foreign species in their crystal networks, thereby presenting a potential avenue for doping-induced modifications of magnetic, electronic, and optical characteristics. 41 This adaptability opens novel prospects in the domain of advanced materials, which possess the capability to modify their functionalities to match various technical applications. In addition, template-assisted synthesis elucidates the underlying mechanisms that govern the formation and growth of PB and its analogues, thereby bolstering the foundation for the relationship between structural properties.…”