Green Efficient One-Pot Synthesis and Separation of Nitrones in Water Assisted by a Self-Assembled Nanoreactor

Patamia, Vincenzo; Floresta, Giuseppe; Pistarà, Venerando; Rescifina, Antonio

doi:10.3390/ijms23010236

Cited by 5 publications

(2 citation statements)

References 24 publications

(30 reference statements)

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“…In this example, the supramolecular catalyst was prepared in situ by mixing a rhodium complex with the Ga 4 L 6 12− cage host G , which had a relatively larger size with pyrene-walled ligands ( Figure 7a ). The normally used analogous smaller-sized host was assembled with naphthalene-walled ligands, which had been used widely in mediating various reactions, including dehydration reaction [ 65 ], aza-Darzens reaction [ 66 ], and reductive amination [ 67 ], etc. [ 28 ].…”

Section: Reviewmentioning

confidence: 99%

Site-selective reactions mediated by molecular containers

Wang¹,

Yu²

2022

Beilstein J. Org. Chem.

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In this review, we summarize various site-selective reactions mediated by molecular containers. The emphasis is on those reactions that give different product distributions on the potential reactive sites inside the containers than they do outside, free in solution. Specific cases include site-selective cycloaddition and addition of arenes, reduction of epoxides, α,β-unsaturated aldehydes, azides, halides and alkenes, oxidation of remote C–H bonds and alkenes, and substitution reactions involving ring-opening cyclization of epoxides, nucleophilic substitution of allylic chlorides, and hydrolysis reactions. The product selectivity is interpreted as the consequence of the space shape and environment inside the container. The containers include supramolecular structures self-assembled through metal/ligand interactions or hydrogen bonding and open-ended covalent structures such as cyclodextrins and cavitands. Challenges and prospects for the future are also provided.

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Section: Reviewmentioning

confidence: 99%

Site-selective reactions mediated by molecular containers

Wang¹,

Yu²

2022

Beilstein J. Org. Chem.

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“…To date, the number of products produced by nanotechnology or containing nanomaterials is increasing. Current applications include healthcare (drug delivery, regenerative medicine, and diagnostics), environmental protection, electronics, cosmetics, and information technology [ 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Portable Nanocomposite System for Wound Healing in Space

et al. 2023

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It is well known that skin wound healing could be severely impaired in space. In particular, the skin is the tissue at risk of injury, especially during human-crewed space missions. Here, we propose a hybrid system based on the biocompatible poly 2-hydroxyethyl methacrylate (pHEMA) to actively support a nanocontainer filled with the drug. Specifically, during the cryo-polymerization of HEMA, halloysite nanotubes (HNTs) embedded with thymol (Thy) were added as a component. Thy is a natural pharmaceutical ingredient used to confer wound healing properties to the material, whereas HNTs were used to entrap the Thy into the lumen to ensure a sustained release of the drug. The as-obtained material was characterized by chemical–physical methods, and tests were performed to assess its ability for a prolonged drug release. The results showed that the adopted synthetic procedure allows the formation of a super absorbent system with good swelling ability that can contain up to 5.5 mg of Thy in about 90 mg of dried sponge. Releasing tests demonstrated the excellent material’s ability to perform a slow controlled delivery of 62% of charged Thy within a week. As humans venture deeper into space, with more extended missions, limited medical capabilities, and a higher risk of skin wounds, the proposed device would be a versatile miniaturized device for skin repair in space.

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γ‐Cyclodextrins as Supramolecular Reactors for the Three‐component Aza‐Darzens Reaction in Water

Patamia,

Saccullo,

Zagni

et al. 2024

Chemistry A European J

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In recent decades, many efforts have been devoted to studying reactions catalyzed in nanoconfined spaces. The most impressive aspect of catalysis in nanoconfined spaces is that the reactivity of the molecules can be smartly driven to disobey classical behavior. A green and efficient three‐component aza‐Darzens (TCAD) reaction using a catalytic amount of g‐cyclodextrins (CDs) in water has been developed to synthesize N‐phenylaziridines. CDs effectively performed this reaction in an environmentally friendly setting, achieving good yields. The same reaction was then performed using polymeric g‐CD such as a g‐cyclodextrin polymer crosslinked (GCDPC) with epichlorohydrin, a sponge‐like macroporous g‐cyclodextrin‐based cryogel (GCDC), and a g‐cyclodextrin‐based hydrogel (GCDH). The homogeneous and heterogeneous catalyst recovery was then studied, and it was proved to be easily recycled several times without relevant activity loss. Water, as a unique and eco‐friendly reaction medium, has been utilized for the first time, to the best of our knowledge, in this reaction. The inclusion of the reagents in CDs has been studied and rationalized by NMR spectroscopy experiments and molecular modeling calculations. The credit of the presented protocol includes good yields and catalyst reusability and precludes the use of organic solvents.

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Green Efficient One-Pot Synthesis and Separation of Nitrones in Water Assisted by a Self-Assembled Nanoreactor

Cited by 5 publications

References 24 publications

Site-selective reactions mediated by molecular containers

Site-selective reactions mediated by molecular containers

Portable Nanocomposite System for Wound Healing in Space

γ‐Cyclodextrins as Supramolecular Reactors for the Three‐component Aza‐Darzens Reaction in Water

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