Green design “bioinspired disassembly-reassembly strategy” applied for improved tumor-targeted anticancer drug delivery

Wang, Ruoning; Gu, Xiaochen; Zhou, Jianping; Shen, Lingjia; Yin, Lifang; Hua, Peiying; Ding, Yang

doi:10.1016/j.jconrel.2016.05.055

Cited by 36 publications

(35 citation statements)

References 45 publications

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“…35 In comparison to native HDLs, the slightly larger HMNs were still appropriate substrates for the binding and recognition by HDL receptors on the basis of earlier studies. 32,48,49 In addition, the different ζ-potentials of HMNs might reflect the exposed NLS-Dox on the surface of nanoparticles, which was used to evaluate roughly the DMPG-coating efficiency of NLS-Dox and anti-miR21 complexes. According to the results (Figure 3B), the ζ-potential of HMNs gradually decreased when the amount of DMPG was increased, and the negatively charged surface of optimized HMNs indicated the absolute shielding of cationic NLS-Dox/anti-miR21 complexes.…”

mentioning

confidence: 99%

Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells

Rui¹,

Qu²,

Gao³

et al. 2016

IJN

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confidence: 99%

Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells

Rui¹,

Qu²,

Gao³

et al. 2016

IJN

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“…Materials : The human plasma sample (precipitate IV) was donated by Tonrol Bio‐Pharmaceutical Co., Ltd. (Hefei, China). Endogenous apoA–I and lipids were isolated and purified from precipitate IV utilizing an organic solvent/isoelectric precipitation method previously described with some modifications . iRGD peptide (CRGDKGPDC) was obtained from GL Bio‐Chem Co, Ltd (Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, these formulations have limitations in clinical applications, such as importing immune disorders and batch variation of synthetic lipoproteins . In our previous studies, a novel green “disassembly–reassembly strategy” approach has been proposed for restoring HDLs with whole endogenous components . Instead of reconstructing HDLs with genetically engineered apolipoproteins and commercial lipids, homogeneously isolated apoA–I and dehydrated human lipids were reassembled according to their original ratio in endogenous HDLs, which are expected to recover the native structure and function, thereby minimizing any unwanted properties.…”

Section: Introductionmentioning

confidence: 99%

Deep Tumor Penetrating Bioparticulates Inspired Burst Intracellular Drug Release for Precision Chemo‐Phototherapy

Wang

Han

Sun

et al. 2018

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The relevance of personalized medicine has inspired research for individually concerted diagnosis and therapy. Numerous efforts are devoted to designing drug particulates with capabilities of tumor penetrating and subcellular trafficking to concurrently discharge theranostics in response to multistimulations. In this study, a bioinspired particulate, formulated with whole components of native high-density lipoproteins (HDLs) and decorated with the tumor-penetrating peptide iRGD, is proposed to promote tumor penetration of HDLs (pHDLs) together with payloads. Specifically, paclitaxel (PTX), and the NIR fluorescent probe indocyanine green (ICG) are integrated into pHDLs (pHDL/PTX-ICG) for synergetic chemo-phototherapy. Inspired by lipoproteins, pHDLs are not only restored from naturally occurring materials but also possessed artificially endowed functions, leading to an enhanced cellular uptake, higher accumulation, and deep penetration into tumors without causing appreciable adverse effects, compared to reconstituted HDLs or lipid-based nanoparticles. After intravenous administration, pHDL/PTX-ICG performs a burst of intracellular drug release and imaging-guided precision chemo-phototherapy upon NIR irradiation that completely eradicates xenograft tumors. Neither recurrence nor significant toxicity is observed due to maneuvered regional photodynamic and photothermal therapy. Taken together, pHDL/PTX-ICG is proven to be a promising platform to achieve deep tumor penetration and imaging-guided chemo-phototherapy.

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“…6A). 40 Specifically, the components of native lipoproteins in human plasma were isolated and purified using an organic solvent/isoelectric precipitation method. Together with the payload, the lipid-containing organic phase (in ethanol) was added dropwise into an apolipoprotein-containing aqueous phase at a weight ratio identical to that of native lipoproteins, leading to the formation of drug-loaded LMPs.…”

Section: Reconstituted Ldl For Contrast Enhancement and Therapymentioning

confidence: 99%

Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications

Zhu

Xia

2017

Chem. Soc. Rev.

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Low-density lipoprotein (LDL), one of the four major groups of lipoproteins for lipid transport in vivo, is emerging as an attractive carrier for the targeted delivery of theranostic agents. In contrast to the synthetic systems, LDL particles are intrinsically biocompatible and biodegradable, together with reduced immunogenicity and natural capabilities to target cancerous cells and to escape from the recognition and elimination by the reticuloendothelial system. Enticed by these attributes, a number of strategies have been developed for reconstituting LDL particles, including conjugation to the apolipoprotein, insertion into the phospholipid layer, and loading into the core. Here we present a tutorial review on the development of reconstituted LDL (rLDL) particles for theranostic applications. We start with a brief introduction to LDL and LDL receptor, as well as the advantages of using rLDL particles as a natural and versatile platform for the targeted delivery of theranostic agents. After a discussion of commonly used strategies for the reconstitution of LDL, we highlight the applications of rLDL particles in the staging of disease progression, treatment of lesioned tissues, and delivery of photosensitizers for photodynamic cancer therapy. We finish this review with a perspective on the remaining challenges and future directions.

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Green design “bioinspired disassembly-reassembly strategy” applied for improved tumor-targeted anticancer drug delivery

Cited by 36 publications

References 45 publications

Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells

Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells

Deep Tumor Penetrating Bioparticulates Inspired Burst Intracellular Drug Release for Precision Chemo‐Phototherapy

Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications

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