Green aqueous synthesis and antimicrobial evaluation of 3,5-disubstituted 1,2,4-triazoles

Iodine Catalyzed Oxidative Coupling of Diaminoazines and Amines for the Synthesis of 3,5-Disubstituted-1,2,4-Triazoles

“…Owing to their broad spectrum of functions, several synthetic methods have been developed for the generation of 3,5-disubstituted 1 H -1,2,4-triazoles Scheme A includes a few representative metal-free methods for the synthesis of 3,5-disubstituted-1,2,4-trizaoles (more examples are provided in Scheme S1, SI).…”

“…There are numerous available methods for the synthesis of 1,2,4-triazoles (Schemes A, S1), but most of the methods require multistep synthetic procedures as well as the use of nonreadily available starting materials. The metal-catalyzed reactions (Scheme S1), although having wide applications, suffer some specific limitations, especially in the pharmaceutical industry, where removing traces of the metallic species from the active pharmaceutical ingredient (API) turns out to be a big challenge .…”