Green Synthesis and Biological Assessments of Silver Nanoparticles Using the Plant Extract of Crataegus sinaica Boiss. Fruits

El-Shahaby, O. A.; Reicha, Fikry M.; Aboushadi, Maged Mohamed Nabil; El-Zayat, Mustafa

doi:10.33945/sami/pcbr.2020.2.3

Cited by 8 publications

(3 citation statements)

References 26 publications

(21 reference statements)

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“…Studies have shown that extremely high concentrations of metal ions such as Cu 2+ , Zn 2+ , and Fe 2+ can bind to Aβ and co-localize with amyloid plaques [ 113 ]. Therefore, the use of metal chelators for AD treatment, for example, clioquinol (CQ), is of considerable interest, but most chelators can also chelate other metal-containing proteins, which is undesirable and can lead to the disruption of normal physiological functions in the body [ 114 , 115 ]. It has been repeatedly demonstrated that SeNP can bind to Aβ and affect metal ions and modify their surfaces, including ligands, charges, or reactivity [ 116 , 117 ].…”

Section: The Role Of Senp In Medicine and Human Healthmentioning

confidence: 99%

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Varlamova

Turovsky

Блинова

2021

IJMS

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This review presents the latest data on the importance of selenium nanoparticles in human health, their use in medicine, and the main known methods of their production by various methods. In recent years, a multifaceted study of nanoscale complexes in medicine, including selenium nanoparticles, has become very important in view of a number of positive features that make it possible to create new drugs based on them or significantly improve the properties of existing drugs. It is known that selenium is an essential trace element that is part of key antioxidant enzymes. In mammals, there are 25 selenoproteins, in which selenium is a key component of the active site. The important role of selenium in human health has been repeatedly proven by several hundred works in the past few decades; in recent years, the study of selenium nanocomplexes has become the focus of researchers. A large amount of accumulated data requires generalization and systematization in order to improve understanding of the key mechanisms and prospects for the use of selenium nanoparticles in medicine, which is the purpose of this review.

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Section: The Role Of Senp In Medicine and Human Healthmentioning

confidence: 99%

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Varlamova

Turovsky

Блинова

2021

IJMS

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“…Green synthesis of nanomaterials using plant extracts as a furious source of natural compounds like carbohydrates, phenolics, flavonoids, tannins, and alkaloids [ 9 , 10 ] that could act as safe reducing and stabilizing agents in addition to their ability to maintaining aseptic environments throughout the process [ 11 , 12 ]. Therefore, medicinal plants of therapeutic potential could control the dimensions and forms of the biosynthesized nanomaterial [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Antimicrobial, Antioxidant, and Anticancer Activity of Greenly Synthesized Selenium and Zinc Composite Nanoparticles Using Ephedra aphylla Extract

et al. 2021

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The current work aimed to synthesize selenium and zinc nanoparticles using the aqueous extract of Ephedra aphylla as a valuable medicinal plant. The prepared nanoparticles were characterized by TEM, zeta potential, and changes in the phytochemical constituents. Hence, the phenolic, flavonoid, and tannin contents were reduced in the case of the prepared samples of nanoparticles than the original values in the aqueous extract. The prepared extract of Ephedra aphylla and its selenium and zinc nanoparticles showed high potency as antioxidant agents as a result of the DPPH• assay. The samples were assessed as anticancer agents against six tumor cells and a normal lung fibroblast (WI-38) cell line. The selenium nanoparticles of Ephedra aphylla extract revealed very strong cytotoxicity against HePG-2 cells (inhibitory concentration (IC50) = 7.56 ± 0.6 µg/mL), HCT-116 cells (IC50 = 10.02 ± 0.9 µg/mL), and HeLa cells (IC50 = 9.23 ± 0.8 µg/mL). The samples were evaluated as antimicrobial agents against bacterial and fungal strains. Thus, selenium nanoparticles showed potent activities against Gram-negative strains (Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli), Gram-positive strains (Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus, and Staphylococcus epidermidis), and the fungal strain Candida albicans. In conclusion, the preparation of nanoparticles of either selenium or zinc is crucial for improved biological characteristics.

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“…The green protocols for the synthesis of metal nanoparticles from the extracts of natural plant sources, investigation of their change in the phytochemical contents, and characterization of the metal nanoparticles were recently reported [61][62][63][64].…”

Section: Resultsmentioning

confidence: 99%

Anticancer and Antioxidant Activity of the Greenly Synthesized Zinc Nanoparticles Composites using Aqueous Extract of Withania Somnifera plant

Dhabian

Jasim

2021

Egypt. J. Chem.

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Withania somnifera L. is a medicinal herb related to Solanaceae family, known as ashwagandha. The aqueous extract of W. somnifera was utilized for the green synthesis of zinc nanoparticles to investigated their antioxidant and anticancer potentials. The synthesized zinc nanoparticle solution of W. somnifera extract was characterized by phytochemical analysis, Transmission Electron Microscope (TEM), and zeta potential. The results revealed reduced values of the phytochemical constitutes, large surface area, and high stability of the nanoparticles. The antioxidant activity of the extracted W. somnifera and its zinc nanoparticles was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) assay, in which the original extract has the more antioxidant capacity with IC50= 0.701 mg/mL, along with potent results for both samples relative to ascorbic acid. The extracted W. somnifera, its zinc nanoparticles, and zinc sulfate solution were in vitro assessed as anticancer agents on wellknown six human tumor, and a normal cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The results demonstrated that the synthesized zinc nanoparticles of the W. somnifera extract shown the most potent cytotoxicity with IC50= 19.17 µg/mL on HeLa cell line. The synthesized nano-zinc solution of the W. somnifera aqueous extract performed to be proficient as a potent anticancer characteristic than the plant extract with developed biological potency.

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Green Synthesis and Biological Assessments of Silver Nanoparticles Using the Plant Extract of Crataegus sinaica Boiss. Fruits

Cited by 8 publications

References 26 publications

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

The Antimicrobial, Antioxidant, and Anticancer Activity of Greenly Synthesized Selenium and Zinc Composite Nanoparticles Using Ephedra aphylla Extract

Anticancer and Antioxidant Activity of the Greenly Synthesized Zinc Nanoparticles Composites using Aqueous Extract of Withania Somnifera plant

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