Green approaches to comprehensive two-dimensional liquid chromatography (LC × LC)

Aly, Alshymaa A.; Górecki, Tadeusz; Omar, Mahmoud A.

doi:10.1016/j.jcoa.2022.100046

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…The authors revealed that the effective peak distribution and peak capacity obtained with PC as an organic modifier were comparable to those obtained using ACN and MeOH. Despite the significantly reduced runtime (32 min for methods with PC vs 52 min for methods with ACN and MeOH), an improvement in separation selectivity was achieved [48]. Тhis research confirmed the role of propylene carbonate as an effective substitute for acetonitrile, providing greater separation power even in 2D LC.…”

Section: Propylene Carbonatementioning

confidence: 69%

“…The most recent research that demonstrates the applicability of PC as a replacement for ACN has focused on the separation of a mixture of 39 pharmaceutical compounds in two-dimensional liquid chromatography (2D LC) [48]. The authors revealed that the effective peak distribution and peak capacity obtained with PC as an organic modifier were comparable to those obtained using ACN and MeOH.…”

Section: Propylene Carbonatementioning

confidence: 99%

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Green Strategies toward Eco-Friendly HPLC Methods in Pharma Analysis

Nakov¹,

Acevska²,

Brezovska³

et al. 2023

High Performance Liquid Chromatography - Recent Advances and Applications

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The global need for changing the processes in order to meet the green analytical chemistry (GAC) criteria is a great challenge for the pharmaceutical industry. High-performance liquid chromatography (HPLC), as one of the most frequently used techniques in various stages in the pharmaceutical industry, generates huge amounts of organic toxic waste. Therefore, the implementation of the GAC principles in pharma analysis is highly required. Although the number of published papers concerning green chromatography approaches is constantly increasing, the use of eco-friendly HPLC methods in the pharma industry has not been widely implemented. The reasons for this mainly include the need for adaptation of the conventional HPLC instruments, lack of time, lack of experience, or uncertainty of the analysts regarding fulfillment of the method criteria. In this chapter, an overview of green strategies that can be easily applied to conventional instruments for liquid chromatography (LC) in developing eco-friendly HPLC methods in pharma analysis is given. The aim is to emphasize that the green method development in pharma analysis can be easily accomplished and to encourage the analytical community in the pharmaceutical industry not only to develop but also to transfer the already established conventional HPLC methods into green ones.

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Section: Propylene Carbonatementioning

confidence: 69%

Section: Propylene Carbonatementioning

confidence: 99%

Green Strategies toward Eco-Friendly HPLC Methods in Pharma Analysis

Nakov¹,

Acevska²,

Brezovska³

et al. 2023

High Performance Liquid Chromatography - Recent Advances and Applications

View full text Add to dashboard Cite

show abstract

“…PC can be used to separate 39 medicinal substances mixture using two-dimensional liquid chromatography (2D LC). Despite having a substantially shorter duration, the study indicated that PC's effective peak distribution and peak capacity as an organic modifier were equivalent to those of ACN and MeOH (52 minutes for ACN and MeOH against 32 minutes for PC) [24]. PC Propylene carbonate is an effective substitute for acetonitrile, providing greater separation power in 2D LC, opening the possibility for wider applications.…”

Section: Green Solvents As a Mobile Phasementioning

confidence: 96%

Green Analytical Chemistry to Eco-Friendly HPLC Techniques in Pharmaceutical Analysis: A Review

Abd-Elhafeez,

Arafa,

Amro

et al. 2024

Egyptian Journal of Veterinary Sciences

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REEN Chemistry (GC) is designing chemical processes and products to decrease the use of harmful materials, based on 12 theories established in 1998. The pharmaceutical industry faces a significant problem due to the worldwide requirement to comply with Green Analytical Chemistry (GAC) requirements. High-pressure liquid chromatography (HPLC) is a widely used process in the medicine industry, but it produces massive quantities of organic hazardous waste. Analytical techniques must be optimized for precision, sensitivity, repeatability, effortlessness, cost effectiveness, versatility, and speed. Though, other factors such as analysts' security and ecological effects are rarely considered. Although there are more publications about green chromatography techniques, there has not been much adoption of eco-friendly HPLC techniques in the pharmaceutical business. The major causes of this are the need for adapting the standard HPLC apparatus, a lack of time, knowledge, or analysts' confusion over the fulfilment of the method requirements. An overview of green approaches for liquid chromatography (LC) that may be quickly applied to traditional instruments was provided to create eco-friendly HPLC procedures for pharmaceutical analysis.

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Green comprehensive two-dimensional liquid chromatography (LC × LC) for the analysis of phenolic compounds in grape juices and wine

Aly

Górecki

2022

Anal Bioanal Chem

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Green approaches to comprehensive two-dimensional liquid chromatography (LC × LC)

Cited by 9 publications

References 29 publications

Green Strategies toward Eco-Friendly HPLC Methods in Pharma Analysis

Green Strategies toward Eco-Friendly HPLC Methods in Pharma Analysis

Green Analytical Chemistry to Eco-Friendly HPLC Techniques in Pharmaceutical Analysis: A Review

Green comprehensive two-dimensional liquid chromatography (LC × LC) for the analysis of phenolic compounds in grape juices and wine

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