Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice

Abstract

GCBE has a potential anti-obesity effect with lowering body fat accumulation by regulating adipogenesis and lipid metabolism-related genes and proteins in WAT and liver.

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

“…In the present study, GCE improved metabolic profile of MS through adiponectin increase [20,21]. This study demonstrated a significantly higher adiponectin level in GCE 100 and GCE 200 compared to that of MS group.…”

“…This study revealed that adiponectin level of GCE 100 was higher than that of GCE 200 although it was not achieve any statistical significance. In contrast, Choi et al suggested that higher GCE dose resulted in higher adiponectin level [21]. The differences of substances composition …”

“…The extract used in our study was not purified, some caffeine and other polyphenols might contain in our extract on the other hand, Choi et al used GCE contained 50% of caffeoylquinic acid (CQA) [21]. The chronic effect of higher GCE dose administration on homocysteine level might explain lower adiponectin level in higher GCE dose.…”

Green and roasted coffee extracts as antioxidants in βTC3 cells with induced oxidative stress and lipid accumulation inhibitors in 3T3L1 cells, and their bioactivity in rats fed high fat diet

“…Antioxidant activity of CHAs decrease the risk of several oxidative stress-related diseases, including atherosclerosis, some kinds of cancer and Alzheimer's disease [9][10][11]. Consumption of coffee containing CHAs and other bioactive compounds also helps to fight against obesity and limits the effects of type 2 diabetes [12,13]. The antioxidant activity of particular CHAs is similar, although diesters containing two caffeic acid molecules and hence four hydroxyl groups may have stronger antioxidant activity then monoesters.…”

Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles

“…These plants include Adenophora triphylla [9], Cudrania tricuspidata [10], Crinum asiaticum [11], Hibiscus sabdariffa [12], green coffee bean [13], and Tripterygium wilfordii [14]. Several active anti-obesity ingredients present in plants have also been identified, such as saponins from Glycyrrhiza uralensis [15] and Astragalus propinquus [16], polysaccharides from Lycium barbarum [17,18] and Schisandra chinensis [18], and polyphenols from Crataegus pinnatifida Bunge [19].…”