Green extraction of flavonoids and phenolic acids from elderberry (Sambucus nigra L.) and rosemary (Rosmarinus officinalis L.) using deep eutectic solvents

Simultaneous extraction of total polyphenols and triterpenes from leaves ofCeltis sinensisby deep eutectic solvent hybrid system combined with response surface methodology

“…Compared with DES1, the HBA of DES9 was still choline chloride, but the HBD was changed from acid to alcohol. Because the extraction capability of a DES is closely related to the intrinsic H bonding, π–π, n–π and polarity of the DES nanostructures, which is conversely affected by the molar ratio, 24,25 a stronger 26 hydrogen bond between DES and solution improves the dissolution of active compounds. With the addition of HBD content, the yields of total polyphenols and triterpenes were reduced.…”

Green Strategies for Recovery of Bioactive Phenolic Compounds from Agro-Industrial Wastes (Pomegranate Peels, Almond Hulls, and Elderberry Pomace) Using Natural Deep Eutectic Solvents

“…Finally, the studies found in the literature involving NADES and elderberries concern only elderberry flowers: Vladimir-Knezěvićet al 14 used NADES based on choline chloride and ethylene glycol/glycerol to recover phenolic compounds from the flowers. They found a range of 1−4 mg of GAE g −1 , according to the amount of water added to their solvents (from 0 to 50%).…”

“…14 In this sense, the so-called natural deep eutectic solvents (NADES) emerged in the past decade as greener cost-effective solvents, with high capacity of effectively extracting bioactive compounds from food wastes. 14,15 Other characteristics, like wide polarity range, nontoxicity, easy preparation, and tailored properties, make NADES a suitable and green alternative for the extraction of phenolics and anthocyanins from pomegranate peels, almond hulls, and elderberry pomace. 16−18 The success in using NADES compared to traditional phenolic extraction solvents, such as ethanol, methanol, and water, has already been reported for several plant matrices: in a recent study, Jurićet al (2021) 19 reported that their NADES based on choline chloride and different hydrogen-bond donors were as or more effective than ethanol for the extraction of flavonoids and cinnamic acids from Mentha piperita, and that the extracts based on these NADES showed better antioxidant and antibacterial activities.…”

Tetrabutylammonium bromide-based hydrophobic deep eutectic solvent for the extraction and separation of dihydromyricetin from vine tea and its inhibitory efficiency against xanthine oxidase

“…DES in the extraction and separation of natural active compounds is still in its initial stage. So far, the natural DES has been applied to the extraction of essential oils, 11 and phenolic, 12 avonoid, 13,14 anthracene, 15 and hop compounds. 16 In the future, there will be increasingly more research on extraction and separation processes with DES, which will be also very meaningful.…”