Green Oxidation Reactions of Drugs Catalyzed by Bio-inspired Complexes as an Efficient Methodology to Obtain New Active Molecules

Faria, Emerson H. de; Ricci, Gustavo Pimenta; Lemos, Frederico Matias; Silva, Márcio Luís Andrade e; Filho, Ademar Alves da Silva; Calefi, Paulo S.; Nassar, Eduardo J.; Ciuffi, Kátia J.

doi:10.5772/13524

Cited by 1 publication

(2 citation statements)

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“…In the metalloporphyrins/O 2 system (Figure S6, Supporting Information), supported metalloporphyrin catalyst Co(III)D( p -Cl)PPCl/ZnO loses a chlorine radical to form Co(II)D( p -Cl)PP•/ZnO, which combines with an oxygen molecule to form an activated radical species Co(III)OOD( p -Cl)PP•/ZnO and then form O–O active species (Co(III)D( p -Cl)PP/ZnO) 2 OO. The intermediate Co(IV)OD( p -Cl)PP•/ZnO can easily capture a hydrogen atom from cyclohexane to afford an alkyl radical and then form the products. , The chlorine radical can also easily capture a hydrogen atom from cyclohexane to afford an alkyl radical, which combines with an oxygen molecule to form the activated peroxoradicals species (ROO•); then it may form organic acids. The existence of the different supports hindered the supported catalysts and dioxygen to form the active species Co(IV)OD( p -Cl)PP•/ZnO, which can capture a hydrogen atom from cyclohexane to afford an alkyl radical and then form the products.…”

Section: Resultsmentioning

confidence: 99%

“…In the metalloporphyrins/O 2 system (Figure S6 can easily capture a hydrogen atom from cyclohexane to afford an alkyl radical and then form the products. 22,30 The chlorine radical can also easily capture a hydrogen atom from cyclohexane to afford an alkyl radical, which combines with an oxygen molecule to form the activated peroxoradicals species (ROO•); then it may form organic acids. The existence of the different supports hindered the supported catalysts and dioxygen to form the active species Co(IV)OD(p-Cl)PP•/ ZnO, which can capture a hydrogen atom from cyclohexane to afford an alkyl radical and then form the products.…”

Section: Resultsmentioning

confidence: 99%

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Zinc Oxide Supported trans-CoD(p-Cl)PPCl-Type Metalloporphyrins Catalyst for Cyclohexane Oxidation to Cyclohexanol and Cyclohexanone with High Yield

Xie

Zhang

Liu

et al. 2015

Ind. Eng. Chem. Res.

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Direct functionalization of saturated C-H bonds by metalloporphyrin catalysts is among the topical and challenging areas within the chemical industry and the synthetic chemistry. In this work, supported CoD(p-Cl)PPCl metalloporphyrin catalysts were prepared and characterized. It has been found that the CoD(p-Cl)PPCl/ZnO catalyst shows better catalytic activity than the supported catalyst (ZrO 2 , MCM-41, kaolin, Zr(OH) 2 and BM) in cyclohexane oxidation with dioxygen. The effects of the reaction pressure, reaction temperature and reaction time on the catalytic activity were considered by the supported CoD(p-Cl)PPCl/ZnO catalyst. The CoD(p-Cl)PPCl/ZnO catalyst can be facilely recovered and was recycled up to seven times without significant decrease in catalytic performance. The average cyclohexane conversion and selectivity to KA oil are 10.98% and 84.34% respectively, and the turnover number is 2.10 x 10 7 .

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%