Green polymer hydrogels from a natural monomer with inherent antioxidative capability for efficient wound healing and spinal cord injury treatment

Du, Jiaqiang; Wang, Fang; Li, Jiaxi; Yang, Yuxuan; Guo, Dong; Zhang, Yanfeng; Yang, Aimin; He, Xijing; Cheng, Yilong

doi:10.1039/d3bm00174a

Cited by 10 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, some researchers have successfully prepared a polylipoic acid-sodium lipoate hydrogel (PLAS) with desirable mechanical properties, easy injectability, and sufficient adhesion. Animal experiments have revealed that PLAS can effectively eliminate cellular ROS, thereby promoting recovery from spinal cord injury ( 149 ).…”

Section: Ros Removal In Materials Science Developmentmentioning

confidence: 99%

ROS: Executioner of regulating cell death in spinal cord injury

Yin,

Wan,

Gong

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

The damage to the central nervous system and dysfunction of the body caused by spinal cord injury (SCI) are extremely severe. The pathological process of SCI is accompanied by inflammation and injury to nerve cells. Current evidence suggests that oxidative stress, resulting from an increase in the production of reactive oxygen species (ROS) and an imbalance in its clearance, plays a significant role in the secondary damage during SCI. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial regulatory molecule for cellular redox. This review summarizes recent advancements in the regulation of ROS-Nrf2 signaling and focuses on the interaction between ROS and the regulation of different modes of neuronal cell death after SCI, such as apoptosis, autophagy, pyroptosis, and ferroptosis. Furthermore, we highlight the pathways through which materials science, including exosomes, hydrogels, and nanomaterials, can alleviate SCI by modulating ROS production and clearance. This review provides valuable insights and directions for reducing neuronal cell death and alleviating SCI through the regulation of ROS and oxidative stress.

show abstract

Section: Ros Removal In Materials Science Developmentmentioning

confidence: 99%

ROS: Executioner of regulating cell death in spinal cord injury

Yin,

Wan,

Gong

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Liu et al constructed a gelatin-modified hydrogel laden with NSCs and albumin-incubated CeO2 nanoparticles, which could promote neurogenesis via alleviating oxidative stress microenvironments and improving the viability of encapsulated NSCs [112]. The hydrogel prepared by Du et al via polymerization of α-lipoic acid had inherent antioxidant capacity and can effectively provide wound-healing and spinal cord injury treatment, removing ROS from the injury site [113]. Thus, the antioxidant function of injectable hydrogels provides a new therapeutic idea for the treatment of SCI.…”

Section: Antioxidantmentioning

confidence: 99%

Application of Injectable Hydrogels as Delivery Systems in Spinal Cord Injury

Ji,

Hao,

Wang

et al. 2023

Gels

View full text Add to dashboard Cite

Spinal cord injury (SCI) is a severe neurological injury caused by traffic accidents, trauma, or falls, which leads to significant loss of sensory, motor, and autonomous functions and seriously affects the patient’s life quality. Although considerable progress has been made in mitigating secondary injury and promoting the regeneration/repair of SCI, the therapeutic effects need to be improved due to drug availability. Given their good biocompatibility, biodegradability, and low immunogenicity, injectable hydrogels can be used as delivery systems to achieve controlled release of drugs and other substances (cells and proteins, etc.), offering new hope for SCI repair. In this article, we summarized the types of injectable hydrogels, analyzed their application as delivery systems in SCI, and further discussed the mechanisms of hydrogels in the treatment of SCI, such as anti-inflammatory, antioxidant, anti-apoptosis, and pro-neurogenesis. Moreover, we highlighted the potential benefits of hydrogels in the treatment of SCI in combination with therapies, including the recent advances and achievements of these promising tools. Our review may offer new strategies for the development of SCI treatments based on injectable hydrogels as delivery systems.

show abstract

“…This holistic approach to hydrogel design not only effectively modulated oxidative stress and inflammation at the application site but also facilitated the migration and differentiation of NSCs into neurons, thereby amplifying the regenerative potential of the hydrogel system. Furthermore, biomaterials with similar structures that lack conductivity properties have also shown promise as SCI treatments [44] …”

Section: Ros‐targeted Biomaterials For Sci Treatmentmentioning

confidence: 99%

“…Furthermore, biomaterials with similar structures that lack conductivity properties have also shown promise as SCI treatments. [44] Inspired by the ROS-cleavable ability of thioketal diamine, Li et al designed and fabricated a thioketalcontaining ROS-scavenging hydrogel. [45] Several classical analytical techniques, such as DPPH scavenging analysis, H 2 O 2 scavenging analysis, and O 2 − scavenging analysis, were used to assess the ROS-clearing functions of the hydrogel.…”

Section: Organic Ros-core Biomaterials For Sci Treatmentmentioning

confidence: 99%

Reactive oxygen species targeted biomaterials for spinal cord injury therapy

Zuo,

Ying,

Huang

et al. 2023

Brain-X

View full text Add to dashboard Cite

Spinal cord injuries (SCIs) often cause individuals to suffer from painful illnesses and debilitating disabilities. Excessive reactive oxygen species (ROS) generation in injured tissues hampers treatment effectiveness. Unfortunately, there is presently no established clinical remedy for addressing SCI, particularly the injuries related to ROS. However, the materials science and technology field has made remarkable progress, resulting in the development of a wide range of biomaterials with unique properties for regulating ROS. This review aims to summarize the latest advancements in ROS‐targeted biomaterials designed specifically for the treatment of SCIs. Key scientific challenges in the evolution of ROS‐targeted neuroprotection strategies are also discussed. We anticipate that this comprehensive summary will be valuable to new researchers and highlight specific future avenues of research, contributing to the further advancement of ROS‐targeted biomaterials for SCI treatment.

show abstract

Green polymer hydrogels from a natural monomer with inherent antioxidative capability for efficient wound healing and spinal cord injury treatment

Abstract: Development of polymeric hydrogels with multiple functions (adhesiveness, self-healability, antioxidation, etc.) through one-step green polymerization of naturally occurring small molecules in water is critical for various biomedical applications and clinical...

Cited by 10 publications

References 57 publications

ROS: Executioner of regulating cell death in spinal cord injury

ROS: Executioner of regulating cell death in spinal cord injury

Application of Injectable Hydrogels as Delivery Systems in Spinal Cord Injury

Reactive oxygen species targeted biomaterials for spinal cord injury therapy

Contact Info

Product

Resources

About