Green Seaweed Polysaccharides Inventory of Nador Lagoon in North East Morocco

Asri, Ouahid El; Ramdani, Mohamed; Fadlaoui, Soufiane

doi:10.1002/9781119711414.ch8

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…Based on the SEM results, the ability of PCT to scavenge free radicals is probably related to its rough surface morphology. According to Ouahid et al [ 52 ], C. tomentosum is classified as the second producer of sulfated polysaccharides. This sulfated polysaccharide can prevent the accumulation of free radicals and denature these reactive chemical species.…”

Section: Resultsmentioning

confidence: 99%

Anti-Vasculogenic, Antioxidant, and Anti-Inflammatory Activities of Sulfated Polysaccharide Derived from Codium tomentosum: Pharmacokinetic Assay

Lakhrem,

Eleroui,

Boujhoud

et al. 2024

Pharmaceuticals

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The purpose of this paper was to investigate the anti-inflammatory and anti-angiogenic activities of sulfated polysaccharide from C. tomentosum (PCT) using carrageenan (CARR)-induced paw edema in a rat model and anti-vasculogenic activity on a chorioallantoic membrane assay (CAM) model. Based on in vitro tests of anti-radical, total antioxidant, and reducing power activities, PCT presents a real interest via its antioxidant activity and ability to scavenge radical species. The in vivo pharmacological tests suggest that PCT possesses anti-inflammatory action by reducing paw edema and leukocyte migration, maintaining the redox equilibrium, and stabilizing the cellular level of several pro-/antioxidant system markers. It could significantly decrease the malondialdehyde levels and increase superoxide dismutase, glutathione peroxidase, and glutathione activities in local paw edema and erythrocytes during the acute inflammatory reaction of CARR. PCT pretreatment was effective against DNA alterations in the blood lymphocytes of inflamed rats and reduced the hematological alteration by restoring blood parameters to normal levels. The anti-angiogenic activity results revealed that CAM neovascularization, defined as the formation of new vessel numbers and branching patterns, was decreased by PCT in a dose-dependent manner, which supported the in silico bioavailability and pharmacokinetic findings. These results indicated the therapeutic effects of polysaccharides from C. tomentosum and their possible use as anti-proliferative molecules based on their antioxidant, anti-inflammatory, and anti-angiogenic activities.

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Section: Resultsmentioning

confidence: 99%