Green Mechanochemical Strategy for the Construction of a New Bio-based Nylon 5₂4T Ternary Salt

Abstract

Green chemistry calls for reducing the use of environmentally harmful materials and petroleum resources. Bio-based nylon materials can help address this problem. In this study, a new bio-based nylon 524T ternary salt was discovered and constructed by a green mechanochemical method based on the pharmaceutical cocrystal screening and synthesis strategy. The effects of adding solvents and grinding times on the formation of a ternary salt were systematically studied, and the formation of a nylon 524T ternary salt under solvent-assisted grinding was found to follow a mechanically driven dissolution–recrystallization mechanism. Furthermore, the chemical and physical properties of nylon 524T ternary salt were determined and compared with corresponding nylon 54 binary and 5T binary salts. The results demonstrated that the constructed ternary salt has better thermodynamic property and humidity stability. This contribution offers a new well-performed ternary salt monomer for a potential copolymer PA54/5T with high-temperature resistance, but also a new potential perspective for the molecular segment regulation of the copolymer by direct solid-state polymerization and a green and efficient strategy to construct a copolymer ternary salt monomer.

Discovering crystal forms of the bio-based nylon 5O monomer 1,5-pentanediamine-O-phthalate: insight into the crystal structures, transformations and stability

“…High-quality monomers are essential to the synthesis of excellent performance polymers, and crystallization technology is a convenient method for the efficient preparation and purification of monomers. 24–26 During our research, we found that PDA-OPA exists in four crystal forms in crystallization experiments, one MeOH solvate and three hydrates (named monohydrate, dihydrate, and trihydrate). Meanwhile, we also accidentally obtained two anhydrous forms with non-equimolar ratios, named anhydrate-I and anhydrate-II, and another anhydrous form III, but only single crystals of I and II were obtained.…”

Mechanochemical recrystallization: Forgotten basics and new possibilities

“…-the effects of adding solvents and grinding times on the formation of a ternary salt were systematically studied, and the formation of a nylon 524T ternary salt under solvent-assisted grinding was found to follow a mechanically driven dissolution-recrystallization mechanism [25];…”

Highly Efficient Production of Desired Solid Forms of Drugs with Improved Mechanical Properties via an Organic Solvent-Free Sublimation Process

“…In all, the extensive use of organic solvents in drug production will eventually translate into a huge environmental threat and considerable costs of waste treatment . Therefore, the development of sustainable chemical techniques has become a major trend. , As the principles of Green Chemistry advocate, the search for clean and cheap product processing that is safer and more efficient is an urgent challenge for the pharmaceutical industry. − …”