Green miniaturized technologies in analytical and bioanalytical chemistry

Agrawal, Arpana; Keçili, Rüstem; Ghorbani‐Bidkorbeh, Fatemeh; Hussain, Chaudhery Mustansar

doi:10.1016/j.trac.2021.116383

Cited by 72 publications

(21 citation statements)

References 175 publications

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“…Green miniaturized sample preparation is preferred, wherein environmentally friendly extraction phases are used [ 54 ]. Additionally, microextraction is also preferred over traditionally used extraction procedures.…”

Section: The Perspective and Concluding Remarksmentioning

confidence: 99%

Techniques for analytical estimation of COVID‐19 clinical candidate, niclosamide in pharmaceutical and biomedical samples

Gupta

Bharate

2022

Separation Science Plus

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Niclosamide is a well‐known broad‐spectrum antiparasitic drug used for human as well as veterinary tapeworm infections. Recently, it attracted attention as an antiviral agent for treating coronavirus disease 2019. It is administered orally in humans to treat tapeworm infections. Furthermore, it is a registered pesticide and molluscicide to control infections in the aquaculture industry. Its chronic environmental exposure has potential toxicities when such contaminated seafood is consumed. Therefore, monitoring its residual concentration in food products (seafood, water, water waste, etc.) and pharmaceuticals (active pharmaceutical ingredients, bulk drugs, and formulations) is imperative. The present review critically investigates the sophisticated techniques employed for analyzing niclosamide, its degradation products, and metabolites in various samples and matrices. The future scope for green analytical methods, green sample extraction and preparation is also deliberated.

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Section: The Perspective and Concluding Remarksmentioning

confidence: 99%

Techniques for analytical estimation of COVID‐19 clinical candidate, niclosamide in pharmaceutical and biomedical samples

Gupta

Bharate

2022

Separation Science Plus

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“…However, these techniques use a large volume of organic solvents and generate a high number of residues, which may cause some environmental concerns. For this reason, the field of analytical chemistry is currently tending toward miniaturized methodologies that enable the objectives of green analytical chemistry (GAC) [ 8 , 9 ]. Currently, there are not many works using microextractive techniques in the determination of TAs in foods.…”

Section: Introductionmentioning

confidence: 99%

Improved Analytical Approach for Determination of Tropane Alkaloids in Leafy Vegetables Based on µ-QuEChERS Combined with HPLC-MS/MS

González-Gómez

Morante‐Zarcero

Câmara

et al. 2022

Toxins

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This work presents an optimized methodology based on the miniaturization of the original QuEChERS (μ-QuEChERS) followed by liquid chromatography coupled to mass spectrometry (HPLC-MS/MS) for the determination of tropane alkaloids (TAs), atropine, and scopolamine in leafy vegetable samples. The analytical methodology was successfully validated, demonstrating quantitation limits (MQL) ≤2.3 ng/g, good accuracy, and precision, with recoveries between 90–100% and RSD ≤ 13% for both analytes. The method was applied to the analysis of TA-producing plants (Brugmansia versicolor, Solandra maxima, and Convolvulus arvensis). High concentrations of scopolamine were found in flowers (1771 mg/kg) and leaves (297 mg/kg) of B. versicolor. The highest concentration of atropine was found in flowers of S. maxima (10.4 mg/kg). Commercial mixed leafy vegetables contaminated with B. versicolor and S. maxima were analysed to verify the efficacy of the method, showing recoveries between 82 and 110% for both analytes. Finally, the method was applied to the analysis of eighteen samples of leafy vegetables, finding atropine in three samples of mixed leafy vegetables, with concentrations of 2.7, 3.2, and 3.4 ng/g, and in nine samples with concentrations ≤MQL. In turn, scopolamine was only found in a sample of chopped Swiss chard with a concentration ≤MQL.

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“…Its results can also complement other methods of characterization, such as X-ray diffraction (XRD) [3] or Raman [2]. The analysis of materials at atomic resolution is becoming more relevant with the development of miniaturized systems in multiple domains such as electronics [4], chemistry [5] or metallurgy [6]. Most of these systems rely on the use of nano-engineered materials such as thin films [7] or more complex patterned structures [8].…”

Section: Introductionmentioning

confidence: 99%

FIB and Wedge Polishing Sample Preparation for TEM Analysis of Sol-Gel Derived Perovskite Thin Films

et al. 2022

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In ceramic thin films, choosing an appropriate sample preparation method for transmission electron microscopy (TEM) analyses is of paramount importance to avoid preparation-induced damage and retain nanoscale features that require investigation. Here we compare two methods of TEM thin film sample preparation, namely conventional wedge polishing and focused ion beam (FIB) based lift out preparation applied to ferroelectric barium titanate (BaTiO3, BT) thin films made by chemical solution deposition (CSD). The aim of the work is to determine the pros and cons of each method considering not only the quality of the TEM specimen, but also aspects such as availability, ease of use, and affordability. Besides some limitations on the selection of visualized area due to thickness constraints on the FIB-made sample, both methods offer the capability to prepare samples with very comparable quality, as indicated by achieving the same thickness, a largely agreeing microstructure, no secondary phases on the diffraction pattern, and good atomic resolution. This last observation is especially important in the current context of material science, where more nanoscale phenomena are becoming the subject of study. The wedge polishing method, however, is deemed more affordable in terms of instrumentation, as it only requires a tripod polisher, a polishing wheel, and a precision ion polishing system, whereas the lift out method requires a scanning electron microscope (SEM) equipped with an FIB system. We believe that this work serves groups working on ferroelectric thin films in preparing TEM samples in a more effective and uncomplicated manner, facilitating progress in understanding this fascinating class of materials.

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Green miniaturized technologies in analytical and bioanalytical chemistry

Cited by 72 publications

References 175 publications

Techniques for analytical estimation of COVID‐19 clinical candidate, niclosamide in pharmaceutical and biomedical samples

Techniques for analytical estimation of COVID‐19 clinical candidate, niclosamide in pharmaceutical and biomedical samples

Improved Analytical Approach for Determination of Tropane Alkaloids in Leafy Vegetables Based on µ-QuEChERS Combined with HPLC-MS/MS

FIB and Wedge Polishing Sample Preparation for TEM Analysis of Sol-Gel Derived Perovskite Thin Films

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