Green coffee extract attenuates Parkinson’s-related behaviors in animal models

Molska, Graziella Rigueira; Paula-Freire, Lyvia Izaura Gomes; Sakalem, Marna Eliana; Köhn, Daniele Oliveira; Negri, Giuseppina; Carlini, E. A.; Mendes, Fúlvio Rieli

doi:10.1590/0001-3765202120210481

Cited by 4 publications

(3 citation statements)

References 66 publications

(48 reference statements)

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“…Several adenosinergic antagonists, including caffeine, have shown effect at this animal model [35][36]. In a previous study, we demonstrated that a green coffee extract, rich in chlorogenic acid, was able to inhibit the haloperidol-induced catalepsy [17].…”

Section: Discussionmentioning

confidence: 79%

“…Cataleptic status was evaluated after 45 minutes of the haloperidol administration. Each mouse was placed with both front paws over bars suspended 5 cm from the surface and the time to remove the paws was counted, up to 10 consecutive trials or up to 10 minutes [17]. The catalepsy score was obtained dividing catalepsy total time (seconds) by the number of times the mice left the bar.…”

Section: Haloperidol-induced Catalepsymentioning

confidence: 99%

“…Rotational behavior was accessed on the 14 th day after surgery with the administration of apomorphine (0.1 mg/kg, sc) and on the 15 th day, after administration of methamphetamine (2.5 mg/kg, ip). The number of complete (360°) contralateral and ipsilateral rotations was counted by a blind observer for one hour after the administration of each drug [17]. The treatment with coffee on the test days was made after the behavioral observation and the animals were euthanized approximately 24h after the last treatment.…”

Section: Rotational Behaviormentioning

confidence: 99%

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Anticholinesterase and Pro-dopaminergic Effects of Instant Coffee

Köhn¹,

Molska²,

Paula-Freire³

et al. 2022

Preprint

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Epidemiologic studies suggest an inverse correlation between coffee consumption and the occurrence of neurodegenerative diseases, but the role of caffeine and roasting degree are still matter of debate. The objective of this work was to evaluate the effects of caffeinated (light, medium, and dark roast) and decaffeinated instant coffee samples in acetylcholinesterase inhibition and antioxidant assays, as well as in animal models of Parkinson’s disease. Caffeinated coffees inhibited the acetylcholinesterase in much smaller concentrations than decaffeinated coffee. All coffee samples showed antioxidant capacity without relation with the caffeine content. Dopaminergic-like activity in the haloperidol-induced catalepsy test was observed with caffeinated coffee, but not in the decaffeinated sample. The medium roast coffee reduced the number of rotations of rats after methamphetamine administration on the 6-hydroxydopamine unilateral lesion of the medial forebrain bundle. However, the coffee treatment did not avoid the loss of dopaminergic neurons on substantia nigra pars compact and only the smallest dose of coffee was able to avoid the decrease of dopamine levels in the lesioned side of the striatum. Altogether, these results suggest that coffee exerts moderate pro-cholinergic and pro-dopaminergic effects and caffeine seems to be the main responsible for these effects.

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Section: Discussionmentioning

confidence: 79%

Section: Haloperidol-induced Catalepsymentioning

confidence: 99%

Section: Rotational Behaviormentioning

confidence: 99%

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Anticholinesterase and Pro-dopaminergic Effects of Instant Coffee

Köhn¹,

Molska²,

Paula-Freire³

et al. 2022

Preprint

Self Cite

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Anticholinesterase and Anticalaleptic Effects of Instant Coffee

Köhn,

Molska,

de Paula-Freire

et al. 2023

Journal of Medicinal Food

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Pharmacological Perspective of Green Coffee Beans and their Metabolites: A Review

Tripathi

Mishra²

2023

CNF

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Coffee is the most extensively consumed drink in the world. However, in the last few years, unroasted coffee seeds, popularly known as green coffee beans (GCB), attracted people due to its health properties. This review covers pharmacological efficacy, mechanism of action and bioactive components of green coffee beans. It contains a unique set of polyphenolic compounds, methylxanthines and diterpenes which are responsible for the astringency, flavour, smell and taste as well as for its health benefits. Chlorogenic acid, a polyphenolic compound, is the major bioactive compound in coffee beans which contributes most to the medicinal activities present in it. The finding reveals the effectiveness of green coffee beans in all parameters of metabolic syndrome by regulating adipokines. It prevents doxorubicin induced cardiomyocyte cell death and also has antimutagenic activity on the HeLa cell line and PA-1 cell line. Neuroprotective effect of GCB in degenerative disease was achieved by reducing neuroinflammatory markers TNF-α (tumor necrosis factor-α) and IL-1β (interleukin-1β). Along with these properties, GCB has shown some potential antimicrobial, hepatoprotective, cardioprotective and sunscreen effects, as it contains a high sun protection factor. The findings from this study conclude that green coffee beans have shown bizarrely several health benefits, but a large number of trials and intervention are required to establish its medicinal values.

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Green coffee extract attenuates Parkinson’s-related behaviors in animal models

Cited by 4 publications

References 66 publications

Anticholinesterase and Pro-dopaminergic Effects of Instant Coffee

Anticholinesterase and Pro-dopaminergic Effects of Instant Coffee

Anticholinesterase and Anticalaleptic Effects of Instant Coffee

Pharmacological Perspective of Green Coffee Beans and their Metabolites: A Review

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