Green does not always mean go: A sulfated galactan from Codium isthmocladum green seaweed reduces melanoma metastasis through direct regulation of malignancy features

Bellan, D. L.; Biscaia, Stellee Marcela Petris; Rossi, Gustavo Rodrigues; Gonçalves, Jenifer Pendiuk; Oliveira, Carolina Camargo de; Simas, Fernanda Fogagnoli; Sabry, Diego Araújo; Rocha, Hugo Alexandre Oliveira; Franco, Célia Regina Cavichiolo; Chammas, Roger; Gillies, Robert J.; Trindade, Edvaldo da Silva

doi:10.1016/j.carbpol.2020.116869

Cited by 17 publications

(7 citation statements)

References 54 publications

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“…Other polysaccharides with antitumor activity have been described in the literature. Examples include (i) a sulfated homogalactan, which was able to reduce the growth of solid tumors and metastasis, without inducing side effects in mice [ 45 ] (ii) a sulfated heterorhamnan, which decreased metastatic capacities, such as migration and invasion of B16-F10 cells [ 46 ]; (iii) a 3-O-methylated heterogalactan, which modulated immunological functions [ 47 ]. All these processes interfere with cellular interactions within the tumor microenvironment (TME) and modify the dynamics of the metastatic process.…”

Section: Resultsmentioning

confidence: 99%

MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine

Biscaia

Pires

Lívero

et al. 2022

IJMS

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Melanoma is a highly metastatic and rapidly progressing cancer, a leading cause of mortality among skin cancers. The melanoma microenvironment, formed from the activity of malignant cells on the extracellular matrix and the recruitment of immune cells, plays an active role in the development of drug resistance and tumor recurrence, which are clinical challenges in cancer treatment. These tumoral metabolic processes are affected by proteins, including Galectin-3 (Gal-3), which is extensively involved in cancer development. Previously, we characterized a partially methylated mannogalactan (MG-Pe) with antimelanoma activities. In vivo models of melanoma were used to observe MG-Pe effects in survival, spontaneous, and experimental metastases and in tissue oxidative stress. Analytical assays for the molecular interaction of MG-Pe and Gal-3 were performed using a quartz crystal microbalance, atomic force microscopy, and contact angle tensiometer. MG-Pe exhibits an additive effect when administered together with the chemotherapeutic agent dacarbazine, leading to increased survival of treated mice, metastases reduction, and the modulation of oxidative stress. MG-Pe binds to galectin-3. Furthermore, MG-Pe antitumor effects were substantially reduced in Gal-3/KO mice. Our results showed that the novel Gal-3 ligand, MG-Pe, has both antitumor and antimetastatic effects, alone or in combination with chemotherapy.

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Section: Resultsmentioning

confidence: 99%

MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine

Biscaia

Pires

Lívero

et al. 2022

IJMS

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“…In addition, sulfated polysaccharide is a polyanion linear macromolecular compound containing sulfuric acid group, which shows a wide range of biological activities [ 32 ]. Among them, antitumor is one of the attractive biological activities of sulfated polysaccharides, and the activity intensity is affected by the monosaccharide composition and number, the type of glycosidic bongs, molecular weight and the number and position of sulfate group and so on [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

A Sulfated Polysaccharide from Red Algae (Gelidium crinale) to Suppress Cells Metastasis and MMP-9 Expression of HT1080 Cells

Zheng

Pei

et al. 2022

Foods

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Sulfated polysaccharides from red algae have a variety of biological activities, especially antitumor activities. Matrix metalloproteinase-9 (MMP-9) is a proteolytic metalloenzyme that degrades the central part of the extracellular matrix (ECM) and promotes tumor metastasis. In this research, we have investigated the influence and mechanism of GNP (sulfated polysaccharide from Gelidium crinale) on tumor metastasis and MMP-9 expression of human fibrosarcoma (HT1080) cells. The results inflected that the concentration of GNP below 100 μg/mL has no toxicity to HT1080 cells, but showed excellent activity in inhibiting cells migration and invasion. In addition, GNP effectively inhibits the mRNA of MMP-9 and reduces its expression and activity by regulating nuclear factor-kappa B (NF-κB), mitogen-activated protein kinases (MAPK) and mTOR/PI3K/Akt signaling pathways. GNP has great potential as MMP-9 inhibitor and could be developed as a functional food or drug to prevent tumor metastasis.

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“…A sulfated homogalactan from C. isthmocladum showed antitumoral activity by reducing the growth and metastasis of solid tumors without any negative drawbacks. (Bellan et al 2020). El-Masry et al (1995) also found that C. sinensis showed antitumoral activity.…”

Section: Antitumoral Activitymentioning

confidence: 94%

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

2022

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The genus Codium is one of the most important genera of marine green macroalgae. Its distribution is widespread worldwide and it has a high degree of diversity in species and characteristics. This genus plays an important ecological role in marine ecosystems as it is a primary producer. However, some species in the genus Codium are invasive species and may disturb the functioning of the ecosystem. Economically, Codium has promising potential as a source of diverse nutritional and pharmacological compounds. Codium is edible, has a high nutrient value, and is rich in bioactive compounds. Hence, some species of Codium have been consumed as food and used as herbal medicines in some Asian countries. In recent decades, studies of the bioactivity and pharmacological properties of the genus Codium have attracted the attention of scientists. This review aims to identify gaps in studies analyzing Codium that have been conducted in the past three decades by assessing published research articles on its bioactivity and pharmacological properties. Compounds obtained from Codium have demonstrated significant biological activities, such as immunostimulatory, anticoagulant, anticancer, anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal, antitumor, anti-angiogenic, osteoprotective, and anti-obesity activities. This review provides information that can be used as a future guideline for sustainably utilizing the genus Codium.

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Green does not always mean go: A sulfated galactan from Codium isthmocladum green seaweed reduces melanoma metastasis through direct regulation of malignancy features

Cited by 17 publications

References 54 publications

MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine

MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine

A Sulfated Polysaccharide from Red Algae (Gelidium crinale) to Suppress Cells Metastasis and MMP-9 Expression of HT1080 Cells

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

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