Abstract:Inorganic nanomedicines in the fight against cancer have progressed rapidly during recent years, with the synergistic advantages of multifunctional nanosystems compared to single component. Herein, a drug-combination opinion was introduced into “nanomedicine” based on the understanding of Trojan horse-anti-tumor mechanism of inorganic nano-medicines. Moreover, we reported the green and facile synthesis route of mono-dispersed and rod-like zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites. We found that … Show more
“…It has to be noticed that, recently, nanomaterials containing cadmium reveal a bactericidal effect owing to Cd 2+ release [11,43] being used in the biological area [44,45]. However, till now, only few studies were focused on the photocatalytic and biological properties of composites based on ZnO-CdS [46,47], ZnO-CdS-Ag [48], Cd:Ag:ZnO [49], and ZnO/Cd (OH)Cl [50]. The results of these works show the huge potential of such composites in different application areas, ranging from wastewater treatment to antimicrobials.…”
In this work, ZnO–CdS composite powders synthesized by a simple chemical precipitation method were thoroughly characterized. The morphological, structural, compositional, photocatalytical, and biological properties of the prepared composites were investigated in comparison with those of the pristine components and correlated with the CdS concentration. ZnO–CdS composites contain flower-like structures, their size being tuned by the CdS amount added during the chemical synthesis. The photocatalytic activity of the composites was analyzed under UV irradiation using powders impregnated with methylene blue; the tests confirming that the presence of CdS along the ZnO in composites can improve the dye discoloration. The biological properties such as antioxidant capacity, antibacterial activity, and cytotoxicity of the ZnO, CdS, and ZnO–CdS composites were evaluated. Thus, the obtained composites presented medium antioxidant effect, biocidal activity against Escherichia coli, and no toxicity (at concentrations less than 0.05 mg/mL for composites with a low CdS amount) for human fibroblast cells. Based on these results, such composites can be used as photocatalytic and/or biocidal additives for photoactive coatings, paints, or epoxy floors, which in their turn can provide a cleaner and healthier environment.
“…It has to be noticed that, recently, nanomaterials containing cadmium reveal a bactericidal effect owing to Cd 2+ release [11,43] being used in the biological area [44,45]. However, till now, only few studies were focused on the photocatalytic and biological properties of composites based on ZnO-CdS [46,47], ZnO-CdS-Ag [48], Cd:Ag:ZnO [49], and ZnO/Cd (OH)Cl [50]. The results of these works show the huge potential of such composites in different application areas, ranging from wastewater treatment to antimicrobials.…”
In this work, ZnO–CdS composite powders synthesized by a simple chemical precipitation method were thoroughly characterized. The morphological, structural, compositional, photocatalytical, and biological properties of the prepared composites were investigated in comparison with those of the pristine components and correlated with the CdS concentration. ZnO–CdS composites contain flower-like structures, their size being tuned by the CdS amount added during the chemical synthesis. The photocatalytic activity of the composites was analyzed under UV irradiation using powders impregnated with methylene blue; the tests confirming that the presence of CdS along the ZnO in composites can improve the dye discoloration. The biological properties such as antioxidant capacity, antibacterial activity, and cytotoxicity of the ZnO, CdS, and ZnO–CdS composites were evaluated. Thus, the obtained composites presented medium antioxidant effect, biocidal activity against Escherichia coli, and no toxicity (at concentrations less than 0.05 mg/mL for composites with a low CdS amount) for human fibroblast cells. Based on these results, such composites can be used as photocatalytic and/or biocidal additives for photoactive coatings, paints, or epoxy floors, which in their turn can provide a cleaner and healthier environment.
“…Figure 4 shows the FTIR spectrum of electrospun C-Zein and DES-Zein nanofibers. C-Zein showed a significant peak at 3,289 cm −1 due to –NH stretching, while DES-Zein showed intensive and broad stretching peak at 3,303 cm −1 due to the strong hydrogen bonding between –OH from Choline chloride/furfuryl-alcohol moiety and –NH from Zein polymer 15 , 16 , 22 . Figure 4 FTIR spectrum of C-Zein and DES-Zein with proposed chemical structure.…”
Section: Resultsmentioning
confidence: 99%
“…Figure 4 shows the FTIR spectrum of electrospun C-Zein and DES-Zein nanofibers. C-Zein showed a significant peak at 3,289 cm −1 due to -NH stretching, while DES- www.nature.com/scientificreports/ Zein showed intensive and broad stretching peak at 3,303 cm −1 due to the strong hydrogen bonding between -OH from Choline chloride/furfuryl-alcohol moiety and -NH from Zein polymer 15,16,22 . The intense bands at 2,875 cm −1 and 2,960 cm −1 due to the asymmetric and symmetric C-H stretching in the spectrum of DES-Zein nanofibers, which may be due to the induced dipole moment caused by the change in solvent polarity comparing to C-Zein nanofibers.…”
Section: Influence Of Electrospinning Parameters On Morphology Of Desmentioning
The use of organic solvents for the preparation of nanofibers are challenged due to their volatile and hazardous behavior. Recently deep eutectic solvents (DES) are widely recognized as non-volatile and non-hazardous solvents which never been utilized directly for nanofabrication via electrospinning. Here, we present the preparation of Zein nanofibers using deep eutectic solvents (DES-Zein). The DES-Zein nanofibers were produced at an optimized polymer concentration of 45% (w/w) with pH 7.3 and electroconductivity 233 mS cm−1. DES-Zein nanofibers showed aligned to tweed like cedar leaf morphology tuned by varying the spreading angle from 0° to 90°. In contrast to hydrophobic conventional Zein nanofibers, DES-Zein nanofibers showed super hydrophilic character and about 200 nm finer average diameter. The proposed method of preparing Zein nanofibers using DES opens a new door to continuous electrospinning with tunable morphology, having potential to be used for environmental and biomedical applications.
“…Zein is a major storage protein of corn, with the advantages of excellent cell compatibility, easy fabrication technology and better mechanical properties . There are cumulative reports to show that zein is a cytocompatible material both in vitro and in vivo . It can be degraded into polypeptide or amino acids by various proteases, which are also nontoxic .…”
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