Green Electrospining of Hydroxypropyl Cellulose Nanofibres for Drug Delivery Applications

El‐Newehy, Mohamed H.; El‐Naggar, Mehrez E.; Alotaiby, Saleh; El‐Hamshary, Hany; Moydeen, Meera; Al‐Deyab, Salem S.

doi:10.1166/jnn.2018.13852

Cited by 66 publications

(23 citation statements)

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“…By producing a network of randomly aligned polymer fibers, it is possible to obtain membranes with very high porosity and highly interconnected pores, which have been applied to applications ranging from tissue engineering, 12 energy storage, 13 air filtration, 14 and others. 15 − 17 In order to further enhance these properties, it is possible to incorporate nanomaterials into the polymer solutions prior to spinning as has been shown previously. 18 − 20 In this work, graphene oxide (GO) was functionalized with superhydrophobic polyhedral oligomeric silsesquioxane (POSS) molecules, which have a cage-like structure composed of silicon and oxygen atoms and represent the smallest possible silica nanoparticle size.…”

Section: Introductionmentioning

confidence: 99%

POSS-Functionalized Graphene Oxide/PVDF Electrospun Membranes for Complete Arsenic Removal Using Membrane Distillation

Leaper

Cáceres

Luque-Alled

et al. 2021

ACS Appl. Polym. Mater.

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This work demonstrates very high removal rates (below the detection limit of 0.045 ppb) of inorganic arsenic from water using electrospun polyvinylidene difluoride (PVDF) membranes enhanced by the addition of functionalized graphene oxide in membrane distillation. This shows potential for applications in the many parts of the world suffering from arsenic-contaminated groundwater. These membranes were enhanced by the addition of reduced graphene oxide functionalized with superhydrophobic polyhedral oligomeric silsesquioxane molecules (POSS-rGO) into the spinning solutions. The flux of the best-performing rGO-enhanced membrane (containing 2 wt % POSS-rGO) was 21.5% higher than that of the pure PVDF membrane and almost double that of a commercial polytetrafluoroethylene (PTFE) membrane after 24 h of testing, with rejection values exceeding 99.9%. Furthermore, the flux of this membrane was stable over 5 days (∼28 L m –2 h –1 ) of continuous testing and was more stable than those of the PTFE and control membranes when treating a concentrated fouling solution of calcium carbonate and iron(III) sulfate heptahydrate. It also achieved higher permeate quality in these conditions. The Young’s modulus and ultimate tensile strength of the best-performing membrane increased by 38 and 271%, respectively, compared to the pure polymer membrane, while both had similar porosities of ∼91%.

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Section: Introductionmentioning

confidence: 99%

POSS-Functionalized Graphene Oxide/PVDF Electrospun Membranes for Complete Arsenic Removal Using Membrane Distillation

Leaper

Cáceres

Luque-Alled

et al. 2021

ACS Appl. Polym. Mater.

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“…As recently demonstrated through scale-up processes, electrospinning has emerged as a viable tool in the manufacturing of natural nanocomposite fibers [15][16][17][18]. In the electrospinning process, a high electrical field is applied to obtain a jet flow of polymer solution by rapid solvent evaporation, resulting in the formation of microfibers or nanofibers [19,20].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Poly(acrylonitrile-co-Methyl Acrylate)/Lignin Nanofibers: Effects of Lignin Type and Total Polymer Concentration

et al. 2021

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Lignin macromolecules are potential precursor materials for producing electrospun nanofibers for composite applications. However, little is known about the effect of lignin type and blend ratios with synthetic polymers. This study analyzed blends of poly(acrylonitrile-co-methyl acrylate) (PAN-MA) with two types of commercially available lignin, low sulfonate (LSL) and alkali, kraft lignin (AL), in DMF solvent. The electrospinning and polymer blend solution conditions were optimized to produce thermally stable, smooth lignin-based nanofibers with total polymer content of up to 20 wt % in solution and a 50/50 blend weight ratio. Microscopy studies revealed that AL blends possess good solubility, miscibility, and dispersibility compared to LSL blends. Despite the lignin content or type, rheological studies demonstrated that PAN-MA concentration in solution dictated the blend’s viscosity. Smooth electrospun nanofibers were fabricated using AL depending upon the total polymer content and blend ratio. AL’s addition to PAN-MA did not affect the glass transition or degradation temperatures of the nanofibers compared to neat PAN-MA. We confirmed the presence of each lignin type within PAN-MA nanofibers through infrared spectroscopy. PAN-MA/AL nanofibers possessed similar morphological and thermal properties as PAN-MA; thus, these lignin-based nanofibers can replace PAN in future applications, including production of carbon fibers and supercapacitors.

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“…Hydroxypropyl cellulose (HPC) is a non-ionic and hydrophilic cellulose derivate which is used in different applications in biomedical, pharmaceuticals, food additive, etc. In biomedical applications it is used in the field of ophthalmology as a lubricant for artificial eyes [31], in drug delivery, tissue engineering, wound healing, etc. [32].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats

Grădinaru¹,

Barbălată-Mândru²,

Drobotă³

et al. 2020

Nanomaterials

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A series of nanofibrous composite mats based on polyurethane urea siloxane (PUUS), hydroxypropyl cellulose (HPC) and β-cyclodextrin (β-CD) was prepared using electrospinning technique. PUUS was synthesized by two steps solution polymerization procedure from polytetramethylene ether glycol (PTMEG), dimethylol propionic acid (DMPA), 4,4 -diphenylmethane diisocyanate (MDI) and 1,3-bis-(3-aminopropyl) tetramethyldisiloxane (BATD) as chain extender. Then, the composites were prepared by blending PUUS with HPC or βCD in a ratio of 9:1 (w/w), in 15% dimethylformamide (DMF). The PUUS and PUUS based composite solutions were used for preparation of nanofibrous mats. In order to identify the potential applications, different techniques were used to evaluate the chemical structure (Fourier transform infrared-attenuated total reflectance spectroscopy-FTIR-ATR), morphological structure (Scanning electron microscopy-SEM and Atomic force microscopy-AFM), surface properties (contact angle, dynamic vapors sorption-DVS), mechanical characteristics (tensile tests), thermal (differential scanning calorimetry-DSC) and some preliminary tests for biocompatibility and microbial adhesion.

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Green Electrospining of Hydroxypropyl Cellulose Nanofibres for Drug Delivery Applications

Cited by 66 publications

References 0 publications

POSS-Functionalized Graphene Oxide/PVDF Electrospun Membranes for Complete Arsenic Removal Using Membrane Distillation

POSS-Functionalized Graphene Oxide/PVDF Electrospun Membranes for Complete Arsenic Removal Using Membrane Distillation

Fabrication and Characterization of Electrospun Poly(acrylonitrile-co-Methyl Acrylate)/Lignin Nanofibers: Effects of Lignin Type and Total Polymer Concentration

Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats

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