Green, environment-friendly, analytical tools give insights in pharmaceuticals and cosmetics analysis

Mohamed, Heba M.

doi:10.1016/j.trac.2014.11.010

Cited by 121 publications

(57 citation statements)

References 99 publications

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“…LC techniques usually consume large volumes of high‐purity solvents used as extracting agents, cleaning agents, and mobile phases . Regarding the previous chiral HPLC methods for GUA, we have found that consumption of large amounts of hazardous solvents/run were followed .…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination of guaifenesin enantiomers and ambroxol HCl using 50‐mm chiral column for a negligible environmental impact

2019

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Chiral stationary phases are conveniently used for enantiomeric separation of drugs by liquid chromatography. Consumption of large volumes of hazardous solvents is considered as a common challenge for the sustainability of this technique. To this end, a columnar chromatography has been adopted using 50mm-length stationary phases. The study comprised five Phenomenex Lux cellulose-and amylose-based columns for the separation of guaifenesin (GUA) enantiomers. In addition, an experimental design was used to optimize the gradient profile for the separation of racemic GUA and ambroxol HCl (AMB) binary mixture. The chromatographic method was achieved using Lux Cellulose-1 (50 × 4.6 mm) as a chiral stationary phase and ethanol/water as a mobile phase with linear gradient elution of 20% to 70% ethanol in 6 minutes at a flow rate of 1.0 mL min −1 and UV detection at 270 nm.Linearity ranges were found to be 50 to 1000 μg mL −1 and 15 to 450 μg mL −1 for each GUA enantiomer and AMB, respectively. Environmental, health and safety tool was used to assess and compare greenness of the proposed and reported methods. Short column indeed reduces the environmental impact by decreasing waste by about 60% and utilizing only 1-mL ethanol in the mobile phase. The proposed method is a safer alternative for the simultaneous determination of drugs in their combined pharmaceutical formulation. The method has been validated and compared favorably with a reported one.

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Section: Resultsmentioning

confidence: 99%

Simultaneous determination of guaifenesin enantiomers and ambroxol HCl using 50‐mm chiral column for a negligible environmental impact

2019

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“…Los tipos de productos y procesos que han adoptado los principios de la química verde incluyen medicina, cosméticos [15], polímeros [16], producción de alimentos [17], producción de energía [18], empaques, productos de limpieza del hogar y comercial, industria electrónica [19] y automotriz [20].…”

Section: Química Verdeunclassified

Recent progress in synthesis, properties and potential applications of SiC nanomaterials

Zhou

Yue

et al. 2015

Progress in Materials Science

456

217

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“…Different approaches can be applied for the assessment of greenness of analytical methods (Van Aken, Strekowski, & Patiny 2006). One of these approaches, the method's greenness profile, can be assessed with the analytical eco-Scale, a semi-quantitative, green metric tool (Gałuszka, Migaszewski, & Namiesnik, 2013;Mohamed, 2015). The greenness of analytical methods was measured according to four criteria: the use of persistent, bio-accumulative and toxic chemicals; the use of hazardous chemicals; corrosiveness (pH during the analysis <2 or > 12); and the amount of waste generated (>50 g) (Young & Raynie, 2011).…”

Section: Assessment Of Greenness Profile Of Tlc Method: the Analyticamentioning

confidence: 99%

Chromatographic methods development, validation and degradation characterization of the antithyroid drug Carbimazole

Abdelrahman

2019

Biomedical Chromatography

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The current paper reports the development and validation of stability‐indicating HPLC and HPTLC methods for the separation and quantification of main impurity and degradation product of Carbimazole. The structures of the degradation products formed under stress degradation conditions, including hydrolytic and oxidative, photolytic and thermal conditions, were characterized and confirmed by MS and IR analyses. Based on the characterization data, the obtained degradation product from hydrolytic conditions was found to be methimazole—impurity A of Carbimazole as reported by the British Pharmacopeia and the European Pharmacopeia. A stability‐indicating HPLC method was carried out using a Zorbax Eclipse Plus CN column (150 × 4.6 mm i.d, 5 μm particle size) and a mobile phase composed of acetonitrile–0.05 m KH2PO4 (20: 80, v/v) in isocratic elution, at a flow rate of 1 mL/min. The method was proved to be sensitive for the determination down to 0.5% of Carbimazole impurity A. Additionally, a stability‐indicating chromatographic HPTLC method was achieved using cyclohexane–ethanol (9:1, v/v) as a developing system on HPTLC plates F254 with UV detection at 225 nm. The proposed HPLC and HPTLC methods were successfully applied to Carbimazole® tablets with mean percentage recoveries of 100.12 and 99.73%, respectively.

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Green, environment-friendly, analytical tools give insights in pharmaceuticals and cosmetics analysis

Cited by 121 publications

References 99 publications

Simultaneous determination of guaifenesin enantiomers and ambroxol HCl using 50‐mm chiral column for a negligible environmental impact

Simultaneous determination of guaifenesin enantiomers and ambroxol HCl using 50‐mm chiral column for a negligible environmental impact

Recent progress in synthesis, properties and potential applications of SiC nanomaterials

Chromatographic methods development, validation and degradation characterization of the antithyroid drug Carbimazole

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