Green profile tools: Current status and future perspectives

Locatelli, Marcello; Kabir, Abuzar; Perrucci, Miryam; Ulusoy, Songül; Ulusoy, Halil İ̇brahim; Ali, Imran

doi:10.1016/j.sampre.2023.100068

Cited by 33 publications

(2 citation statements)

References 46 publications

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“…The ComplexGAPI tool was applied for the evaluation of the green character of the developed procedure. This metric not only allows the evaluation of the analytical protocol in terms of its environmental friendliness but also those processes which precede the analytical procedure itself ( Płotka-Wasylka and Wojnowski, 2021 ; Locatelli et al, 2023 ). And so, the greenness aspect of the following parameters was evaluated: yield, conditions, reagents and solvents, instrumentation and workup, and purification which may occur before analytical protocol.…”

Section: Resultsmentioning

confidence: 99%

Deep eutectic solvent-based shaking-assisted extraction for determination of bioactive compounds from Norway spruce roots

Kalyniukova,

Várfalvyová,

Płotka-Wasylka

et al. 2024

Front. Chem.

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Polyphenolic compounds play an essential role in plant growth, reproduction, and defense mechanisms against pathogens and environmental stresses. Extracting these compounds is the initial step in assessing phytochemical changes, where the choice of extraction method significantly influences the extracted analytes. However, due to environmental factors, analyzing numerous samples is necessary for statistically significant results, often leading to the use of harmful organic solvents for extraction. Therefore, in this study, a novel DES-based shaking-assisted extraction procedure for the separation of polyphenolic compounds from plant samples followed by LC-ESI-QTOF-MS analysis was developed. The DES was prepared from choline chloride (ChCl) as the hydrogen bond acceptor (HBA) and fructose (Fru) as the hydrogen bond donor (HBD) at various molar ratios with the addition of 30% water to reduce viscosity. Several experimental variables affecting extraction efficiency were studied and optimized using one-variable-at-a-time (OVAT) and confirmed by response surface design (RS). Nearly the same experimental conditions were obtained using both optimization methods and were set as follows: 30 mg of sample, 300 mg of ChCl:Fru 1:2 DES containing 30% w/w of water, 500 rpm shaking speed, 30 min extraction time, 10°C extraction temperature. The results were compared with those obtained using conventional solvents, such as ethanol, methanol and water, whereby the DES-based shaking-assisted extraction method showed a higher efficiency than the classical procedures. The greenness of the developed method was compared with the greenness of existing procedures for the extraction of polyphenolic substances from solid plant samples using the complementary green analytical procedure index (ComplexGAPI) approach, while the results for the developed method were better or comparable to the existing ones. In addition, the practicability of the developed procedure was evaluated by application of the blue applicability grade index (BAGI) metric. The developed procedure was applied to the determination of spruce root samples with satisfactory results and has the potential for use in the analysis of similar plant samples.

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Section: Resultsmentioning

confidence: 99%

Deep eutectic solvent-based shaking-assisted extraction for determination of bioactive compounds from Norway spruce roots

Kalyniukova,

Várfalvyová,

Płotka-Wasylka

et al. 2024

Front. Chem.

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“…Minimal amounts of such contaminants can impact the drug's effectiveness and safety. The medicine's safety is determined not only by the toxicological qualities of the active pharmaceutical ingredient as well as by the impurities it currently incorporates [1] . Detecting, separating, and assessing these contaminants is crucial in drug manufacturing and regulatory assessments.…”

Section: Introductionmentioning

confidence: 99%

Greenness-sustainability metrics for assessment smart-chemometric spectrophotometric strategy for evaluation of the combination of six gastric proton-pump inhibitors with two selected impurities

Amin

2024

MethodsX

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Novel pillar[n]arenes magnetic nanoparticles: Preparation and application in quantitative analysis of trace perfluorinated compounds from aqueous samples

Liu,

Ma,

et al. 2024

Analytica Chimica Acta

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Green profile tools: Current status and future perspectives

Cited by 33 publications

References 46 publications

Deep eutectic solvent-based shaking-assisted extraction for determination of bioactive compounds from Norway spruce roots

Deep eutectic solvent-based shaking-assisted extraction for determination of bioactive compounds from Norway spruce roots

Greenness-sustainability metrics for assessment smart-chemometric spectrophotometric strategy for evaluation of the combination of six gastric proton-pump inhibitors with two selected impurities

Novel pillar[n]arenes magnetic nanoparticles: Preparation and application in quantitative analysis of trace perfluorinated compounds from aqueous samples

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