Green Preparation and Structure Elucidation of Spiro Indole Derivatives Using Grindstone Technique

Abstract

Grindstone Chemistry technique or Toda's solvent-free green method of grinding reactants together has been successfully applied for conducting multicomponent reaction of 1H-indole-2,3-dione, malononitrile and 2-thioxo-4-thiazolidinone for the synthesis of Spiro indole derivatives. The reaction conditions have been studied and compared with conventional methods in terms of reaction time, yield and workup procedure. Grinding takes only 15 minutes to complete the reaction. The synthesized compounds have been characterized by IR, 1HNMR, and 13 CNMR spectra.

One pot synthesis of some novel indole derivatives and their antimicrobial activity

“…In addition, they are readily available at low cost and increase the reactivity of reaction intermediate 13 . The reaction in which more than two components are mixed in one pot from the desired compound is called a one-pot multicomponent reaction 14 . These reactions are beneficial because of less solvent waste 15 , less time, and less environmental impact compared to a step-bystep reaction 16 .…”