Green synthesis and antifungal effect of titanium dioxide nanoparticles on oral Candida albicans pathogen

Moradpoor, Hedaiat; Safaei, Mohsen; Golshah, Amin; Mozaffari, Hamid Reza; Sharifi, Roohollah; Imani, Mohammad Moslem; Mobarakeh, Mohammad Salmani

doi:10.1016/j.inoche.2021.108748

Cited by 17 publications

(8 citation statements)

References 19 publications

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“…e culture medium was sterilized in an autoclave and then an isolated bacterial colony was added to the Erlenmeyer flasks. Erlenmeyer flasks containing bacteria and culture medium were incubated at 37 °C for 48 h. To isolate the bacteria from the culture medium, centrifugation was performed at 5000 rpm for 5 min and the supernatant from the precipitate was detached and used for the produce of nanoparticles [21]. Nine experiments were planned to optimize the synthesis conditions of selenium NPs by Taguchi method [22].…”

Section: Methodsmentioning

confidence: 99%

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Optimization of Green Synthesis of Selenium Nanoparticles and Evaluation of Their Antifungal Activity against Oral Candida albicans Infection

Safaei

Mozaffari

Moradpoor

et al. 2022

Advances in Materials Science and Engineering

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Increasing resistance of microbes to available antimicrobial agents has necessitated the production of new compounds with wider activity and lower toxicity. Candida is one of the pathogenic fungal strains that are highly prevalent in oral diseases. The goal of this study was to optimize the biosynthesis of selenium nanoparticles (NPs) with the suitable antifungal activity on Candida albicans oral pathogen. For this purpose, selenium NPs were synthesized by the green method using the Halomonas elongata bacterium. To optimally synthesize NPs with the maximal antifungal properties, 9 experiments were planned applying the Taguchi method. In the planned experiments, the efficacy of 3 factors, sodium selenite concentration, glucose concentration, and incubation time at 3 various levels was studied, and the most desirable conditions with the suitable performance were determined. Then, optimizing the synthesis of the studied nanoparticles, their properties were evaluated using Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), electron transmission microscopy (TEM), and thermogravimetric analysis (TGA) to confirm the synthesis of nanoparticles with suitable conditions. The results demonstrated that the synthesized NPs in the experiment 9 condition showed the best performance and prevented more than 70% of fungal growth. Since selenium NPs were effective as an antifungal agent, they can be used in the structure of mouthwashes as an antimicrobial agent in the prevention and treatment of many oral diseases.

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Section: Methodsmentioning

confidence: 99%

“…e nanoparticles produced by centrifugation were separated and purified at 5000 rpm for 15 min. e obtained solutions were then placed in an oven at 80 °C for 24 h to provide nanoparticles for structural analysis [21].…”

Section: Methodsmentioning

confidence: 99%

Optimization of Green Synthesis of Selenium Nanoparticles and Evaluation of Their Antifungal Activity against Oral Candida albicans Infection

Safaei

Mozaffari

Moradpoor

et al. 2022

Advances in Materials Science and Engineering

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“…The formation of Au-NPs in the sample was evident from the change in solution color from light yellow to ruby red. As light passes through the nanoparticles in the sample, the sample absorbs specific wavelengths, and the intensity of wavelengths is reduced in the beam emitted from the sample [ 19 ]. Monitoring the reaction kinetics using UV-vis spectroscopy confirmed the completion of the reaction in the sample after 3 min, as evident from the stability, with no further significant change beyond this time ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Process Optimization for the Bioinspired Synthesis of Gold Nanoparticles Using Cordyceps militaris, Its Characterization, and Assessment of Enhanced Therapeutic Efficacy

Gawas,

Ayyanar,

Gurav

et al. 2023

Pharmaceuticals

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The promising therapeutic implications of nanoparticles have spurred their development for biomedical applications. An eco-friendly methodology synthesizes gold nanoparticles using Cordyceps militaris, an edible mushroom (Cord-Au-NPs), using a quality-by-design approach (central composite design). UV-visible spectroscopy analysis revealed an absorption peak at 540–550 nm, thus confirming the synthesis of gold nanoparticles. Cord-Au-NPs have a crystalline structure, as evidenced by the diffraction peaks. The zeta potential value of −19.42 mV signifies the stability of Cord-Au-NPs. XRD study shows gold facets and EDX analysis revealed a strong peak of spherical nanoparticles in the gold region with a mean particle size of 7.18 nm and a polydispersity index of 0.096. The obtained peaks are closely associated with phenolic groups, lipids, and proteins, as examined by FTIR, suggesting that they function as the reducing agent. Cord-Au-NPs exhibited dose-dependent antioxidant, antidiabetic, and antibacterial activity. The method is eco-friendly, nontoxic, less time-consuming, and does not use synthetic materials, leading to higher capabilities in biomedical applications.

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“…Moradpoor et al synthesized TiO 2 NPs via a green approach by Bacillus sp. Bacteria [ 120 ]. According to the findings, TiO 2 NPs produced under green conditions inhibit fungus from growing by 73% (oral Candida albicans pathogen).…”

Section: Inorganic Nanomaterials As Anti Caries Agentmentioning

confidence: 99%

Recent advances in the use of inorganic nanomaterials as anti caries agents

Al-Hijazi¹,

Hasan²,

Nasr³

et al. 2023

Heliyon

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Green synthesis and antifungal effect of titanium dioxide nanoparticles on oral Candida albicans pathogen

Cited by 17 publications

References 19 publications

Optimization of Green Synthesis of Selenium Nanoparticles and Evaluation of Their Antifungal Activity against Oral Candida albicans Infection

Optimization of Green Synthesis of Selenium Nanoparticles and Evaluation of Their Antifungal Activity against Oral Candida albicans Infection

Process Optimization for the Bioinspired Synthesis of Gold Nanoparticles Using Cordyceps militaris, Its Characterization, and Assessment of Enhanced Therapeutic Efficacy

Recent advances in the use of inorganic nanomaterials as anti caries agents

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