Green light induces antinociception via visual-somatosensory circuits

Cao, Peng; Zhang, Mingjun; Ni, Ziyun; Song, Xiang-Jie; Yang, Chen-Ling; Mao, Yu; Zhou, Wenjie; Dong, Wanying; Peng, Xiaoqi; Zheng, Chao; Zhang, Zhi; Jin, Yan; Tao, Wenjuan

doi:10.1016/j.celrep.2023.112290

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…Interestingly, another study revealed that a circuit linking the visual cortex and the anterior cingulate cortex circuit plays a pivotal role in mediating the antinociceptive effects of green light (Fig. 3 C) [ 100 ]. Given that the vLGN-related visual circuits are also needed for green light analgesia, it would be interesting to investigate the mechanisms underlying the interaction between vLGN-related visual circuits and the cerebral cortex.…”

Section: Animal Studiesmentioning

confidence: 99%

A Comprehensive Overview of the Neural Mechanisms of Light Therapy

2023

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Light is a powerful environmental factor influencing diverse brain functions. Clinical evidence supports the beneficial effect of light therapy on several diseases, including depression, cognitive dysfunction, chronic pain, and sleep disorders. However, the precise mechanisms underlying the effects of light therapy are still not well understood. In this review, we critically evaluate current clinical evidence showing the beneficial effects of light therapy on diseases. In addition, we introduce the research progress regarding the neural circuit mechanisms underlying the modulatory effects of light on brain functions, including mood, memory, pain perception, sleep, circadian rhythm, brain development, and metabolism.

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Section: Animal Studiesmentioning

confidence: 99%

A Comprehensive Overview of the Neural Mechanisms of Light Therapy

2023

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“… 36 Consistent with the characteristics of melanopsin, most studies have reported the beneficial effects of green/blue light. 37 , 38 For instance, exposure to green light via the visual system resulted in lesser pain in an acute migraine episode compared to the exposure of other wavelengths such as white, blue, amber, and red. 39 And Tang et al 5 unilateral intra-articular injection of complete Freund’s adjuvant in mice to produced mouse model of arthritic pain, then exposed the models to green light.…”

Section: Characteristics Of Light Exerting Analgesic Effects In Cpmentioning

confidence: 99%

“…Artificial inhibition of ACC-projecting V2M Glu neurons abolishes the antinociception induced by green light. 7 This means that the V2M-ACC circuit is a potential candidate mediating green light-induced antinociceptive effects to treat immune pain. These results provide circumstantial evidence explaining how green light exerts analgesic effects in immune-related CP.…”

Section: Targets Associated With Photoanalgesiamentioning

confidence: 99%

“… 41 On the contrary, green light therapy is administered at 4–110 lux. 5 , 6 , 38 , 40 The high tissue penetrance of red and near-infrared lights may induce thermal injury, but no adverse effects have been reported in any clinical or animal studies of visual light therapy. Based on these findings, visual light exposure can be a useful analgesic therapy.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

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Looking for a Beam of Light to Heal Chronic Pain

Xu,

Zhang,

Chen

et al. 2024

JPR

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Chronic pain (CP) is a leading cause of disability and a potential factor that affects biological processes, family relationships, and self-esteem of patients. However, the need for treatment of CP is presently unmet. Current methods of pain management involve the use of drugs, but there are different degrees of concerning side effects. At present, the potential mechanisms underlying CP are not completely clear. As research progresses and novel therapeutic approaches are developed, the shortcomings of current pain treatment methods may be overcome. In this review, we discuss the retinal photoreceptors and brain regions associated with photoanalgesia, as well as the targets involved in photoanalgesia, shedding light on its potential underlying mechanisms. Our aim is to provide a foundation to understand the mechanisms underlying CP and develop light as a novel analgesic treatment has its biological regulation principle for CP. This approach may provide an opportunity to drive the field towards future translational, clinical studies and support pain drug development.

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