Green Protocols for the Synthesis of 3,3’-spirooxindoles – 2016- mid 2019

Abstract

Spirooxindoles, particularly 3,3’-spirooxindoles constitute a privileged structural scaffold owing to the intensive biological activities which they possess. Because of this over the last twenty years, a large number of methods were devised for their synthesis and some of these molecules have entered pre-clinical trials. Of late, methods for spirooxindole synthesis using green protocols have developed rapidly. Reactions based on multicomponent strategies using non-catalytic / biocatalytic pathways and those done in aqueous media have been largely employed for the synthesis of 3,3’- spirooxindoles. This review focusses on the synthesis of 3,3’-spirooxindoles via green protocols and covers the literature from 2016 onwards (2016 - mid 2019); a review on the same topic has appeared in 2016. The green methods discussed here include reactions done in aqueous media, multicomponent strategies, alternate solvents and photocatalysis.

Novel cellulose supported 1,2-bis(4-aminophenylthio)ethane Ni(ii) complex (NiII(BAPTE)(NO3)2-Cell) as an efficient nanocatalyst for the synthesis of spirooxindole derivatives

“…[74][75][76] These ring systems have been used regularly as a scaffold in medicinal and agricultural chemistry. [77][78][79][80] Synthesis of spirooxindoles is an interesting subject in synthetic chemistry due to their pharmacological activities such as anticancer, anti-HIV, anti-tuberculosis, antifungal, antibacterial and anti-malarial properties.…”

Transition metal-catalyzed synthesis of spirooxindoles

“…Previously, reviews were reported on the synthesis of spirooxindole via green protocols. 28 In addition, several other reviews are available on the catalytic asymmetric synthesis of spirooxindole. [29][30][31] In the present review, we highlight the transition metal-catalyzed synthesis of spirooxindoles up to 2020.…”