Green Catalytic Process for Click Synthesis Promoted by Copper Oxide Nanocomposite Supported on Graphene Oxide

Abstract

Thec atalytic activity of graphene oxide supported copper oxide (CuO-GO)h as been investigated in Clicks ynthesis of 1,2,3-triazole derivatives under green reactionc onditions.I nthe context of green approach, water is useda ss olvent under ligand free and aerobic conditions at room temperature,w ith lowc atalyst loading (0.2mol %) while ensuring the recovery and reusability of the catalyst. Thec atalyst affords excellent selectivity in formation of the desired productsi ng ood to excellent yields. Further, the work-up procedure adopted here is clean ands imple,while recycling the organic solvents that one usedf or work-up procedure.I ti sp roposed that the functional groups present on the GO surface are effective for preventing the aggregation of the catalytically active copper oxide species during the reaction. Moreover, the excellent performance of CuO-GO nanocomposite is ascribed to the excellent dispersity of the catalyst in water, hydrophilic nature of the GO for the accumulation of organic substrates in water and the "Breslowe ffect."

Functionalized Graphene Obtained via Thiol-Ene Click Reactions as an Efficient Electrochemical Sensor

“…Moreover, click chemistry has many successful cases of the modification of graphene derivatives and carbon materials under mild conditions with a vast range of the functional groups. For example, the classic click reaction of the copper catalyzed azide‐alkyne cycloaddition (CuAAC) has been applied in the chemical functionalization of graphene and its derivatives (graphene oxide or reduced graphane oxide) . However, the toxicity of Cu(I) ions limit the scope application of the CuAAC despite of its fast and effective click reaction.…”

Magnetic Isinglass a Nano‐Bio Support for Copper Immobilization: Cu–IG@Fe3O4 a Heterogeneous Catalyst for Triazoles Synthesis

“…Finally, sodium azide act as both an azidonation reagent and a reducing agent producing in situ click‐ catalytic active Cu I species without additional reducing agent (Scheme ) . A considerable number of protocols have been reported in the litrature on the Huisgen click reaction without using any additional reducing agents –,…”

Heterogeneous azide–alkyne cycloaddition in the presence of a copper catalyst supported on an ionic liquid polymer/silica hybrid material

“…Besides some rare examples of special copper complexes, e.g. Cu(I)(tris(2‐dioctadecylaminoethyl)amine)Br that shows unusual solubility‐based thermomorphic properties in polar solvents that allows recovery of the active form by simple filtration, the most prevailing solution for effective catalyst recycling is the immobilisation of the active species on a solid support, such as charcoal, graphene oxide, alumina, clays or organic/inorganic hybrid materials . Among them, SiO 2 with grafted imidazolium cations was proved to be an excellent support, resulting in a stable catalyst that could be used several times under solvent‐free conditions.…”