Green silver nanoparticles functionalised gelatin nanocomposite film for wound healing: Construction and characterization

Sheokand, B.; Pathak, Seema R.; Srivastava, Chander Mohan; Kumar, Anuj; Bahadur, Indra; Vats, Monika

doi:10.1016/j.molliq.2022.120561

Cited by 11 publications

(8 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…216 Polymeric nanoparticles of natural origin in combination with biomolecules, growth factors, and drugs to create scaffolds with improved mechanical strength could also solve the limitations of the present wound healing materials. 217 Antibacterial and biodegradable nanoparticles are combined to develop hybrid nanocomposite which may enhance healing of wounds. To ensure low resistance and quick healing, one has to be aware of the primary difficulties associated with nanomaterial wound dressings and how they interact with the injury.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

“…The utilization of natural polymers in combination with blood components, growth factors, or cells that simulate synergistic therapeutic processes and stimulate crucial regeneration systems beneficial in healing is an effective option in the wound‐care field 216 . Polymeric nanoparticles of natural origin in combination with biomolecules, growth factors, and drugs to create scaffolds with improved mechanical strength could also solve the limitations of the present wound healing materials 217 . Antibacterial and biodegradable nanoparticles are combined to develop hybrid nanocomposite which may enhance healing of wounds.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

See 1 more Smart Citation

Natural polymers used in the dressing materials for wound healing: Past, present and future

Sheokand

Vats²,

Kumar³

et al. 2023

Journal of Polymer Science

View full text Add to dashboard Cite

Wound healing is a complicated system that necessitates an appropriate environment to aid healing. Wound dressing is among the most important external variables in wound repair. Technology advancements have led to the creation of a variety of dressings that treat various wound types by focusing on the four stages of wound healing. Simplicity of application, sterility, antibacterial, non‐adherent, gaseous exchange, non‐toxicity, and other qualities are necessary for wound dressings. In order to fully regenerate and restore the structure and functionality of the skin, the ideal dressing should address the demands of the wound. So, the kind of wound dressing used is based on the type of injury. This review focuses on the different types of natural polymers such as κ‐carrageenan, chitosan, cellulose, gelatin, collagen, alginate, hyaluronic acid, and silk fibroin used in the development of dressing materials such as hydrogels, nanofibers, sponges, films, and various other types of scaffolds owing to their features, for example, biocompatibility, biodegradability, and similarity to human extracellular matrix (ECM) which aids in the healing process. The commercially available products based on these natural polymers are also discussed in the review. However, the majority of the natural polymer‐based wound dressings still exhibit a number of problems like adherence, opaque, fast degradability, and lack of multifunctionality, thus these need to be addressed. A naturally inspired smart wound dressing is the need of the hour which aids in individual stages of healing by monitoring the multiple wound variables such as pH, temperature, electrical potentials and eases the incorporated drug and biological molecules as per wound healing progress with a variety of delivery systems.

show abstract

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Natural polymers used in the dressing materials for wound healing: Past, present and future

Sheokand

Vats²,

Kumar³

et al. 2023

Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

“…These polymers mimic the natural extracellular matrix, facilitating cell interaction, migration, and tissue regeneration. [122,123] Their hydrophilic nature promotes water retention and solubility of protein biologics, maintaining the conformational stability critical for therapeutic efficacy. [124,125] While conventional hydrogels rely solely on diffusion for protein release, affinity-based hydrogels utilize a reaction-diffusion mechanism driven by ligand-protein interactions.…”

Section: Tuning Polymer Physicochemical Properties Prolongs Drug Phar...mentioning

confidence: 99%

Long‐Acting Ocular Injectables: Are We Looking In The Right Direction?

Dang,

Shoichet

2023

Advanced Science

View full text Add to dashboard Cite

The complex anatomy and physiological barriers of the eye make delivering ocular therapeutics challenging. Generally, effective drug delivery to the eye is hindered by rapid clearance and limited drug bioavailability. Biomaterial‐based approaches have emerged to enhance drug delivery to ocular tissues and overcome existing limitations. In this review, some of the most promising long‐acting injectables (LAIs) in ocular drug delivery are explored, focusing on novel design strategies to improve therapeutic outcomes. LAIs are designed to enable sustained therapeutic effects, thereby extending local drug residence time and facilitating controlled and targeted drug delivery. Moreover, LAIs can be engineered to enhance drug targeting and penetration across ocular physiological barriers.

show abstract

“…1,2 In wound healing, natural polymers are engineered as delivery systems for cells and pharmaceuticals, 3,4 scaffolds for tissue repair and regeneration, 5 and dressings for different wound types. 6 Advancements in these areas are reported in the scientific literature, as illustrated by the study reported by Liu et al The authors designed a silk fibroin (SF) sponge suitable for wound healing. The sponge exhibited a highly porous structure with micro and nanosized pores.…”

Section: Introductionmentioning

confidence: 99%

Analyzing the interactions and miscibility of silk fibroin/mucin blends

Lopes,

Ottaiano,

de Souza Guedes

et al. 2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Mucin, a glycoprotein with viscoelastic properties, and silk fibroin, a protein excreted from silkworms with properties of thermal and mechanical resistance, have been probed as building blocks in the design of biomaterials. Aiming to evaluate the interaction and miscibility between mucin and fibroin, we synthesized silk fibroin and mucin (SF/MU) blends for biomedical applications. The morphological analysis of the SF/MU blends showed the presence of two phases, suggesting a partial miscibility between the polymers. The degradation temperature of the SF/MU blends increased with an increase in the silk fibroin content, indicating that silk fibroin contributed to the thermal stability of the blends. The glass transition temperature of the SF/MU blends lay between the values of the pure polymers. The Fourier‐transform infrared spectroscopy results pointed out that the interaction between fibroin and mucin occurred between the amine group of silk fibroin and mucin carboxyl and hydroxyl groups. The outcomes of this work provided essential information on the miscibility of the SF/MU blends. These findings will be critical for further studies with fibroin and mucin‐based biomaterials, especially in mucoadhesive systems and wound healing applications.

show abstract

Green silver nanoparticles functionalised gelatin nanocomposite film for wound healing: Construction and characterization

Cited by 11 publications

References 48 publications

Natural polymers used in the dressing materials for wound healing: Past, present and future

Natural polymers used in the dressing materials for wound healing: Past, present and future

Long‐Acting Ocular Injectables: Are We Looking In The Right Direction?

Analyzing the interactions and miscibility of silk fibroin/mucin blends

Contact Info

Product

Resources

About