Green, rapid and efficient synthesis of new antibacterial pyridopyrimidinone mediated by eutectic mixture of Urea/CuCl2

On the Role of Water in the Formation of a Deep Eutectic Solvent Based on NiCl2·6H2O and Urea

“…However, the impact of water on the DES structure and properties can provide a plethora of different situations depending on the specific system, leaving an amount of unanswered questions. − This circumstance has the potential impact of undermining even the definition at the base of this class of solvents, as it was recently shown for the archetypal DES reline for which, under dry conditions, an MP of ca . 32 °C was obtained, which is much higher than the originally determined one. , In the framework of MDES formation, some confusion in the present literature exists on the employment of either the anhydrous or the hydrated form of the metal salt, or on the control of the water uptake in the operating conditions. − ,, These issues, together with the well-known hygroscopicity of many metal chloride salts, induce suspicion about the effective hydration extent of the employed starting materials and on a possible involvement of water in the eutectic formation. In this framework, note that “type I” and “type II” DESs differ only with one being the hydrated form of the other …”

“…This MDES commensurate with the archetypal “type IV” ZnCl 2 :urea 1:3.5 presented by Abbott and co-workers, 12 though an analogous CuCl 2 :urea 1:3.5 has been more recently proposed. 26 In these works, it seems that the eutectic phase has been achieved with the anhydrous form of the metal salt, while very recently, various MDESs of lanthanide nitrates and urea still in the 1:3.5 molar ratio have been obtained with the hydrated form. 28 In our opinion, this opens the question about the role played by water in the formation and in the structural arrangement of the MDES.…”

“…24,25 In the framework of MDES formation, some confusion in the present literature exists on the employment of either the anhydrous or the hydrated form of the metal salt, or on the control of the water uptake in the operating conditions. [6][7][8][9]26,27 These issues, together with the well-known hygroscopicity of many metal chloride salts, induce suspicion about the effective hydration extent of the employed starting materials and on a possible involvement of water in the eutectic formation. In this framework, note that "type I" and "type II" DESs differ only with one being the hydrated form of the other.…”

Synthesis, antimicrobial evaluation, crystal structure, Hirschfeld surface analysis and docking studies of 4-[2-(1-methyl-1H-imidazol-2-ylsulfanyl)-acetylamino]-benzenesulfonic acid

“…This research was performed because of our experience with the synthesis and characterisation of novel active heterocyclic compounds [24][25][26][27][28][29][30][31]. The main objective was the preparation, biological evaluation and crystal structural identification of a new, imidazolecontaining molecule: 4-[2-(1-methyl-1H-imidazol-2-ylsulfanyl)-acetylamino]-benzenesulfonic acid (hereafter, "5").…”