Abstract:Objective: The main goal of this work was to evaluate the therapeutic potential of green SPIONs produced with coconut water for treating cutaneous leishmaniasis caused by Leishmania amazonensis. Materials and methods: Optical and electron microscopy techniques were used to evaluate the effects on cell proliferation, infectivity percentage, and ultrastructure. Results: SPIONs were internalized by both parasite stages, randomly distributed by the cytosol located mainly in membrane-bound compartments. The selecti… Show more
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