Green protocol for annulation of the s-triazine ring on thiazoles using a three-component coupling strategy

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Disposable and Flexible Electrochemical Paper‐based Analytical Devices Using Low‐cost Conductive Ink

“…The use of the HRP enzyme immobilized on the electrodes increases the sensitivity of phenolic compounds detection [54]. The enzyme mechanism involved in HRP-based biosensor for HQ detection consists in the oxidation of enzyme molecules by hydrogen peroxide, so HRP is reduced in two steps by the redox mediator [55], in this case, HQ. This last reduction converts HQ to benzoquinone which is electroactive and can be reduced on the electrode surface [56].…”

Biorenewable Resources in the Biginelli Reaction: Cerium(III)-Catalyzed Synthesis of Novel Iminosugar-Annulated Perhydropyrimidines

“…19 An additional reason for which we have been spurred to use aldoses in the Biginelli reaction stems from the desire to achieve a degree of internal asymmetric induction and thus obtain diastereomerically pure sugar-annulated perhydropyrimidines as the biological activity of DHPMs is strictly dependent on the absolute configuration at C-4 stereocenter. 14,20 The present work is part of our continuous drive to devise new one-pot, solvent-free cyclization processes, [21][22][23][24][25] especially involving stereocontrolled protocols. 23,24 The 3cc strategy reported herein was successfully realized by MW irradiation of an intimate solvent-free mixture of 2-phenyl-1,3-oxazol-5-one (1), D-xylose/D-glucose 2, urea/thiourea 3 and Ce(III) salt in a CEM Discover Focused Microwave Synthesis System at 90 °C for the time specified in Table 1 (Scheme 1).…”

Multicomponent reactions in chiral ionic liquids: A stereocontrolled route to mercaptopyranothiazoles

“…As part of our ongoing research programme and continued interest in devising new solvent-free cyclization processes [35][36][37][38][39], we had to develop an efficient synthetic approach to pyranothiazoles incorporating a thiol function at C-6. For this purpose, we utilized the mercaptoacetyl transfer agent, 2-methyl-2-phenyl-1,3oxathiolan-5-one ( Figure 1) [38], which leads to the desired mercaptoacetylative heteroannulation and is the key element in the present successful synthetic strategy for the target compounds 4 (Scheme 1).…”